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    mps-2 MiRP K channel accessory Subunit [ Caenorhabditis elegans ]

    Gene ID: 173419, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mps-2
    Official Full Name
    MiRP K channel accessory Subunit
    Primary source
    WormBase:WBGene00019282
    Locus tag
    CELE_K01A2.8
    See related
    AllianceGenome:WB:WBGene00019282
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables potassium channel regulator activity. Involved in long-term memory; regulation of chemotaxis; and regulation of potassium ion transport. Predicted to be located in membrane. Is expressed in several structures, including coelomocyte; enteric muscle; intestine; lateral ganglion; and rectal muscle. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mps-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (309479..312157, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene AB hydrolase-1 domain-containing protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene DUF2231 domain-containing protein;Transmembrane protein Neighboring gene pseudo Neighboring gene MiRP K channel accessory Subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dual Role of an mps-2/KCNE-Dependent Pathway in Long-Term Memory and Age-Dependent Memory Decline. Fenyves BG, et al. Curr Biol, 2021 Feb 8. PMID 33259792
    2. An evolutionarily conserved family of accessory subunits of K+ channels. Cai SQ, et al. Cell Biochem Biophys, 2006. PMID 16943626
    3. A family of K+ channel ancillary subunits regulate taste sensitivity in Caenorhabditis elegans. Park KH, et al. J Biol Chem, 2005 Jun 10. PMID 15799965
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables potassium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of potassium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of potassium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MiRP K channel accessory Subunit
    NP_001033335.1
    • Product from WormBase gene class mps;
      Confirmed by transcript evidence
    NP_001379579.1
    • Product from WormBase gene class mps;
      Confirmed by transcript evidence
    NP_001379580.1
    • Product from WormBase gene class mps;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      309479..312157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392992.1 → NP_001379580.1  MiRP K channel accessory Subunit [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86S20

    2. NM_001392991.1 → NP_001379579.1  MiRP K channel accessory Subunit [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q56VR8, Q9TZ55

    3. NM_001038246.6 → NP_001033335.1  MiRP K channel accessory Subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001033335.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q56VR8, Q56VR9
    Nucleotide Protein
    Heading Accession and Version

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