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    DYRK1B dual specificity tyrosine phosphorylation regulated kinase 1B [ Homo sapiens (human) ]

    Gene ID: 9149, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DYRK1Bprovided by HGNC
    Official Full Name
    dual specificity tyrosine phosphorylation regulated kinase 1Bprovided by HGNC
    Primary source
    HGNC:HGNC:3092
    See related
    Ensembl:ENSG00000105204 MIM:604556; AllianceGenome:HGNC:3092
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MIRK; AOMS3
    Summary
    This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
    Expression
    Broad expression in testis (RPKM 21.5), prostate (RPKM 4.7) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DYRK1B in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (39825350..39834162, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (42630272..42639084, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40315990..40324802, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene leucine twenty homeobox Neighboring gene uncharacterized LOC124904719 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:40314468-40315454 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:40315455-40316439 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10613 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10614 Neighboring gene microRNA 6719 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:40335824-40336564 Neighboring gene fibrillarin Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:40357069-40358268 Neighboring gene Fc gamma binding protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:40376357-40376858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:40433231-40433732

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Targeting the survival kinase DYRK1B: A novel approach to overcome radiotherapy-related treatment resistance. Beckers C, et al. Radiother Oncol, 2024 Jan. PMID 38040123
    2. Mirk/dyrk1B kinase is upregulated following inhibition of mTOR. Deng X, et al. Carcinogenesis, 2014 Sep. PMID 24590896, Free PMC Article
    3. Pathogenic, Total Loss-of-Function DYRK1B Variants Cause Monogenic Obesity Associated With Type 2 Diabetes. Folon L, et al. Diabetes Care, 2024 Mar 1. PMID 38170957
    4. Ovarian cancer cells, not normal cells, are damaged by Mirk/Dyrk1B kinase inhibition. Hu J, et al. Int J Cancer, 2013 May 15. PMID 23114871, Free PMC Article
    5. Inactivation of mirk/dyrk1b kinase targets quiescent pancreatic cancer cells. Ewton DZ, et al. Mol Cancer Ther, 2011 Nov. PMID 21878655, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pathogenic, Total Loss-of-Function DYRK1B Variants Cause Monogenic Obesity Associated With Type 2 Diabetes.
      Title: Pathogenic, Total Loss-of-Function DYRK1B Variants Cause Monogenic Obesity Associated With Type 2 Diabetes.
    2. Targeting the survival kinase DYRK1B: A novel approach to overcome radiotherapy-related treatment resistance.
      Title: Targeting the survival kinase DYRK1B: A novel approach to overcome radiotherapy-related treatment resistance.
    3. Analysis of DYRK1B, PPARG, and CEBPB Expression Patterns in Adipose-Derived Stem Cells from Patients Carrying DYRK1B R102C and Healthy Individuals During Adipogenesis.
      Title: Analysis of DYRK1B, PPARG, and CEBPB Expression Patterns in Adipose-Derived Stem Cells from Patients Carrying DYRK1B R102C and Healthy Individuals During Adipogenesis.
    4. DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics.
      Title: DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics.
    5. Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B.
      Title: Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B.
    6. Suppression of DYRK1A/B Drives Endoplasmic Reticulum Stress-mediated Autophagic Cell Death Through Metabolic Reprogramming in Colorectal Cancer Cells.
      Title: Suppression of DYRK1A/B Drives Endoplasmic Reticulum Stress-mediated Autophagic Cell Death Through Metabolic Reprogramming in Colorectal Cancer Cells.
    7. Study of DYRK1B gene expression and its association with metabolic syndrome in a small cohort of Egyptians.
      Title: Study of DYRK1B gene expression and its association with metabolic syndrome in a small cohort of Egyptians.
    8. Screen identifies DYRK1B network as mediator of transcription repression on damaged chromatin.
      Title: Screen identifies DYRK1B network as mediator of transcription repression on damaged chromatin.
    9. Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation.
      Title: Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation.
    10. Human cytomegalovirus(HCMV) modulates cellular dual specificity tyrosine phosphorylation regulated kinase 1B (DYRK1B) during placental replication which may have implications for congenital HCMV pathogenesis and represent promising antiviral targets.
      Title: Human cytomegalovirus utilises cellular dual-specificity tyrosine phosphorylation-regulated kinases during placental replication.
    Submit: New GeneRIF Correction See all GeneRIFs (33)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Abdominal obesity-metabolic syndrome 3
    MedGen: C4014361 OMIM: 615812 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adipose tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in myoblast fusion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity tyrosine-phosphorylation-regulated kinase 1B
    Names
    dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
    minibrain-related kinase
    mirk protein kinase
    NP_004705.1
    NP_006474.1
    NP_006475.1
    XP_005259455.1
    XP_047295623.1
    XP_047295624.1
    XP_047295625.1
    XP_054178558.1
    XP_054178559.1
    XP_054178560.1
    XP_054178561.1
    XP_054187621.1
    XP_054187622.1
    XP_054187623.1
    XP_054187624.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034145.1 RefSeqGene

