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    noca-1 Non-centrosomal microtubule array protein 1 [ Caenorhabditis elegans ]

    Gene ID: 3565610, updated on 9-Dec-2024

    Summary

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    Official Symbol
    noca-1
    Official Full Name
    Non-centrosomal microtubule array protein 1
    Primary source
    WormBase:WBGene00011647
    Locus tag
    CELE_T09E8.1
    See related
    AllianceGenome:WB:WBGene00011647
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in cytoplasmic microtubule organization; germ cell development; and nematode larval development. Located in microtubule. Is expressed in hyp7 syncytium and intestinal cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See noca-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    21
    Sequence:
    Chromosome: V; NC_003283.11 (13152919..13176115)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Cubilin Neighboring gene Dynein Heavy Chain Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene High Incidence of Males (increased X chromosome loss) Neighboring gene Protein cornichon homolog 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Non-centrosomal epidermal microtubules act in parallel to LET-502/ROCK to promote C. elegans elongation. Quintin S, et al. Development, 2016 Jan 1. PMID 26586219, Free PMC Article
    2. NOCA-1 functions with γ-tubulin and in parallel to Patronin to assemble non-centrosomal microtubule arrays in C. elegans. Wang S, et al. Elife, 2015 Sep 15. PMID 26371552, Free PMC Article
    3. PTRN-1 (CAMSAP) and NOCA-2 (NINEIN) are required for microtubule polarity in Caenorhabditis elegans dendrites. He L, et al. PLoS Biol, 2022 Nov. PMID 36395330, Free PMC Article
    4. Epidermal PAR-6 and PKC-3 are essential for larval development of C. elegans and organize non-centrosomal microtubules. Castiglioni VG, et al. Elife, 2020 Dec 10. PMID 33300872, Free PMC Article
    5. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in hemidesmosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Non-centrosomal microtubule array protein 1
    NP_001041165.1
    • Partially confirmed by transcript evidence
    NP_001303706.1
    • Confirmed by transcript evidence
    NP_001370898.1
    • Partially confirmed by transcript evidence
    NP_506274.1
    • Partially confirmed by transcript evidence
    NP_506275.2
    • Partially confirmed by transcript evidence
    NP_506276.2
    • Partially confirmed by transcript evidence
    NP_872199.2
    • Partially confirmed by transcript evidence
    NP_872200.1
    • Partially confirmed by transcript evidence
    NP_872201.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13152919..13176115
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316777.4 → NP_001303706.1  Non-centrosomal microtubule array protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEK3
      Conserved Domains (1) summary
      COG1196
      Location:514 → 728
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. NM_073873.3 → NP_506274.1  Non-centrosomal microtubule array protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506274.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEK3

    3. NM_001383436.1 → NP_001370898.1  Non-centrosomal microtubule array protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      COG1196
      Location:187 → 401
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    4. NM_182399.8 → NP_872199.2  Non-centrosomal microtubule array protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_872199.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0M3UPV7, G5EBN2, G5EBP7, G5EC74, G5EE58, G5EEK3, N1NSE8, Q8I4G1, Q9XVL5
      Conserved Domains (2) summary
      pfam15619
      Location:567 → 727
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
      cl03075
      Location:612 → 698
      GrpE; nucleotide exchange factor GrpE

    5. NM_001047700.5 → NP_001041165.1  Non-centrosomal microtubule array protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041165.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEK3
      Conserved Domains (1) summary
      pfam01496
      Location:338 → 477
      V_ATPase_I; V-type ATPase 116kDa subunit family

    6. NM_073874.7 → NP_506275.2  Non-centrosomal microtubule array protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506275.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEK3
      Conserved Domains (1) summary
      pfam01496
      Location:336 → 475
      V_ATPase_I; V-type ATPase 116kDa subunit family

    7. NM_073875.5 → NP_506276.2  Non-centrosomal microtubule array protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506276.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEK3
      Conserved Domains (1) summary
      pfam01496
      Location:394 → 533
      V_ATPase_I; V-type ATPase 116kDa subunit family

    8. NM_182401.5 → NP_872201.2  Non-centrosomal microtubule array protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_872201.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEK3
      Conserved Domains (1) summary
      pfam01496
      Location:194 → 333
      V_ATPase_I; V-type ATPase 116kDa subunit family

    9. NM_182400.7 → NP_872200.1  Non-centrosomal microtubule array protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_872200.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEK3
      Conserved Domains (1) summary
      pfam01496
      Location:194 → 333
      V_ATPase_I; V-type ATPase 116kDa subunit family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EEK3.1

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