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    des-2 Acetylcholine receptor DES-2-like protein;Acetylcholine receptor subunit alpha-type des-2 [ Caenorhabditis elegans ]

    Gene ID: 179574, updated on 9-Dec-2024

    Summary

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    Official Symbol
    des-2
    Official Full Name
    Acetylcholine receptor DES-2-like protein;Acetylcholine receptor subunit alpha-type des-2
    Primary source
    WormBase:WBGene00000955
    Locus tag
    CELE_T26H10.1
    See related
    AllianceGenome:WB:WBGene00000955
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in chemical synaptic transmission; monoatomic ion transmembrane transport; and regulation of membrane potential. Located in plasma membrane. Is expressed in head neurons; interneuron; and pm1. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See des-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    10
    Sequence:
    Chromosome: V; NC_003283.11 (11415272..11421705, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Ground-like domain-containing protein Neighboring gene Acetylcholine receptor subunit alpha-type deg-3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene FRG domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The fusogen EFF-1 controls sculpting of mechanosensory dendrites. Oren-Suissa M, et al. Science, 2010 Jun 4. PMID 20448153, Free PMC Article
    2. Caenorhabditis elegans nicotinic acetylcholine receptors are required for nociception. Cohen E, et al. Mol Cell Neurosci, 2014 Mar. PMID 24518198, Free PMC Article
    3. RIC-3 affects properties and quantity of nicotinic acetylcholine receptors via a mechanism that does not require the coiled-coil domains. Ben-Ami HC, et al. J Biol Chem, 2005 Jul 29. PMID 15932871
    4. GFP is a selective non-linear optical sensor of electrophysiological processes in Caenorhabditis elegans. Khatchatouriants A, et al. Biophys J, 2000 Nov. PMID 11053114, Free PMC Article
    5. Spaceflight affects neuronal morphology and alters transcellular degradation of neuronal debris in adult Caenorhabditis elegans. Laranjeiro R, et al. iScience, 2021 Feb 19. PMID 33659873, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The conserved residues in the second RIC-3 transmembrane domain are needed for its interactions with DEG-3,DES-2 and ACR-16.
      Title: Receptor and subunit specific interactions of RIC-3 with nicotinic acetylcholine receptors.
    2. subunit-specific interactions of RIC-3 with nAChR subunits DEG-3/DES-2, mediated by the transmembrane domains, are sufficient for the effects of RIC-3 on nAChR quantity and quality
      Title: RIC-3 affects properties and quantity of nicotinic acetylcholine receptors via a mechanism that does not require the coiled-coil domains.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transmembrane transporter complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Acetylcholine receptor DES-2-like protein;Acetylcholine receptor subunit alpha-type des-2
    NP_001379140.1
    • Confirmed by transcript evidence
    NP_001380111.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11415272..11421705 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392615.1 → NP_001379140.1  Acetylcholine receptor subunit alpha-type des-2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76554
      Conserved Domains (3) summary
      cd19051
      Location:239 → 332
      LGIC_TM_cation; transmembrane domain of Cys-loop neurotransmitter-gated ion channels, includes 5HT3, nAChR, and ZAC
      pfam02931
      Location:28 → 222
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:245 → 531
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    2. NM_001392616.1 → NP_001380111.1  Acetylcholine receptor DES-2-like protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G2Y4
      Conserved Domains (2) summary
      cd19051
      Location:239 → 332
      LGIC_TM_cation; transmembrane domain of Cys-loop neurotransmitter-gated ion channels, includes 5HT3, nAChR, and ZAC
      pfam02931
      Location:28 → 222
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76554.1

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