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    PRF1 profilin 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816495, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PRF1
    Official Full Name
    profilin 1
    Primary source
    TAIR:AT2G19760
    Locus tag
    AT2G19760
    See related
    Araport:AT2G19760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F6F22.21; F6F22_21; PFN1; profilin 1; PROFILIN 1
    Summary
    first member of the Arabidopsis profilin multigene family, expressed in all organs of Arabidopsis. Binds poly-L-proline. The first intron of PRF1 enhances gene expression in vegetative tissues.
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    Genomic context

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    See PRF1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    3
    Sequence:
    Chromosome: 2; NC_003071.7 (8516658..8518194, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Ribosomal protein S30 family protein Neighboring gene pseudo Neighboring gene profilin 5 Neighboring gene Leucine-rich repeat (LRR) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Profilin-Dependent Nucleation and Assembly of Actin Filaments Controls Cell Elongation in Arabidopsis. Cao L, et al. Plant Physiol, 2016 Jan. PMID 26574597, Free PMC Article
    2. Small changes in the regulation of one Arabidopsis profilin isovariant, PRF1, alter seedling development. McKinney EC, et al. Plant Cell, 2001 May. PMID 11340190, Free PMC Article
    3. Arabidopsis profilin isoforms, PRF1 and PRF2 show distinctive binding activities and subcellular distributions. Wang F, et al. J Integr Plant Biol, 2009 Feb. PMID 19200149
    4. Role of nucleotide exchange and hydrolysis in the function of profilin in action assembly. Perelroizen I, et al. J Biol Chem, 1996 May 24. PMID 8647830
    5. Arabidopsis plants deficient in constitutive class profilins reveal independent and quantitative genetic effects. Müssar KJ, et al. BMC Plant Biol, 2015 Jul 11. PMID 26160044, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PRF1 coordinates the stochastic dynamic properties of actin filaments by modulating formin-mediated actin nucleation and assembly during plant cell expansion.
      Title: Profilin-Dependent Nucleation and Assembly of Actin Filaments Controls Cell Elongation in Arabidopsis.
    2. formed a filamentous network likely associated with actin filaments
      Title: Arabidopsis profilin isoforms, PRF1 and PRF2 show distinctive binding activities and subcellular distributions.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_127534.3

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    acts_upstream_of_or_within actin polymerization or depolymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within inflorescence development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lateral root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within unidimensional cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in nucleolus HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in phragmoplast HDA PubMed 
    located_in plant-type cell wall HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasmodesma HDA PubMed 
    located_in spindle HDA PubMed 

    General protein information

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    Preferred Names
    profilin 1
    NP_179566.1
    • profilin 1 (PRF1); FUNCTIONS IN: actin binding; INVOLVED IN: actin polymerization or depolymerization, cytoskeleton organization, unidimensional cell growth; LOCATED IN: in 8 components; EXPRESSED IN: 30 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Profilin/allergen (InterPro:IPR002097), Profilin, plant (InterPro:IPR005455); BEST Arabidopsis thaliana protein match is: profilin 2 (TAIR:AT4G29350.1); Has 937 Blast hits to 936 proteins in 250 species: Archae - 0; Bacteria - 2; Metazoa - 144; Fungi - 125; Plants - 584; Viruses - 0; Other Eukaryotes - 82 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      8516658..8518194 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127534.3 → NP_179566.1  profilin 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179566.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q42449
      UniProtKB/TrEMBL
      A0A178VSE7, A0A5S9WZP5, A0A654EZD9
      Conserved Domains (1) summary
      pfam00235
      Location:1 → 128
      Profilin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q42449.1

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