ceh-36 Homeobox protein ceh-36 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ceh-36
Official Full Name: Homeobox protein ceh-36
Primary source: WormBase:WBGene00000457
Locus tag: CELE_C37E2.4
See related: AllianceGenome:WB:WBGene00000457
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in neuron fate specification; positive regulation of transcription by RNA polymerase II; and sensory perception of chemical stimulus. Located in nucleus. Is expressed in ABaraappa; ABaraappaa; amphid neurons; and head neurons. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 5. Orthologous to human NOBOX (NOBOX oogenesis homeobox); ARGFX (arginine-fifty homeobox); and DPRX (divergent-paired related homeobox). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ceh-36 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 7

Sequence:: Chromosome: X; NC_003284.9 (14183221..14186566, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This work provides the first example of genetic redundancy between the related yet evolutionarily distant OTX and PITX families of bicoid class homeodomain factors and demonstrates the power of quantitative developmental phenotyping in C. elegans
Title: The Bicoid class homeodomain factors ceh-36/OTX and unc-30/PITX cooperate in C. elegans embryonic progenitor cells to regulate robust development.
MLS-2 specifies the identity of the AWC sensory neuron type via regulation of the ceh-36 Otx gene.
Title: The HMX/NKX homeodomain protein MLS-2 specifies the identity of the AWC sensory neuron type via regulation of the ceh-36 Otx gene in C. elegans.
These results suggest that ceh-36 is required for functions, and not for development, of ASE chemosensory neurons in Caenorhabditis elegans.
Title: The C. elegans ceh-36 gene encodes a putative homemodomain transcription factor involved in chemosensory functions of ASE and AWC neurons.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C37E2.4 (e-PCR)
- UniSTS:321976

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in neuron fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of chemical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Homeobox protein ceh-36

NP_510365.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

14183221..14186566 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077964.5 → NP_510365.1 Homeobox protein ceh-36 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510365.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q93352

Conserved Domains (1) summary

pfam00046
Location:59 → 115

Homeobox; Homeobox domain