      Range
      5072..13884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004714.3 → NP_004705.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p69

      See identical proteins and their annotated locations for NP_004705.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as 'a') represents the longest transcript and encodes the longest isoform (p69, also known as isoform a).
      Source sequence(s)
      Y17999
      Consensus CDS
      CCDS12543.1
      UniProtKB/Swiss-Prot
      O75258, O75788, O75789, Q9Y463
      UniProtKB/TrEMBL
      B3KQI0
      Related
      ENSP00000312789.4, ENST00000323039.10
      Conserved Domains (1) summary
      cd14226
      Location:97 → 436
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

    2. NM_006483.3 → NP_006474.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p65

      See identical proteins and their annotated locations for NP_006474.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as 'b') uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (p65, also known as isoform b) is shorter than isoform p69.
      Source sequence(s)
      BI964831, Y17999
      Consensus CDS
      CCDS46075.1
      UniProtKB/TrEMBL
      B3KQI0
      Related
      ENSP00000403182.1, ENST00000430012.6
      Conserved Domains (1) summary
      cd14226
      Location:97 → 396
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

    3. NM_006484.3 → NP_006475.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p66

      See identical proteins and their annotated locations for NP_006475.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as 'c') lacks an alternate in-frame segment in the 3' coding region, compared to variant 1. The encoded isoform (p66, also known as isoform c) is shorter than isoform p69.
      Source sequence(s)
      BI964831, Y17999
      Consensus CDS
      CCDS12544.1
      UniProtKB/TrEMBL
      B3KQI0
      Related
      ENSP00000221803.4, ENST00000348817.7
      Conserved Domains (1) summary
      cd14226
      Location:97 → 408
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      39825350..39834162 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439669.1 → XP_047295625.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X3

      UniProtKB/TrEMBL
      B3KQI0

    2. XM_047439668.1 → XP_047295624.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X2

      UniProtKB/TrEMBL
      B3KQI0

    3. XM_047439667.1 → XP_047295623.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X1

      UniProtKB/TrEMBL
      A0A9H4CVU7, B3KQI0
      Related
      ENSP00000469863.2, ENST00000593685.5

    4. XM_005259398.5 → XP_005259455.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X4

      See identical proteins and their annotated locations for XP_005259455.1

      UniProtKB/Swiss-Prot
      O75258, O75788, O75789, Q9Y463
      UniProtKB/TrEMBL
      B3KQI0
      Conserved Domains (1) summary
      cd14226
      Location:97 → 436
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_009646206.1 Reference GRCh38.p14 PATCHES

      Range
      85226..94038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331646.1 → XP_054187621.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X1

      UniProtKB/TrEMBL
      A0A9H4CVU7, B3KQI0

    2. XM_054331647.1 → XP_054187622.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X2

      UniProtKB/TrEMBL
      B3KQI0

    3. XM_054331648.1 → XP_054187623.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X3

      UniProtKB/TrEMBL
      B3KQI0

    4. XM_054331649.1 → XP_054187624.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X4

      UniProtKB/Swiss-Prot
      O75258, O75788, O75789, Q9Y463
      UniProtKB/TrEMBL
      B3KQI0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      42630272..42639084 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322583.1 → XP_054178558.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X1

      UniProtKB/TrEMBL
      A0A9H4CVU7, B3KQI0

    2. XM_054322584.1 → XP_054178559.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X2

      UniProtKB/TrEMBL
      B3KQI0

    3. XM_054322585.1 → XP_054178560.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X3

      UniProtKB/TrEMBL
      B3KQI0

    4. XM_054322586.1 → XP_054178561.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X4

      UniProtKB/Swiss-Prot
      O75258, O75788, O75789, Q9Y463
      UniProtKB/TrEMBL
      B3KQI0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y463.1 GenPept UniProtKB/Swiss-Prot:Q9Y463

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