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    LINC01013 long intergenic non-protein coding RNA 1013 [ Homo sapiens (human) ]

    Gene ID: 100507254, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LINC01013provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 1013provided by HGNC
    Primary source
    HGNC:HGNC:48987
    See related
    Ensembl:ENSG00000228495 AllianceGenome:HGNC:48987
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AERRIE; LINC02921
    Expression
    Biased expression in testis (RPKM 1.0), lymph node (RPKM 0.8) and 10 other tissues See more
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    Genomic context

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    See LINC01013 in Genome Data Viewer
    Location:
    6q23.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (132132572..132169374)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (133327603..133364404)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (132453712..132490514)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene CCN2 antisense RNA 1 Neighboring gene cellular communication network factor 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:132324214-132325413 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25069 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:132453077-132454276 Neighboring gene microRNA 548aj-1 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 36 Neighboring gene monooxygenase DBH like 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:132675510-132676709 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17547 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17548

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. LINC01013 Is a Determinant of Fibroblast Activation and Encodes a Novel Fibroblast-Activating Micropeptide. Quaife NM, et al. J Cardiovasc Transl Res, 2023 Feb. PMID 35759180, Free PMC Article
    2. Novel role of LINC01013/miR-6795-5p/FMNL3 axis in the regulation of hepatocellular carcinoma stem cell features. Wang W, et al. Acta Biochim Biophys Sin (Shanghai), 2021 May 21. PMID 33847733
    3. Long Non-coding RNA Aerrie Controls DNA Damage Repair via YBX1 to Maintain Endothelial Cell Function. Pham TP, et al. Front Cell Dev Biol, 2020. PMID 33505972, Free PMC Article
    4. The long non-coding RNA LINC01013 enhances invasion of human anaplastic large-cell lymphoma. Chung IH, et al. Sci Rep, 2017 Mar 22. PMID 28331184, Free PMC Article
    5. Negative Regulation of LINC01013 by METTL3 and YTHDF2 Enhances the Osteogenic Differentiation of Senescent Pre-Osteoblast Cells Induced by Hydrogen Peroxide. Song J, et al. Adv Biol (Weinh), 2024 May. PMID 38548669

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Negative Regulation of LINC01013 by METTL3 and YTHDF2 Enhances the Osteogenic Differentiation of Senescent Pre-Osteoblast Cells Induced by Hydrogen Peroxide.
      Title: Negative Regulation of LINC01013 by METTL3 and YTHDF2 Enhances the Osteogenic Differentiation of Senescent Pre-Osteoblast Cells Induced by Hydrogen Peroxide.
    2. LINC01013 Is a Determinant of Fibroblast Activation and Encodes a Novel Fibroblast-Activating Micropeptide.
      Title: LINC01013 Is a Determinant of Fibroblast Activation and Encodes a Novel Fibroblast-Activating Micropeptide.
    3. Genome-wide chromatin contacts of super-enhancer-associated lncRNA identify LINC01013 as a regulator of fibrosis in the aortic valve.
      Title: Genome-wide chromatin contacts of super-enhancer-associated lncRNA identify LINC01013 as a regulator of fibrosis in the aortic valve.
    4. Novel role of LINC01013/miR-6795-5p/FMNL3 axis in the regulation of hepatocellular carcinoma stem cell features.
      Title: Novel role of LINC01013/miR-6795-5p/FMNL3 axis in the regulation of hepatocellular carcinoma stem cell features.
    5. Collectively, these findings support a potential role for LINC01013 in cancer cell invasion through the snail-fibronectin activation cascade.
      Title: The long non-coding RNA LINC01013 enhances invasion of human anaplastic large-cell lymphoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Other Names

    • Age and EndMT Regulated RNA In Endothelium
    • LINC01013ORF
    • long intergenic non-protein coding RNA 2921

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_038981.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL021408
      Related
      ENST00000773284.1

    2. NR_146223.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL021408

    3. NR_187597.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL021408
      Related
      ENST00000669240.2

    4. NR_187598.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL021408

    5. NR_187599.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL021408
      Related
      ENST00000706315.2

    6. NR_187600.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL021408

    7. NR_187601.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL021408

    8. NR_187602.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL021408

    9. NR_187603.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL021408

    10. NR_187604.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL021408
      Related
      ENST00000654779.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      132132572..132169374
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      133327603..133364404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Research Materials