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    ATAD2 ATPase family AAA domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 29028, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ATAD2provided by HGNC
    Official Full Name
    ATPase family AAA domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:30123
    See related
    Ensembl:ENSG00000156802 MIM:611941; AllianceGenome:HGNC:30123
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ANCCA; CT137; PRO2000
    Summary
    A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 15.3), bone marrow (RPKM 13.1) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ATAD2 in Genome Data Viewer
    Location:
    8q24.13
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (123319850..123416350, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (124450947..124547457, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (124332090..124408687, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ZHX1-C8orf76 readthrough Neighboring gene small nucleolar RNA U13 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:124285783-124286150 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19496 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19497 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27871 Neighboring gene zinc fingers and homeoboxes 1 Neighboring gene hydroxysteroid 17-beta dehydrogenase 4 pseudogene Neighboring gene Sharpr-MPRA regulatory region 1385 Neighboring gene RNA, U6 small nuclear 875, pseudogene Neighboring gene microRNA 548aa-1 Neighboring gene microRNA 548d-1 Neighboring gene deoxyuridine triphosphatase pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:124405259-124405759 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27872 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19498 Neighboring gene Sharpr-MPRA regulatory region 2006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27874 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27873 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:124422560-124423060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:124423061-124423561 Neighboring gene MPRA-validated peak7156 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19499 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:124429186-124429780 Neighboring gene inosine monophosphate dehydrogenase 1 pseudogene 6 Neighboring gene N-terminal glutamine amidase 1 Neighboring gene uncharacterized LOC124902105 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:124491440-124491940 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:124491941-124492441 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:124518725-124519269 Neighboring gene F-box protein 32 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:124539974-124541173 Neighboring gene MPRA-validated peak7157 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27875 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19502

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ATAD2 predicts poor outcomes in patients with ovarian cancer and is a marker of proliferation. Liu Q, et al. Int J Oncol, 2020 Jan. PMID 31746426, Free PMC Article
    2. Oncogene ATAD2 promotes cell proliferation, invasion and migration in cervical cancer. Zheng L, et al. Oncol Rep, 2015 May. PMID 25813398
    3. Overexpression of ANCCA/ATAD2 in endometrial carcinoma and its correlation with tumor progression and poor prognosis. Shang P, et al. Tumour Biol, 2015 Jun. PMID 25934333
    4. Coordination of Di-Acetylated Histone Ligands by the ATAD2 Bromodomain. Evans CM, et al. Int J Mol Sci, 2021 Aug 24. PMID 34502039, Free PMC Article
    5. Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells. Morozumi Y, et al. J Mol Cell Biol, 2016 Aug. PMID 26459632, Free PMC Article

    See all (109) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. circATAD2 mitigates CD8[+] T cells antitumor immune surveillance in breast cancer via IGF2BP3/m[6]A/PD-L1 manner.
      Title: circATAD2 mitigates CD8(+) T cells antitumor immune surveillance in breast cancer via IGF2BP3/m(6)A/PD-L1 manner.
    2. Structure of the human ATAD2 AAA+ histone chaperone reveals mechanism of regulation and inter-subunit communication.
      Title: Structure of the human ATAD2 AAA+ histone chaperone reveals mechanism of regulation and inter-subunit communication.
    3. MicroRNA-139-5p suppresses non-small cell lung cancer progression by targeting ATAD2.
      Title: MicroRNA-139-5p suppresses non-small cell lung cancer progression by targeting ATAD2.
    4. ATAD2 Upregulation Promotes Tumor Growth and Angiogenesis in Endometrial Cancer and Is Associated with Its Immune Infiltration.
      Title: ATAD2 Upregulation Promotes Tumor Growth and Angiogenesis in Endometrial Cancer and Is Associated with Its Immune Infiltration.
    5. Tumor-Promoting ATAD2 and Its Preclinical Challenges.
      Title: Tumor-Promoting ATAD2 and Its Preclinical Challenges.
    6. Oncogenic potential of ATAD2 in stomach cancer and insights into the protein-protein interactions at its AAA + ATPase domain and bromodomain.
      Title: Oncogenic potential of ATAD2 in stomach cancer and insights into the protein-protein interactions at its AAA + ATPase domain and bromodomain.
    7. Effect of chronic intermittent hypoxia-induced HIF-1alpha/ATAD2 expression on lung cancer stemness.
      Title: Effect of chronic intermittent hypoxia-induced HIF-1α/ATAD2 expression on lung cancer stemness.
    8. ATAD2 controls chromatin-bound HIRA turnover.
      Title: ATAD2 controls chromatin-bound HIRA turnover.
    9. ATAD2 drives colorectal cancer progression by regulating TRIM25 expression via a positive feedback loop with E2F transcriptional factors.
      Title: ATAD2 drives colorectal cancer progression by regulating TRIM25 expression via a positive feedback loop with E2F transcriptional factors.
    10. ATAD2 interacts with C/EBPbeta to promote esophageal squamous cell carcinoma metastasis via TGF-beta1/Smad3 signaling.
      Title: ATAD2 interacts with C/EBPβ to promote esophageal squamous cell carcinoma metastasis via TGF-β1/Smad3 signaling.
    Submit: New GeneRIF Correction See all GeneRIFs (57)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC5254, MGC29843, MGC131938, MGC142216, DKFZp667N1320

