grl-7 Ground-like domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: grl-7
Official Full Name: Ground-like domain-containing protein
Primary source: WormBase:WBGene00001716
Locus tag: CELE_T02E9.2
See related: AllianceGenome:WB:WBGene00001716
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Located in apical plasma membrane. Is expressed in hypodermis; intestine; and ventral cord blast cell. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See grl-7 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 6

Sequence:: Chromosome: V; NC_003283.11 (11344828..11347012, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Caenorhabditis elegans PTR/PTCHD PTR-18 promotes the clearance of extracellular hedgehog-related protein via endocytosis.
Title: Caenorhabditis elegans PTR/PTCHD PTR-18 promotes the clearance of extracellular hedgehog-related protein via endocytosis.
Provide evidence that two hedgehog-related (hh-r) genes, grl-5 and grl-7, are targets of miR-235 that promote reactivation of quiescent neuroblasts. These grl genes possess an miR-235 binding site on 3'UTRs of their transcripts, and are upregulated in starved mir-235 mutant larvae.
Title: Hedgehog-related genes regulate reactivation of quiescent neural progenitors in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T02E9.2 (e-PCR)
- UniSTS:305880

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Ground-like domain-containing protein

NP_001024093.1

Confirmed by transcript evidence

NP_001024094.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

11344828..11347012 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001028923.7 → NP_001024094.1 Ground-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024094.1

Status: REVIEWED

UniProtKB/TrEMBL

Q52GX6

Conserved Domains (2) summary

PRK07764
Location:45 → 163

PRK07764; DNA polymerase III subunits gamma and tau; Validated

pfam04155
Location:260 → 330

Ground-like; Ground-like domain
NM_001028922.4 → NP_001024093.1 Ground-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024093.1

Status: REVIEWED

UniProtKB/TrEMBL

O18015

Conserved Domains (2) summary

PRK07764
Location:45 → 160

PRK07764; DNA polymerase III subunits gamma and tau; Validated

pfam04155
Location:279 → 349

Ground-like; Ground-like domain