These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

1. NM_001291006.2 → NP_001277935.1  leucine-rich repeat-containing protein 74B

   See identical proteins and their annotated locations for NP_001277935.1

   Status: VALIDATED

   Description

   Transcript Variant: This variant (1) represents the shortest transcript and encodes the protein.

   Source sequence(s)

   AC002472

   Consensus CDS

   CCDS77654.1

   UniProtKB/Swiss-Prot

   Q6ZQY2

   Related

   ENSP00000394078.2, ENST00000442047.3

   Conserved Domains (2) summary

   sd00033
   Location:109 → 136

   LRR_RI; leucine-rich repeat [structural motif]

   cl42388
   Location:57 → 357

   PPP1R42; protein phosphatase 1 regulatory subunit 42

RNA

1. NR_027006.2 RNA Sequence

   Status: VALIDATED

   Description

   Transcript Variant: This variant (2) contains multiple differences in the internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most [supported/expected] translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

   Source sequence(s)

   AC002472, AK128646, BC028231, BC036220

2. NR_110991.2 RNA Sequence

   Status: VALIDATED

   Description

   Transcript Variant: This variant (3) contains multiple differences in the internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most [supported/expected] translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

   Source sequence(s)

   AC002472

   Related

   ENST00000497328.5

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference GRCh38.p14 Primary Assembly

Genomic

1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

   Range

   21045946..21064168

   Download

   GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

1. XM_011530175.2 → XP_011528477.1  leucine-rich repeat-containing protein 74B isoform X3

   See identical proteins and their annotated locations for XP_011528477.1

   Conserved Domains (2) summary

   cd00116
   Location:58 → 205

   LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

   sd00033
   Location:54 → 80

   LRR_RI; leucine-rich repeat [structural motif]

2. XM_011530177.2 → XP_011528479.1  leucine-rich repeat-containing protein 74B isoform X3

   See identical proteins and their annotated locations for XP_011528479.1

   Conserved Domains (2) summary

   cd00116
   Location:58 → 205

   LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

   sd00033
   Location:54 → 80

   LRR_RI; leucine-rich repeat [structural motif]

3. XM_011530176.3 → XP_011528478.1  leucine-rich repeat-containing protein 74B isoform X3

   See identical proteins and their annotated locations for XP_011528478.1

   Conserved Domains (2) summary

   cd00116
   Location:58 → 205

   LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

   sd00033
   Location:54 → 80

   LRR_RI; leucine-rich repeat [structural motif]

4. XM_011530174.2 → XP_011528476.1  leucine-rich repeat-containing protein 74B isoform X3

   See identical proteins and their annotated locations for XP_011528476.1

   Conserved Domains (2) summary

   cd00116
   Location:58 → 205

   LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

   sd00033
   Location:54 → 80

   LRR_RI; leucine-rich repeat [structural motif]

5. XM_047441362.1 → XP_047297318.1  leucine-rich repeat-containing protein 74B isoform X1

6. XM_017028797.2 → XP_016884286.1  leucine-rich repeat-containing protein 74B isoform X2

RNA

1. XR_937849.2 RNA Sequence

2. XR_937851.2 RNA Sequence

3. XR_937858.2 RNA Sequence

4. XR_937847.2 RNA Sequence

5. XR_937859.2 RNA Sequence

6. XR_937862.2 RNA Sequence

7. XR_937856.2 RNA Sequence

8. XR_937861.2 RNA Sequence

9. XR_937860.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

1. NC_060946.1 Alternate T2T-CHM13v2.0

   Range

   21454733..21472942

   Download

   GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

1. XM_054325610.1 → XP_054181585.1  leucine-rich repeat-containing protein 74B isoform X3

2. XM_054325612.1 → XP_054181587.1  leucine-rich repeat-containing protein 74B isoform X3

3. XM_054325611.1 → XP_054181586.1  leucine-rich repeat-containing protein 74B isoform X3

4. XM_054325609.1 → XP_054181584.1  leucine-rich repeat-containing protein 74B isoform X3

5. XM_054325607.1 → XP_054181582.1  leucine-rich repeat-containing protein 74B isoform X1

6. XM_054325608.1 → XP_054181583.1  leucine-rich repeat-containing protein 74B isoform X2

RNA

1. XR_008485388.1 RNA Sequence

2. XR_008485389.1 RNA Sequence

3. XR_008485391.1 RNA Sequence

4. XR_008485387.1 RNA Sequence

5. XR_008485392.1 RNA Sequence

6. XR_008485395.1 RNA Sequence

7. XR_008485390.1 RNA Sequence

8. XR_008485394.1 RNA Sequence

9. XR_008485393.1 RNA Sequence

The following Reference Sequences have been suppressed. Explain

These RefSeqs were suppressed for the cited reason(s). Suppressed RefSeqs do not appear in BLAST databases, related sequence links, or BLAST links (BLink), but may still be retrieved by clicking on their accession.version below.

1. NM_001013675.1: Suppressed sequence

   Description

   NM_001013675.1: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.