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    CCL23 C-C motif chemokine ligand 23 [ Homo sapiens (human) ]

    Gene ID: 6368, updated on 10-Dec-2024

    Summary

    Official Symbol
    CCL23provided by HGNC
    Official Full Name
    C-C motif chemokine ligand 23provided by HGNC
    Primary source
    HGNC:HGNC:10622
    See related
    Ensembl:ENSG00000274736 MIM:602494; AllianceGenome:HGNC:10622
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CKb8; MIP3; Ckb-8; MIP-3; MPIF-1; SCYA23; Ckb-8-1; hmrp-2a; CK-BETA-8
    Summary
    This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
    Expression
    Broad expression in appendix (RPKM 3.6), lung (RPKM 2.2) and 15 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CCL23 in Genome Data Viewer
    Location:
    17q12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (36013058..36017972, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (36960963..36965877, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34340098..34345009, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CCL15-CCL14 readthrough (NMD candidate) Neighboring gene C-C motif chemokine ligand 14 Neighboring gene uncharacterized LOC107985068 Neighboring gene C-C motif chemokine ligand 15 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:34350127-34350628 Neighboring gene uncharacterized LOC105371746 Neighboring gene C-C motif chemokine ligand 18

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (13 hits/1244 screens)

    EBI GWAS Catalog

    Description
    Genome-wide association study of lung function phenotypes in a founder population.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr upregulates the gene expression of CCL23 in human monocyte-derived dendritic cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables CCR chemokine receptor binding  
    enables CCR1 chemokine receptor binding PubMed 
    enables chemokine activity  
    enables chemokine activity PubMed 
    enables heparin binding  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    located_in extracellular region  
    is_active_in extracellular space  

    General protein information

    Preferred Names
    C-C motif chemokine 23
    Names
    C6 beta-chemokine
    chemokine (C-C motif) ligand 23
    macrophage inflammatory protein 3
    myeloid progenitor inhibitory factor 1
    small inducible cytokine subfamily A (Cys-Cys), member 23

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029876.2 RefSeqGene

      Range
      4997..9911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005064.6 → NP_005055.3  C-C motif chemokine 23 isoform CKbeta8-1 precursor

      See identical proteins and their annotated locations for NP_005055.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (CKbeta8-1) represents the longer transcript and encodes the longer isoform (CKbeta8-1).
      Source sequence(s)
      AC244100, BC143310, U58913, U85767
      Consensus CDS
      CCDS11305.1
      UniProtKB/Swiss-Prot
      P55773
      Related
      ENSP00000481357.1, ENST00000615050.2
      Conserved Domains (1) summary
      smart00199
      Location:68 → 126
      SCY; Intercrine alpha family (small cytokine C-X-C) (chemokine CXC)
    2. NM_145898.4 → NP_665905.2  C-C motif chemokine 23 isoform CKbeta8 precursor

      See identical proteins and their annotated locations for NP_665905.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (CKbeta8) uses an alternate, in-frame splice site in the coding region, compared to transcript variant CKbeta8-1. This difference results in a shorter protein (isoform CKbeta8) compared to isoform CKbeta8-1.
      Source sequence(s)
      AC244100, BC093970, U58913, U85767
      Consensus CDS
      CCDS59282.1
      UniProtKB/Swiss-Prot
      B7ZKQ3, O00174, O75950, P55773, Q52LD4
      Related
      ENSP00000484748.1, ENST00000612516.4
      Conserved Domains (1) summary
      smart00199
      Location:51 → 109
      SCY; Intercrine alpha family (small cytokine C-X-C) (chemokine CXC)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      36013058..36017972 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      247626..252537 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      36960963..36965877 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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