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    Calcium-binding EF-hand family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820181, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Calcium-binding EF-hand family protein
    Primary source
    TAIR:AT3G10190
    Locus tag
    AT3G10190
    See related
    Araport:AT3G10190
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Summary
    Encodes a protein with sequence similarity to calmodulins. Loss of function mutations have decreased response to chitin elicitors suggesting a role in plant response to fungal pathogens.
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_003074.8 (3155223..3156187)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene DHFS-FPGS homolog C Neighboring gene Gibberellin-regulated family protein Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene Putative membrane lipoprotein Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene SEC14 cytosolic factor family protein / phosphoglyceride transfer family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis calmodulin-like protein CML36 is a calcium (Ca(2+)) sensor that interacts with the plasma membrane Ca(2+)-ATPase isoform ACA8 and stimulates its activity. Astegno A, et al. J Biol Chem, 2017 Sep 8. PMID 28726644, Free PMC Article
    2. LIK1, a CERK1-interacting kinase, regulates plant immune responses in Arabidopsis. Le MH, et al. PLoS One, 2014. PMID 25036661, Free PMC Article
    3. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CML36 interacts directly with the regulative N terminus of the Arabidopsis plasma membrane Ca(2+)-ATPase isoform 8 (ACA8) and this interaction stimulates ACA8 activity. [CML36]
      Title: Arabidopsis calmodulin-like protein CML36 is a calcium (Ca(2+)) sensor that interacts with the plasma membrane Ca(2+)-ATPase isoform ACA8 and stimulates its activity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_111854.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Calcium-binding EF-hand family protein
    NP_187630.1
    • Calcium-binding EF-hand family protein; FUNCTIONS IN: calcium ion binding; INVOLVED IN: biological_process unknown; LOCATED IN: plasma membrane; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF-HAND 2 (InterPro:IPR018249), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand (InterPro:IPR018248); BEST Arabidopsis thaliana protein match is: Calcium-binding EF-hand family protein (TAIR:AT2G41410.1); Has 18786 Blast hits to 12756 proteins in 1414 species: Archae - 1; Bacteria - 149; Metazoa - 7817; Fungi - 3299; Plants - 4581; Viruses - 0; Other Eukaryotes - 2939 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      3155223..3156187
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111854.5 → NP_187630.1  Calcium-binding EF-hand family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187630.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SS31
      UniProtKB/TrEMBL
      A0A178VG80, A0A5S9XAZ3
      Conserved Domains (2) summary
      cd00051
      Location:143 → 205
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:71 → 129
      EF-hand_7; EF-hand domain pair
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SS31.1

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