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    mucD serine protease MucD [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 879207, updated on 11-Sep-2024

    Summary

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    Gene symbol
    mucD
    Gene description
    serine protease MucD
    Locus tag
    PA0766
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (833949..835373)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene sigma factor AlgU negative regulator MucA Neighboring gene sigma factor AlgU regulator MucB Neighboring gene positive regulator for alginate biosynthesis MucC Neighboring gene elongation factor 4 Neighboring gene signal peptidase I

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A natural antisense transcript regulates mucD gene expression and biofilm biosynthesis in Pseudomonas aeruginosa. Yang Z, et al. Mikrobiologiia, 2011 Nov-Dec. PMID 22393760
    2. Identification of a periplasmic AlgK-AlgX-MucD multiprotein complex in Pseudomonas aeruginosa involved in biosynthesis and regulation of alginate. Hay ID, et al. Appl Microbiol Biotechnol, 2012 Jan. PMID 21713511
    3. Pseudomonas aeruginosa MucD regulates the alginate pathway through activation of MucA degradation via MucP proteolytic activity. Damron FH, et al. J Bacteriol, 2011 Jan. PMID 21036998, Free PMC Article
    4. Independent regulation of MucD, an HtrA-like protease in Pseudomonas aeruginosa, and the role of its proteolytic motif in alginate gene regulation. Wood LF, et al. J Bacteriol, 2006 Apr. PMID 16585775, Free PMC Article
    5. Biochemical analysis of alginate biosynthesis protein AlgX from Pseudomonas aeruginosa: purification of an AlgX-MucD (AlgY) protein complex. Gutsche J, et al. Biochimie, 2006 Mar-Apr. PMID 16376476

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A natural antisense transcript regulates mucD gene expression and biofilm biosynthesis in Pseudomonas aeruginosa.
      Title: A natural antisense transcript regulates mucD gene expression and biofilm biosynthesis in Pseudomonas aeruginosa.
    2. Expression of single-copy mucD217, encoding MucD altered in the protease motif (S217A), was defective in temperature resistance and alginate gene regulation.
      Title: Independent regulation of MucD, an HtrA-like protease in Pseudomonas aeruginosa, and the role of its proteolytic motif in alginate gene regulation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine protease MucD
    NP_249457.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      833949..835373
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_249457.1 serine protease MucD [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_249457.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      G3XD20, Q57155
      Conserved Domains (1) summary
      TIGR02037
      Location:28 → 470
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
    Nucleotide Protein
    Heading Accession and Version

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