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleosome disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription initiation-coupled chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ATPase family AAA domain-containing protein 2
    Names
    AAA nuclear coregulator cancer-associated protein
    NP_054828.2
    XP_011515296.1
    XP_011515297.1
    XP_011515298.1
    XP_047277678.1
    XP_047277679.1
    XP_047277680.1
    XP_047277681.1
    XP_054216337.1
    XP_054216338.1
    XP_054216339.1
    XP_054216340.1
    XP_054216341.1
    XP_054216342.1
    XP_054216343.1
    XP_054216344.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014109.4 → NP_054828.2  ATPase family AAA domain-containing protein 2

      See identical proteins and their annotated locations for NP_054828.2

      Status: REVIEWED

      Source sequence(s)
      BC113656, BP314109, CA441499, CB159561
      Consensus CDS
      CCDS6343.1
      UniProtKB/Swiss-Prot
      Q14CR1, Q658P2, Q68CQ0, Q6PJV6, Q6PL18, Q8N890, Q9UHS5
      Related
      ENSP00000287394.5, ENST00000287394.10
      Conserved Domains (4) summary
      cd05528
      Location:987 → 1097
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      smart00382
      Location:459 → 600
      AAA; ATPases associated with a variety of cellular activities
      COG5076
      Location:915 → 1153
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam00004
      Location:464 → 598
      AAA; ATPase family associated with various cellular activities (AAA)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      123319850..123416350 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421723.1 → XP_047277679.1  ATPase family AAA domain-containing protein 2 isoform X2

    2. XM_047421722.1 → XP_047277678.1  ATPase family AAA domain-containing protein 2 isoform X2

    3. XM_011516994.4 → XP_011515296.1  ATPase family AAA domain-containing protein 2 isoform X1

      Conserved Domains (4) summary
      cd05528
      Location:987 → 1097
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      smart00382
      Location:459 → 600
      AAA; ATPases associated with a variety of cellular activities
      COG5076
      Location:915 → 1160
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam00004
      Location:464 → 598
      AAA; ATPase family associated with various cellular activities (AAA)

    4. XM_011516996.4 → XP_011515298.1  ATPase family AAA domain-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A0B4J211
      Related
      ENSP00000429213.1, ENST00000521903.5
      Conserved Domains (2) summary
      cd05528
      Location:446 → 556
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      cl21455
      Location:17 → 57
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    5. XM_047421724.1 → XP_047277680.1  ATPase family AAA domain-containing protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A0B4J211

    6. XM_011516995.4 → XP_011515297.1  ATPase family AAA domain-containing protein 2 isoform X3

      Related
      ENST00000521496.5
      Conserved Domains (2) summary
      smart00382
      Location:459 → 600
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:464 → 598
      AAA; ATPase family associated with various cellular activities (AAA)

    7. XM_047421725.1 → XP_047277681.1  ATPase family AAA domain-containing protein 2 isoform X6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      124450947..124547457 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360364.1 → XP_054216339.1  ATPase family AAA domain-containing protein 2 isoform X2

    2. XM_054360363.1 → XP_054216338.1  ATPase family AAA domain-containing protein 2 isoform X2

    3. XM_054360362.1 → XP_054216337.1  ATPase family AAA domain-containing protein 2 isoform X1

    4. XM_054360365.1 → XP_054216340.1  ATPase family AAA domain-containing protein 2 isoform X2

    5. XM_054360367.1 → XP_054216342.1  ATPase family AAA domain-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A0B4J211

    6. XM_054360368.1 → XP_054216343.1  ATPase family AAA domain-containing protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A0B4J211

    7. XM_054360366.1 → XP_054216341.1  ATPase family AAA domain-containing protein 2 isoform X3

    8. XM_054360369.1 → XP_054216344.1  ATPase family AAA domain-containing protein 2 isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PL18.1 GenPept UniProtKB/Swiss-Prot:Q6PL18

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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