daf-11 Receptor-type guanylate cyclase daf-11;guanylate cyclase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: daf-11
Official Full Name: Receptor-type guanylate cyclase daf-11;guanylate cyclase
Primary source: WormBase:WBGene00000907
Locus tag: CELE_B0240.3
See related: AllianceGenome:WB:WBGene00000907
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable guanylate cyclase activity and peptide receptor activity. Involved in several processes, including cellular response to cGMP; determination of adult lifespan; and olfactory learning. Located in dendrite; neuronal cell body; and non-motile cilium. Is expressed in amphid neurons. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See daf-11 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 17

Sequence:: Chromosome: V; NC_003283.11 (11718102..11726071, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Trimethylamine modulates dauer formation, neurodegeneration, and lifespan through tyra-3/daf-11 signaling in Caenorhabditis elegans.
Title: Trimethylamine modulates dauer formation, neurodegeneration, and lifespan through tyra-3/daf-11 signaling in Caenorhabditis elegans.
The receptor-bound guanylyl cyclase DAF-11 is the mediator of hydrogen peroxide-induced Cgmp increase in Caenorhabditis elegans.
Title: The Receptor-Bound Guanylyl Cyclase DAF-11 Is the Mediator of Hydrogen Peroxide-Induced cGMP Increase in Caenorhabditis elegans [corrected].

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0240.3 (e-PCR)
- UniSTS:308835

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables guanylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activity	IEA Inferred from Electronic Annotation more info
enables guanylate cyclase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cGMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cGMP biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cellular response to cGMP	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cilium assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cyclic nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in dauer larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dauer larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of dauer larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in receptor guanylyl cyclase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor guanylyl cyclase signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor guanylyl cyclase signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dauer larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of dauer larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to pheromone	IEA Inferred from Electronic Annotation more info
involved_in response to temperature stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of smell	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Receptor-type guanylate cyclase daf-11;guanylate cyclase

NP_001300011.1

Confirmed by transcript evidence

NP_505960.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

11718102..11726071 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073559.8 → NP_505960.3 Receptor-type guanylate cyclase daf-11 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_505960.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8I4N4

Conserved Domains (5) summary

smart00044
Location:729 → 922

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:756 → 943

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam07701
Location:714 → 750

HNOBA; Heme NO binding associated

cl10011
Location:33 → 295

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

cl21453
Location:447 → 695

PKc_like; Protein Kinases, catalytic domain
NM_001313082.3 → NP_001300011.1 guanylate cyclase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AUK6

Conserved Domains (4) summary

smart00044
Location:511 → 704

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:538 → 725

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam07701
Location:496 → 532

HNOBA; Heme NO binding associated

cl21453
Location:229 → 477

PKc_like; Protein Kinases, catalytic domain