TMEM41A transmembrane protein 41A [Homo sapiens (human)] - Gene

Summary

Official Symbol: TMEM41Aprovided by HGNC
Official Full Name: transmembrane protein 41Aprovided by HGNC
Primary source: HGNC:HGNC:30544
See related: Ensembl:ENSG00000163900 AllianceGenome:HGNC:30544
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: 2900010K02Rik
Summary: Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in small intestine (RPKM 11.1), duodenum (RPKM 11.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q27.2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (185489601..185499035, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (188305359..188314797, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (185207389..185216823, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TMEM41A overexpression correlates with poor prognosis and immune alterations in patients with endometrial carcinoma.
Title: TMEM41A overexpression correlates with poor prognosis and immune alterations in patients with endometrial carcinoma.
The present study demonstrated a reduction in TMEM41A expression levels in a pair of GC cell lines, and revealed that high TMEM41A expression levels may promote GC-associated metastasis, which may be mediated by the downregulation of E-cadherin expression.
Title: Expression of transmembrane protein 41A is associated with metastasis via the modulation of E‑cadherin in radically resected gastric cancer.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2279 (e-PCR)
- UniSTS:473907

RH93790 (e-PCR)
- UniSTS:89702

WI-21163 (e-PCR)
- UniSTS:52596

RH80449 (e-PCR)
- UniSTS:92283

MGC15397__7672 (e-PCR)
- UniSTS:466319

D11S3114 (e-PCR)
- UniSTS:152207

RH46339 (e-PCR)
- UniSTS:26316

SHGC-77628 (e-PCR)
- UniSTS:66253

STS-W72274 (e-PCR)
- UniSTS:64767

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane protein 41A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.