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    MPPalpha mitochondrial processing peptidase alpha subunit [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820896, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MPPalpha
    Official Full Name
    mitochondrial processing peptidase alpha subunit
    Primary source
    TAIR:AT3G16480
    Locus tag
    AT3G16480
    See related
    Araport:AT3G16480
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    mitochondrial processing peptidase alpha subunit; T2O4.13
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    Genomic context

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    See MPPalpha in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    13
    Sequence:
    Chromosome: 3; NC_003074.8 (5599710..5603027)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Mannose-binding lectin superfamily protein Neighboring gene Mannose-binding lectin superfamily protein Neighboring gene Mannose-binding lectin superfamily protein Neighboring gene IQ-domain 26 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dual targeting of a processing peptidase into both endosymbiotic organelles mediated by a transport signal of unusual architecture. Baudisch B, et al. Mol Plant, 2012 Mar. PMID 22131051
    2. Dual location of the mitochondrial preprotein transporters B14.7 and Tim23-2 in complex I and the TIM17:23 complex in Arabidopsis links mitochondrial activity and biogenesis. Wang Y, et al. Plant Cell, 2012 Jun. PMID 22730406, Free PMC Article
    3. Arabidopsis PPR40 connects abiotic stress responses to mitochondrial electron transport. Zsigmond L, et al. Plant Physiol, 2008 Apr. PMID 18305213, Free PMC Article
    4. A transcriptomic and proteomic characterization of the Arabidopsis mitochondrial protein import apparatus and its response to mitochondrial dysfunction. Lister R, et al. Plant Physiol, 2004 Feb. PMID 14730085, Free PMC Article
    5. Resolving and identifying protein components of plant mitochondrial respiratory complexes using three dimensions of gel electrophoresis. Meyer EH, et al. J Proteome Res, 2008 Feb. PMID 18189341

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_112519.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial intermembrane space HDA PubMed 
    located_in mitochondrial matrix HDA PubMed 
    located_in mitochondrial outer membrane HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole HDA PubMed 
    part_of respiratory chain complex III HDA PubMed 

    General protein information

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    Preferred Names
    mitochondrial processing peptidase alpha subunit
    NP_566548.1
    • mitochondrial processing peptidase alpha subunit (MPPalpha); FUNCTIONS IN: metalloendopeptidase activity, catalytic activity, zinc ion binding, metal ion binding; INVOLVED IN: proteolysis; LOCATED IN: in 8 components; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase M16, zinc-binding site (InterPro:IPR001431), Peptidase M16, C-terminal (InterPro:IPR007863), Peptidase M16, N-terminal (InterPro:IPR011765), Metalloenzyme, LuxS/M16 peptidase-like, metal-binding (InterPro:IPR011249), Peptidase M16, core (InterPro:IPR011237); BEST Arabidopsis thaliana protein match is: Insulinase (Peptidase family M16) protein (TAIR:AT1G51980.1); Has 6415 Blast hits to 6299 proteins in 1510 species: Archae - 10; Bacteria - 3712; Metazoa - 680; Fungi - 566; Plants - 250; Viruses - 3; Other Eukaryotes - 1194 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      5599710..5603027
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112519.4 → NP_566548.1  mitochondrial processing peptidase alpha subunit [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566548.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DHQ2, O04308, Q94C54
      UniProtKB/TrEMBL
      A0A178VGY5, A0A654F7S8
      Conserved Domains (1) summary
      COG0612
      Location:73 → 492
      PqqL; Predicted Zn-dependent peptidase [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O04308.1

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