U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    sqv-5 Chondroitin sulfate synthase sqv-5;Hexosyltransferase [ Caenorhabditis elegans ]

    Gene ID: 172851, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    sqv-5
    Official Full Name
    Chondroitin sulfate synthase sqv-5;Hexosyltransferase
    Primary source
    WormBase:WBGene00005023
    Locus tag
    CELE_T24D1.1
    See related
    AllianceGenome:WB:WBGene00005023
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables enzyme binding activity. Involved in several processes, including egg-laying behavior; positive regulation of vulval development; and vulval development. Located in cytoplasm. Is expressed in oocyte; uterus; and vulva. Human ortholog(s) of this gene implicated in temtamy preaxial brachydactyly syndrome. Orthologous to human CHSY1 (chondroitin sulfate synthase 1) and CHSY3 (chondroitin sulfate synthase 3). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See sqv-5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (9947804..9953391)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene RING-type domain-containing protein Neighboring gene RING-type domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Caenorhabditis elegans early embryogenesis and vulval morphogenesis require chondroitin biosynthesis. Hwang HY, et al. Nature, 2003 May 22. PMID 12761549
    2. Nematode chondroitin polymerizing factor showing cell-/organ-specific expression is indispensable for chondroitin synthesis and embryonic cell division. Izumikawa T, et al. J Biol Chem, 2004 Dec 17. PMID 15485872
    3. Endogenous chondroitin extends the lifespan and healthspan in C. elegans. Shibata Y, et al. Sci Rep, 2024 Feb 27. PMID 38413743, Free PMC Article
    4. Cytokinesis: GAGs form the walls that separate our parts. White J, et al. Curr Biol, 2003 Sep 16. PMID 13678612
    5. Sweet control of cell migration, cytokinesis and organogenesis. Podbilewicz B. Nat Cell Biol, 2004 Jan. PMID 14704673

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetylgalactosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chondroitin sulfate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in morphogenesis of an epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Chondroitin sulfate synthase sqv-5;Hexosyltransferase
    NP_001021639.3
    • Confirmed by transcript evidence
    NP_001021640.2
    • Confirmed by transcript evidence
    NP_001300439.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9947804..9953391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026469.8 → NP_001021640.2  Chondroitin sulfate synthase sqv-5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021640.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KXH9
      Conserved Domains (2) summary
      pfam05679
      Location:234 → 726
      CHGN; Chondroitin N-acetylgalactosaminyltransferase
      cl21608
      Location:82 → 274
      Galactosyl_T; Galactosyltransferase

    2. NM_001313510.4 → NP_001300439.1  Hexosyltransferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EGA1, O02330, Q7YTF6, Q7Z1Z1
      UniProtKB/TrEMBL
      A0A0K3ATP9, Q7KXH9
      Conserved Domains (2) summary
      pfam05679
      Location:236 → 728
      CHGN; Chondroitin N-acetylgalactosaminyltransferase
      cl21608
      Location:84 → 276
      Galactosyl_T; Galactosyltransferase

    3. NM_001026468.8 → NP_001021639.3  Chondroitin sulfate synthase sqv-5 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KXH9
      Conserved Domains (2) summary
      pfam05679
      Location:226 → 718
      CHGN; Chondroitin N-acetylgalactosaminyltransferase
      cl21608
      Location:74 → 266
      Galactosyl_T; Galactosyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z1Z1.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools