TRIM71 tripartite motif containing 71 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRIM71provided by HGNC
Official Full Name: tripartite motif containing 71provided by HGNC
Primary source: HGNC:HGNC:32669
See related: Ensembl:ENSG00000206557 MIM:618570; AllianceGenome:HGNC:32669
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HYC4; LIN41; HYDCC1; LIN-41
Summary: The protein encoded by this gene is an E3 ubiquitin-protein ligase that binds with miRNAs and maintains the growth and upkeep of embryonic stem cells. This gene also is involved in the G1-S phase transition of the cell cycle. [provided by RefSeq, Dec 2015]
Expression: Biased expression in testis (RPKM 4.2), kidney (RPKM 0.7) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 3p22.3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (32817997..32897824)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (32816172..32895937)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (32859489..32939316)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.
Title: HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.
TRIM7 Restricts Coxsackievirus and Norovirus Infection by Detecting the C-Terminal Glutamine Generated by 3C Protease Processing.
Title: TRIM7 Restricts Coxsackievirus and Norovirus Infection by Detecting the C-Terminal Glutamine Generated by 3C Protease Processing.
TRIM71 binds to IMP1 and is capable of positive and negative regulation of target RNAs.
Title: TRIM71 binds to IMP1 and is capable of positive and negative regulation of target RNAs.
Ubiquitin ligase TRIM71 suppresses ovarian tumorigenesis by degrading mutant p53.
Title: Ubiquitin ligase TRIM71 suppresses ovarian tumorigenesis by degrading mutant p53.
TRIM71-mediated target recognition and repression mechanisms uncovers a role for this stem cell-specific factor and oncogene in non-canonical Nonsense-mediated Decay (NMD), revealing the existence of a novel mRNA surveillance mechanism which has been termed here the TRIM71/NMD axis.
Title: The mRNA repressor TRIM71 cooperates with Nonsense-Mediated Decay factors to destabilize the mRNA of CDKN1A/p21.
TRIM71 mutations implicated in etiogenesis of human congenital hydrocephalus impair target silencing
Title: The RNA hairpin binder TRIM71 modulates alternative splicing by repressing MBNL1.
TRIM71 acts through post-transcriptional repression of Lin28B and subsequent modulation of let-7-HMGA2 signaling during tumorigenesis to potentially function as a tumor suppressor.
Title: TRIM71 suppresses tumorigenesis via modulation of Lin28B-let-7-HMGA2 signaling.
Studies indicate most-studied TRIpartite Motif (TRIM)-NHL proteins TRIM2, TRIM3, TRIM32 and TRIM71, and their mutations have been linked to diseases.
Title: TRIM-NHL proteins in development and disease.
Consistent with the let-7 microRNA stimulatory role of TRIM71 via Lin28B polyubiquitination.
Title: The ubiquitin ligase human TRIM71 regulates let-7 microRNA biogenesis via modulation of Lin28B protein.
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Title: Exploration of deleterious single nucleotide polymorphisms in the components of human P bodies: an in silico approach.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Hydrocephalus, congenital communicating, 1 MedGen: C5231454 OMIM: 618667 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D3S4127 (e-PCR)
- UniSTS:39467

G63581 (e-PCR)
- UniSTS:140692

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables miRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables miRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation repressor activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA destabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in G1/S transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in fibroblast growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in miRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in miRNA-mediated gene silencing by inhibition of translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in neural tube closure	IEA Inferred from Electronic Annotation more info
involved_in neural tube development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of miRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect post-transcriptional regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein autoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neural precursor cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in stem cell proliferation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
located_in P-body	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRIM71

Names: RING-type E3 ubiquitin transferase TRIM71; abnormal cell LINeage LIN-41; homolog of C. elegans Lin-41; protein lin-41 homolog; tripartite motif containing 71, E3 ubiquitin protein ligase; tripartite motif-containing protein 71

NP_001034200.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039111.3 → NP_001034200.1 E3 ubiquitin-protein ligase TRIM71

See identical proteins and their annotated locations for NP_001034200.1

Status: REVIEWED

Source sequence(s)

AC139452, AW196612, DQ232881

Consensus CDS

CCDS43060.1

UniProtKB/Swiss-Prot

Q2Q1W2

Related

ENSP00000373272.3, ENST00000383763.6

Conserved Domains (7) summary

smart00502
Location:314 → 444

BBC; B-Box C-terminal domain

cd14954
Location:584 → 868

NHL_TRIM71_like; NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins

sd00039
Location:704 → 740

7WD40; WD40 repeat [structural motif]

cd16589
Location:8 → 97

RING-HC_TRIM71_C-VII; RING finger, HC subclass, found in tripartite motif-containing protein 71 (TRIM71) and similar proteins

cd19796
Location:277 → 322

Bbox2_TRIM71_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 71 (TRIM71) and similar proteins

cd19812
Location:198 → 240

Bbox1_TRIM71_C-VII; B-box-type 1 zinc finger found in tripartite motif-containing protein 71 (TRIM71) and similar proteins

pfam00630
Location:482 → 577

Filamin; Filamin/ABP280 repeat