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    dhs-28 SCP2 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180950, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dhs-28
    Official Full Name
    SCP2 domain-containing protein
    Primary source
    WormBase:WBGene00000991
    Locus tag
    CELE_M03A8.1
    See related
    AllianceGenome:WB:WBGene00000991
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 3-hydroxyacyl-CoA dehydrogenase activity and enoyl-CoA hydratase activity. Involved in several processes, including ascaroside biosynthetic process; dauer entry; and pheromone biosynthetic process. Located in peroxisome. Is expressed in hypodermis and intestine. Used to study obesity. Human ortholog(s) of this gene implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome. Orthologous to human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dhs-28 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    6
    Sequence:
    Chromosome: X; NC_003284.9 (6818438..6820080)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Autophagy-related protein 2 Neighboring gene GEX Interacting protein Neighboring gene ZM domain-containing protein Neighboring gene Secreted protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biosynthesis of the Caenorhabditis elegans dauer pheromone. Butcher RA, et al. Proc Natl Acad Sci U S A, 2009 Feb 10. PMID 19174521, Free PMC Article
    2. Caenorhabditis elegans utilizes dauer pheromone biosynthesis to dispose of toxic peroxisomal fatty acids for cellular homoeostasis. Joo HJ, et al. Biochem J, 2009 Jul 29. PMID 19496754
    3. Toxicity of sodium fluoride to Caenorhabditis elegans. Li Q, et al. Biomed Environ Sci, 2012 Apr. PMID 22998830
    4. Comparative metabolomics reveals biogenesis of ascarosides, a modular library of small-molecule signals in C. elegans. von Reuss SH, et al. J Am Chem Soc, 2012 Jan 25. PMID 22239548, Free PMC Article
    5. Peroxisome protein transportation affects metabolism of branched-chain fatty acids that critically impact growth and development of C. elegans. Wang R, et al. PLoS One, 2013. PMID 24086720, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 3-hydroxyacyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enoyl-CoA hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ascaroside biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dauer entry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pheromone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of developmental growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to pheromone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in very long-chain fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SCP2 domain-containing protein
    NP_509146.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      6818438..6820080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076745.8 → NP_509146.1  SCP2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509146.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21481
      Conserved Domains (2) summary
      cd05353
      Location:3 → 252
      hydroxyacyl-CoA-like_DH_SDR_c-like; (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs
      pfam02036
      Location:325 → 429
      SCP2; SCP-2 sterol transfer family
    Nucleotide Protein
    Heading Accession and Version

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