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    ret-1 Reticulon-like protein [ Caenorhabditis elegans ]

    Gene ID: 179981, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ret-1
    Official Full Name
    Reticulon-like protein
    Primary source
    WormBase:WBGene00004336
    Locus tag
    CELE_W06A7.3
    See related
    AllianceGenome:WB:WBGene00004336
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Located in endomembrane system. Is expressed in several structures, including gonad and nervous system. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 12. Orthologous to several human genes including RTN3 (reticulon 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ret-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    13
    Sequence:
    Chromosome: V; NC_003283.11 (14829177..14847413, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Transmembrane protein 144 Neighboring gene Nematode Specific Peptide family, group A Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RTN2 deficiency results in an autosomal recessive distal motor neuropathy with lower limb spasticity. Maroofian R, et al. Brain, 2024 Jul 5. PMID 38527963, Free PMC Article
    2. Developmental Wiring of Specific Neurons Is Regulated by RET-1/Nogo-A in Caenorhabditis elegans. Torpe N, et al. Genetics, 2017 Jan. PMID 27821431, Free PMC Article
    3. Cytoplasmic streaming drifts the polarity cue and enables posteriorization of the Caenorhabditis elegans zygote at the side opposite of sperm entry. Kimura K, et al. Mol Biol Cell, 2020 Jul 21. PMID 32459552, Free PMC Article
    4. Caenorhabditis elegans reticulon interacts with RME-1 during embryogenesis. Iwahashi J, et al. Biochem Biophys Res Commun, 2002 May 3. PMID 12054525
    5. A role for Rab5 in structuring the endoplasmic reticulum. Audhya A, et al. J Cell Biol, 2007 Jul 2. PMID 17591921, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. C. elegans RTN, which has low homology to human RTNs, also interacted with human BACE1 and inhibited Abeta secretion.
      Title: The two-hydrophobic domain tertiary structure of reticulon proteins is critical for modulation of beta-secretase BACE1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endomembrane system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Reticulon-like protein
    NP_001024190.1
    • Confirmed by transcript evidence
    NP_001123026.1
    • Confirmed by transcript evidence
    NP_001129910.1
    • Confirmed by transcript evidence
    NP_001379166.1
    • Confirmed by transcript evidence
    NP_001379411.1
    • Confirmed by transcript evidence
    NP_506656.2
    • Confirmed by transcript evidence
    NP_506658.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      14829177..14847413 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129554.5 → NP_001123026.1  Reticulon-like protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001123026.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDI2
      Conserved Domains (2) summary
      pfam02453
      Location:3104 → 3272
      Reticulon; Reticulon
      cl23777
      Location:2835 → 2918
      PRK01558; V-type ATP synthase subunit E; Provisional

    2. NM_074255.8 → NP_506656.2  Reticulon-like protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506656.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECZ2
      Conserved Domains (2) summary
      pfam02453
      Location:3104 → 3268
      Reticulon; Reticulon
      cl23777
      Location:2835 → 2918
      PRK01558; V-type ATP synthase subunit E; Provisional

    3. NM_001136438.3 → NP_001129910.1  Reticulon-like protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129910.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5U8N2
      Conserved Domains (2) summary
      pfam02453
      Location:299 → 463
      Reticulon; Reticulon
      cl23777
      Location:30 → 113
      PRK01558; V-type ATP synthase subunit E; Provisional

    4. NM_001392662.1 → NP_001379166.1  Reticulon-like protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23187
      Conserved Domains (1) summary
      pfam02453
      Location:57 → 221
      Reticulon

    5. NM_001392661.1 → NP_001379411.1  Reticulon-like protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JLB1
      Conserved Domains (2) summary
      cl23777
      Location:106 → 189
      PRK01005; V-type ATP synthase subunit E; Provisional
      pfam02453
      Location:375 → 539
      Reticulon

    6. NM_074257.6 → NP_506658.1  Reticulon-like protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506658.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23188
      Conserved Domains (1) summary
      pfam02453
      Location:29 → 191
      Reticulon; Reticulon

    7. NM_001029019.6 → NP_001024190.1  Reticulon-like protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024190.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JLB0
      Conserved Domains (1) summary
      pfam02453
      Location:9 → 173
      Reticulon; Reticulon
    Nucleotide Protein
    Heading Accession and Version

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