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    phoQ two-component sensor PhoQ [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 879187, updated on 11-Sep-2024

    Summary

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    Gene symbol
    phoQ
    Gene description
    two-component sensor PhoQ
    Locus tag
    PA1180
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (1278362..1279708)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene nitrate reductase protein NapE Neighboring gene PhoP/Q and low Mg2+ inducible outer membrane protein H1 Neighboring gene two-component response regulator PhoP Neighboring gene sensor protein Neighboring gene transcriptional regulator

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sensing Mg(2+) contributes to the resistance of Pseudomonas aeruginosa to complement-mediated opsonophagocytosis. Qadi M, et al. Environ Microbiol, 2017 Oct. PMID 28805355
    2. The sensor kinase PhoQ mediates virulence in Pseudomonas aeruginosa. Gooderham WJ, et al. Microbiology (Reading), 2009 Mar. PMID 19246741
    3. PhoQ mutations promote lipid A modification and polymyxin resistance of Pseudomonas aeruginosa found in colistin-treated cystic fibrosis patients. Miller AK, et al. Antimicrob Agents Chemother, 2011 Dec. PMID 21968359, Free PMC Article
    4. Magnesium limitation is an environmental trigger of the Pseudomonas aeruginosa biofilm lifestyle. Mulcahy H, et al. PLoS One, 2011. PMID 21858064, Free PMC Article
    5. The Pseudomonas aeruginosa PhoP-PhoQ two-component regulatory system is induced upon interaction with epithelial cells and controls cytotoxicity and inflammation. Gellatly SL, et al. Infect Immun, 2012 Sep. PMID 22710876, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. expression of PhoQ is essential to detect Mg(2+) and reduce the expression of OprH, a previously unrecognized C3 binding molecule that promotes the opsonophagocytosis of P. aeruginosa.
      Title: Sensing Mg(2+) contributes to the resistance of Pseudomonas aeruginosa to complement-mediated opsonophagocytosis.
    2. The interaction of wild-type (WT) bacteria that had adhered to epithelial cells led to a large upregulation of the expression of the oprH-phoP-phoQ operon, in a PhoQ-dependent manner
      Title: The Pseudomonas aeruginosa PhoP-PhoQ two-component regulatory system is induced upon interaction with epithelial cells and controls cytotoxicity and inflammation.
    3. Data suggest that PhoPQ controls the equilibrium of the small regulatory RNAs and thus fine-tunes the expression of genes in the RetS pathway.
      Title: Magnesium limitation is an environmental trigger of the Pseudomonas aeruginosa biofilm lifestyle.
    4. Results suggest that polymyxin B resistance among clinical isolates of P. aeruginosa is associated with alterations in two-component regulatory systems of phoPQ or pmrAB.
      Title: Alterations in two-component regulatory systems of phoPQ and pmrAB are associated with polymyxin B resistance in clinical isolates of Pseudomonas aeruginosa.
    5. phoQ mutants showed reduced virulence in lettuce leaves, reduced cytotoxicity toward cultured human lung epithelial cells, and are highly attenuated for virulence in a model of chronic lung infection.
      Title: The sensor kinase PhoQ mediates virulence in Pseudomonas aeruginosa.
    6. Pseudomons antibiotic resistance is regulated by the PhoP-PhoQ and PmrA-PmrB two-component regulatory systems.
      Title: Contribution of the PhoP-PhoQ and PmrA-PmrB two-component regulatory systems to Mg2+-induced gene regulation in Pseudomonas aeruginosa.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to antibiotic ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    two-component sensor PhoQ
    NP_249871.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      1278362..1279708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_249871.1 two-component sensor PhoQ [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_249871.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      C7EDC6, G9JL92
      Conserved Domains (1) summary
      PRK10815
      Location:190 → 446
      PRK10815; two-component system sensor histidine kinase PhoQ
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9I4F8.1

    Gene LinkOut

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    Research Materials