FRI FRIGIDA-like protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: FRI
Official Full Name: FRIGIDA-like protein
Primary source: TAIR:AT4G00650
Locus tag: AT4G00650
See related: Araport:AT4G00650
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F6N23.25; F6N23_25; FLA; FLOWERING LOCUS A; FRIGIDA; REDUCED STEM BRANCHING 7; RSB7
Summary: Encodes a major determinant of natural variation in Arabidopsis flowering time. Dominant alleles of FRI confer a vernalization requirement causing plants to overwinter vegetatively. Many early flowering accessions carry loss-of-function fri alleles .Twenty distinct haplotypes that contain non-functional FRI alleles have been identified and the distribution analyzed in over 190 accessions. The common lab strains- Col and Ler each carry loss of function mutations in FRI.
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Genomic context

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See FRI in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 3

Sequence:: Chromosome: 4; NC_003075.7 (268901..271503)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cold-induced Arabidopsis FRIGIDA nuclear condensates for FLC repression.
Title: Cold-induced Arabidopsis FRIGIDA nuclear condensates for FLC repression.
Calling large indels in 1047 Arabidopsis with IndelEnsembler.
Title: Calling large indels in 1047 Arabidopsis with IndelEnsembler.
Antagonistic activities of cotranscriptional regulators within an early developmental window set FLC expression level.
Title: Antagonistic activities of cotranscriptional regulators within an early developmental window set FLC expression level.
Functional analysis of FRIGIDA using naturally occurring variation in Arabidopsis thaliana.
Title: Functional analysis of FRIGIDA using naturally occurring variation in Arabidopsis thaliana.
Local expression of FRI in the phloem and leaves activated FLC to delay flowering. Furthermore, we found that local expression of FRI in the roots also delayed flowering by activating other targets, MADS AFFECTING FLOWERING4 (MAF4) and MAF5, in the roots. Graft and genetic experiments revealed that the spatial expression of FRI in the root might generate a mobile signal.
Title: Expression of FRIGIDA in root inhibits flowering in Arabidopsis thaliana.
establishes a local chromosomal environment for FLOWERING LOCUS C mRNA production
Title: FRIGIDA establishes a local chromosomal environment for FLOWERING LOCUS C mRNA production.
Data indicate that FRIGIDA protein (FRI) as an activator of EARLY FLOWERING IN SHORT DAYS protein EFS (EFS) and that EFS was a histone H3 Lys36-specific methyltransferase.
Title: Arabidopsis FRIGIDA stimulates EFS histone H3 Lys36 methyltransferase activity.
Taken together, our findings reveal the novel function of FRI in enhancing drought resistance through its downstream P5CS1 pathway during water-deficit stress, which is dependent on its target, the FLC gene.
Title: Functional FRIGIDA allele enhances drought tolerance by regulating the P5CS1 pathway in Arabidopsis thaliana.
natural variation involving deletion alleles modulate temperature-sensitive flowering responses
Title: Natural variation involving deletion alleles of FRIGIDA modulate temperature-sensitive flowering responses in Arabidopsis thaliana.
Structural Analysis of FRIGIDA Flowering-Time Regulator
Title: Structural Analysis of FRIGIDA Flowering-Time Regulator.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_116290.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of flower development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of timing of transition from vegetative to reproductive phase	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of vegetative phase change	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vegetative to reproductive phase transition of meristem	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vernalization response	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: FRIGIDA-like protein

NP_567181.2

FRIGIDA (FRI); CONTAINS InterPro DOMAIN/s: Frigida-like (InterPro:IPR012474); BEST Arabidopsis thaliana protein match is: FRIGIDA-like protein (TAIR:AT5G48385.1); Has 841 Blast hits to 841 proteins in 38 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 841; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).