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    hda-6 Histone deacetylase 6;UBP-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177316, updated on 4-Jan-2025

    Summary

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    Official Symbol
    hda-6
    Official Full Name
    Histone deacetylase 6;UBP-type domain-containing protein
    Primary source
    WormBase:WBGene00018319
    Locus tag
    CELE_F41H10.6
    See related
    AllianceGenome:WB:WBGene00018319
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable histone deacetylase activity. Predicted to be involved in epigenetic regulation of gene expression. Predicted to be located in nucleus. Predicted to be part of histone deacetylase complex. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia. Orthologous to human HDAC6 (histone deacetylase 6). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See hda-6 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    11
    Sequence:
    Chromosome: IV; NC_003282.8 (5356543..5364306, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene WH2 domain-containing protein Neighboring gene ncRNA Neighboring gene TLC domain-containing protein Neighboring gene ncRNA Neighboring gene GRIP domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Microtubule regulators act in the nervous system to modulate fat metabolism and longevity through DAF-16 in C. elegans. Xu A, et al. Aging Cell, 2019 Apr. PMID 30638295, Free PMC Article
    2. The nphp-2 and arl-13 genetic modules interact to regulate ciliogenesis and ciliary microtubule patterning in C. elegans. Warburton-Pitt SR, et al. PLoS Genet, 2014 Dec. PMID 25501555, Free PMC Article
    3. Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity. Bates EA, et al. J Neurosci, 2006 Mar 8. PMID 16525063, Free PMC Article
    4. Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism. Yu R, et al. Nat Commun, 2021 Mar 31. PMID 33790287, Free PMC Article
    5. H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage. Wang S, et al. Nat Struct Mol Biol, 2020 Dec. PMID 33046905

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables histone deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein lysine deacetylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epigenetic regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of histone deacetylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Histone deacetylase 6;UBP-type domain-containing protein
    NP_001122780.1
    • Confirmed by transcript evidence
    NP_001255270.1
    • Confirmed by transcript evidence
    NP_500787.1
    • Confirmed by transcript evidence
    NP_500788.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      5356543..5364306 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129308.4 → NP_001122780.1  UBP-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A7LPD8
      Conserved Domains (2) summary
      pfam02148
      Location:877 → 939
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl17011
      Location:440 → 795
      Arginase_HDAC; Arginase-like and histone-like hydrolases

    2. NM_068386.5 → NP_500787.1  Histone deacetylase 6 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20296, Q9BI90, Q9BI91
      Conserved Domains (2) summary
      pfam02148
      Location:875 → 937
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl17011
      Location:438 → 793
      Arginase_HDAC; Arginase-like and histone-like hydrolases

    3. NM_001268341.3 → NP_001255270.1  UBP-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G8JYB7
      Conserved Domains (1) summary
      pfam02148
      Location:58 → 120
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    4. NM_068387.5 → NP_500788.1  Histone deacetylase 6 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20296
      Conserved Domains (1) summary
      cl17011
      Location:438 → 793
      Arginase_HDAC; Arginase-like and histone-like hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20296.2

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