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    dnj-8 DnaJ homolog subfamily C member 16;Thioredoxin domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174093, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dnj-8
    Official Full Name
    DnaJ homolog subfamily C member 16;Thioredoxin domain-containing protein
    Primary source
    WormBase:WBGene00001026
    Locus tag
    CELE_C56C10.13
    See related
    AllianceGenome:WB:WBGene00001026
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in autophagy. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human DNAJC16 (DnaJ heat shock protein family (Hsp40) member C16). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dnj-8 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (6594382..6598080, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Charged multivesicular body protein 4b Neighboring gene 45 kDa calcium-binding protein Neighboring gene TPR_REGION domain-containing protein Neighboring gene Ectopic P granules protein 5 Neighboring gene Vacuolar protein sorting-associated protein 33B Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ERdj8 governs the size of autophagosomes during the formation process. Yamamoto YH, et al. J Cell Biol, 2020 Aug 3. PMID 32492081, Free PMC Article
    2. A Differentiation Transcription Factor Establishes Muscle-Specific Proteostasis in Caenorhabditis elegans. Bar-Lavan Y, et al. PLoS Genet, 2016 Dec. PMID 28036392, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DnaJ homolog subfamily C member 16;Thioredoxin domain-containing protein
    NP_001040753.1
    • Confirmed by transcript evidence
    NP_001040754.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6594382..6598080 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047288.5 → NP_001040753.1  DnaJ homolog subfamily C member 16 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040753.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95QQ1
      Conserved Domains (2) summary
      cd02963
      Location:118 → 229
      TRX_DnaJ; TRX domain, DnaJ domain containing protein family; composed of uncharacterized proteins of about 500-800 amino acids, containing an N-terminal DnaJ domain followed by one redox active TRX domain. DnaJ is a member of the 40 kDa heat-shock protein (Hsp40) ...
      TIGR02349
      Location:22 → 86
      DnaJ_bact; chaperone protein DnaJ

    2. NM_001047289.6 → NP_001040754.1  Thioredoxin domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040754.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B2MZA7
      Conserved Domains (2) summary
      COG0484
      Location:2 → 23
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      cd02963
      Location:55 → 166
      TRX_DnaJ; TRX domain, DnaJ domain containing protein family; composed of uncharacterized proteins of about 500-800 amino acids, containing an N-terminal DnaJ domain followed by one redox active TRX domain. DnaJ is a member of the 40 kDa heat-shock protein (Hsp40) ...
    Nucleotide Protein
    Heading Accession and Version

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