gsa-1 Guanine nucleotide-binding protein G(s) subunit alpha [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gsa-1
Official Full Name: Guanine nucleotide-binding protein G(s) subunit alpha
Primary source: WormBase:WBGene00001745
Locus tag: CELE_R06A10.2
See related: AllianceGenome:WB:WBGene00001745
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in several processes, including negative regulation of protein kinase C signaling; nematode pharyngeal pumping; and positive regulation of oocyte maturation. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in several structures, including excretory cell; intestine; neurons; non-striated muscle; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including ACTH-independent macronodular adrenal hyperplasia 1; dystonia 25; pituitary adenoma 3; progressive osseous heteroplasia; and pseudohypoparathyroidism (multiple). Orthologous to several human genes including GNAL (G protein subunit alpha L). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gsa-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 8

Sequence:: Chromosome: I; NC_003279.8 (1068484..1074343)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Galpha/GSA-1 works upstream of PKA/KIN-1 to regulate calcium signaling and contractility in the Caenorhabditis elegans spermatheca.
Title: Gα/GSA-1 works upstream of PKA/KIN-1 to regulate calcium signaling and contractility in the Caenorhabditis elegans spermatheca.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R06A10.2 (e-PCR)
- UniSTS:320334

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta/gamma-subunit complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta/gamma-subunit complex binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables guanyl nucleotide binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating dopamine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to stimulus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein kinase C signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte growth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of oocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of defecation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of establishment of cell polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sensory perception of chemical stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in serotonin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Guanine nucleotide-binding protein G(s) subunit alpha

NP_001367988.1

Confirmed by transcript evidence

NP_001368357.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

1068484..1074343

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001380927.2 → NP_001367988.1 Guanine nucleotide-binding protein G(s) subunit alpha [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G5EF72, Q7KPV0

Conserved Domains (1) summary

cd00066
Location:40 → 372

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
NM_001380932.1 → NP_001368357.1 Guanine nucleotide-binding protein G(s) subunit alpha [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

V6CL61

Conserved Domains (1) summary

cd00066
Location:7 → 279

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)