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    SERTAD4 SERTA domain containing 4 [ Homo sapiens (human) ]

    Gene ID: 56256, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SERTAD4provided by HGNC
    Official Full Name
    SERTA domain containing 4provided by HGNC
    Primary source
    HGNC:HGNC:25236
    See related
    Ensembl:ENSG00000082497 AllianceGenome:HGNC:25236
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DJ667H12.2
    Summary
    Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in endometrium (RPKM 2.8), salivary gland (RPKM 2.4) and 20 other tissues See more
    Orthologs
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    Genomic context

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    See SERTAD4 in Genome Data Viewer
    Location:
    1q32.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (210232796..210246631)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (209471480..209485315)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (210406141..210419976)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2477 Neighboring gene Sharpr-MPRA regulatory region 1786 Neighboring gene UTP25 small subunit processome component Neighboring gene NANOG hESC enhancer GRCh37_chr1:210048900-210049401 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:210068740-210069939 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:210071837-210072364 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_2736 Neighboring gene Sharpr-MPRA regulatory region 13960 Neighboring gene synaptotagmin 14 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:210166703-210167203 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_2861 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_2872 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_2922 Neighboring gene NANOG hESC enhancer GRCh37_chr1:210284477-210284996 Neighboring gene MPRA-validated peak677 silencer Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_2948 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:210406019-210406552 Neighboring gene SERTAD4 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:210411491-210412001 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:210424713-210425268 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:210425824-210426378 Neighboring gene Sharpr-MPRA regulatory region 1241 Neighboring gene ST13, Hsp70 interacting protein pseudogene 19 Neighboring gene long intergenic non-protein coding RNA 2602

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. KRAS mutation promotes the colonization of Fusobacterium nucleatum in colorectal cancer by down-regulating SERTAD4. Chen Y, et al. J Cell Mol Med, 2024 Oct. PMID 39462261, Free PMC Article
    2. I-mfa domain proteins specifically interact with SERTA domain proteins and repress their transactivating functions. Kusano S, et al. Biochimie, 2011 Sep. PMID 21664411
    3. An integrated workflow for charting the human interaction proteome: insights into the PP2A system. Glatter T, et al. Mol Syst Biol, 2009. PMID 19156129, Free PMC Article
    4. Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. Pilot-Storck F, et al. Mol Cell Proteomics, 2010 Jul. PMID 20368287, Free PMC Article
    5. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Yao Z, et al. Mol Cell, 2017 Jan 19. PMID 28065597, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KRAS mutation promotes the colonization of Fusobacterium nucleatum in colorectal cancer by down-regulating SERTAD4.
      Title: KRAS mutation promotes the colonization of Fusobacterium nucleatum in colorectal cancer by down-regulating SERTAD4.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SERTA domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001354173.2 → NP_001341102.1  SERTA domain-containing protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AI808539, AL035414, BP342499

    2. NM_001375428.1 → NP_001362357.1  SERTA domain-containing protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL035414
      Consensus CDS
      CCDS1494.1
      UniProtKB/Swiss-Prot
      B2RD32, Q9NUC0
      Conserved Domains (1) summary
      pfam06031
      Location:108 → 142
      SERTA; SERTA motif

    3. NM_019605.5 → NP_062551.1  SERTA domain-containing protein 4 isoform 1

      See identical proteins and their annotated locations for NP_062551.1

      Status: VALIDATED

      Source sequence(s)
      AL035414, AW340609, BC012083, BP342499
      Consensus CDS
      CCDS1494.1
      UniProtKB/Swiss-Prot
      B2RD32, Q9NUC0
      Related
      ENSP00000355979.3, ENST00000367012.4
      Conserved Domains (1) summary
      pfam06031
      Location:108 → 142
      SERTA; SERTA motif

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      210232796..210246631
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425536.1 → XP_047281492.1  SERTA domain-containing protein 4 isoform X1

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_011332687.1 Reference GRCh38.p14 PATCHES

      Range
      12538..26373
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331662.1 → XP_054187637.1  SERTA domain-containing protein 4 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      209471480..209485315
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337727.1 → XP_054193702.1  SERTA domain-containing protein 4 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NUC0.1 GenPept UniProtKB/Swiss-Prot:Q9NUC0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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