FUS9 Ubiquitin-conjugating enzyme family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: FUS9
Official Full Name: Ubiquitin-conjugating enzyme family protein
Primary source: TAIR:AT3G13550
Locus tag: AT3G13550
See related: Araport:AT3G13550
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: CIN4; CONSTITUTIVE PHOTOMORPHOGENIC 10; COP10; CYTOKININ-INSENSITIVE 4; E2 UBIQUITIN-CONJUGATING ENZYME; EMB144; EMBRYO DEFECTIVE 144; FUSCA 9
Summary: Encodes a protein similar to ubiquitin-conjugating enzyme (E2) variant proteins (UEV); lacks catalytic cysteine residue found in ubiquitin-conjugating enzyme E2. Represses photomorphogenesis and induces skotomorphogenesis in the dark.
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Genomic context

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See FUS9 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 4

Sequence:: Chromosome: 3; NC_003074.8 (4423237..4424894, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutation of CONSTITUTIVELY PHOTOMORPOGENIC1 (COP1), DE-ETIOLATED1, and CYTOKININ INSENSITIVE4/COP10 renders plants insensitive to cytokinin, and these factors are indispensable for the transcriptional response during cytokinin-induced de-etiolation, indicating that a functional light-signaling pathway is essential for this cytokinin response.
Title: Ethylene-independent promotion of photomorphogenesis in the dark by cytokinin requires COP1 and the CDD complex.
COP10 operates genetically in parallel to SDD1 and does not generally affect epidermal cell differentiation, but seems to operate on stomatal lineages where it controls specific cell-lineage and cell-signaling developmental mechanisms.
Title: Dynamic analysis of epidermal cell divisions identifies specific roles for COP10 in Arabidopsis stomatal lineage development.
COP10 prevents stomatal clusters and restricts stomata production in hypocotyls.
Title: Roles of constitutive photomorphogenic 10 in Arabidopsis stomata development.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001035614.2

Supported by ESTs:

NM_112201.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of photomorphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Ubiquitin-conjugating enzyme family protein

NP_001030691.1

FUSCA 9 (FUS9); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin-conjugating enzyme 29 (TAIR:AT2G16740.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_566459.2

FUSCA 9 (FUS9); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin-conjugating enzyme 29 (TAIR:AT2G16740.1); Has 10317 Blast hits to 10310 proteins in 396 species: Archae - 0; Bacteria - 0; Metazoa - 4584; Fungi - 2034; Plants - 2020; Viruses - 23; Other Eukaryotes - 1656 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

4423237..4424894 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_112201.5 → NP_566459.2 Ubiquitin-conjugating enzyme family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_566459.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A178VI85, Q0WNL1, Q9LJD7

UniProtKB/TrEMBL

A0A384LCG2, A0A5S9XC12, A0A7G2EPW0

Conserved Domains (1) summary

cd00195
Location:39 → 177

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
NM_001035614.2 → NP_001030691.1 Ubiquitin-conjugating enzyme family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001030691.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A7G2EPW0, B9DGC9

Conserved Domains (2) summary

COG5078
Location:33 → 150

COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

pfam00179
Location:40 → 150

UQ_con; Ubiquitin-conjugating enzyme