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    SCART1 scavenger receptor family member expressed on T cells 1 [ Homo sapiens (human) ]

    Gene ID: 619207, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SCART1provided by HGNC
    Official Full Name
    scavenger receptor family member expressed on T cells 1provided by HGNC
    Primary source
    HGNC:HGNC:32411
    See related
    Ensembl:ENSG00000214279 AllianceGenome:HGNC:32411
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be involved in immune system process. Located in brush border and cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in spleen (RPKM 1.2), endometrium (RPKM 0.8) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SCART1 in Genome Data Viewer
    Location:
    10q26.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (133453945..133469760)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (134408221..134424034)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (135267449..135283264)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135237945-135238452 Neighboring gene uncharacterized LOC124902564 Neighboring gene shadow of prion protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4252 Neighboring gene olfactory receptor family 6 subfamily L member 2 pseudogene Neighboring gene MPRA-validated peak1138 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4253 Neighboring gene olfactory receptor family 7 subfamily M member 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4254 Neighboring gene uncharacterized LOC105378575 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2983 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2984 Neighboring gene CYP2E1 5' regulatory region Neighboring gene uncharacterized LOC124902569

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Characterization of a novel human scavenger receptor cysteine-rich molecule SCART1 expressed by lymphocytes. Holm D, et al. Immunobiology, 2013 Mar. PMID 22795646
    2. Cloning and characterization of SCART1, a novel scavenger receptor cysteine-rich type I transmembrane molecule. Holm D, et al. Mol Immunol, 2009 May. PMID 19297026
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in T cell mediated immunity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    scavenger receptor cysteine-rich domain-containing protein SCART1
    Names
    CD163c-alpha
    scavenger receptor protein family member

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001396050.1 → NP_001382979.1  scavenger receptor cysteine-rich domain-containing protein SCART1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL161645
      Consensus CDS
      CCDS91391.1
      UniProtKB/Swiss-Prot
      C9K0L3, Q4G0T1
      Related
      ENSP00000491516.1, ENST00000640237.2
      Conserved Domains (2) summary
      smart00202
      Location:786 → 885
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:439 → 534
      SRCR; Scavenger receptor cysteine-rich domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      133453945..133469760
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      134408221..134424034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033584.1: Suppressed sequence

      Description
      NM_001033584.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.

    2. NR_002934.3: Suppressed sequence

      Description
      NR_002934.3: This RefSeq was removed because currently there is insufficient support for the transcript structure.

    3. NR_149718.1: Suppressed sequence

      Description
      NR_149718.1: This RefSeq was removed because it is now thought that this gene does encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4G0T1.2 GenPept UniProtKB/Swiss-Prot:Q4G0T1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials