RHOA ras homolog family member A [Homo sapiens (human)] - Gene

Summary

Official Symbol: RHOAprovided by HGNC
Official Full Name: ras homolog family member Aprovided by HGNC
Primary source: HGNC:HGNC:667
See related: Ensembl:ENSG00000067560 MIM:165390; AllianceGenome:HGNC:667
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ARHA; ARH12; RHO12; EDFAOB; RHOH12
Summary: This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]
Expression: Ubiquitous expression in fat (RPKM 218.4), lung (RPKM 210.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3p21.31

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (49359145..49411976, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (49388518..49441355, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (49396578..49449409, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-8 promotes lens capsular residual cells migration by down-regulates expression of E-cadherin and ZO-1 via the CXCR1/2-NF-kappaB-RhoA signal pathway.
Title: IL-8 promotes lens capsular residual cells migration by down-regulates expression of E-cadherin and ZO-1 via the CXCR1/2-NF-κB-RhoA signal pathway.
SphK1 deficiency ameliorates the development of atherosclerosis by inhibiting the S1P/S1PR3/Rhoa/ROCK pathway.
Title: SphK1 deficiency ameliorates the development of atherosclerosis by inhibiting the S1P/S1PR3/Rhoa/ROCK pathway.
Intrinsically Disordered Membrane Anchors of Rheb, RhoA, and DiRas3 Small GTPases: Molecular Dynamics, Membrane Organization, and Interactions.
Title: Intrinsically Disordered Membrane Anchors of Rheb, RhoA, and DiRas3 Small GTPases: Molecular Dynamics, Membrane Organization, and Interactions.
Genetic disruption of ATAT1 causes RhoA downregulation through abnormal truncation of C/EBPbeta.
Title: Genetic disruption of ATAT1 causes RhoA downregulation through abnormal truncation of C/EBPβ.
Hydrostatic pressure mediates epithelial-mesenchymal transition of cholangiocytes through RhoA/ROCK and TGF-beta/smad pathways.
Title: Hydrostatic pressure mediates epithelial-mesenchymal transition of cholangiocytes through RhoA/ROCK and TGF-β/smad pathways.
Inhibition of RhoGEF/RhoA alleviates regorafenib resistance and cancer stemness via Hippo signaling pathway in hepatocellular carcinoma.
Title: Inhibition of RhoGEF/RhoA alleviates regorafenib resistance and cancer stemness via Hippo signaling pathway in hepatocellular carcinoma.
LAMB3 Promotes Myofibrogenesis and Cytoskeletal Reorganization in Endometrial Stromal Cells via the RhoA/ROCK1/MYL9 Pathway.
Title: LAMB3 Promotes Myofibrogenesis and Cytoskeletal Reorganization in Endometrial Stromal Cells via the RhoA/ROCK1/MYL9 Pathway.
The Snail signaling branch downstream of the TGF-beta/Smad3 pathway mediates Rho activation and subsequent stress fiber formation.
Title: The Snail signaling branch downstream of the TGF-β/Smad3 pathway mediates Rho activation and subsequent stress fiber formation.
Lipopolysaccharide Stimulates A549 Cell Migration through p-Tyr 42 RhoA and Phospholipase D1 Activity.
Title: Lipopolysaccharide Stimulates A549 Cell Migration through p-Tyr 42 RhoA and Phospholipase D1 Activity.
Novel cardiovascular protective effects of RhoA signaling and its therapeutic implications.
Title: Novel cardiovascular protective effects of RhoA signaling and its therapeutic implications.

Submit: New GeneRIF Correction See all GeneRIFs (827)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies MedGen: C5231477 OMIM: 618727 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Inhibition of the RhoA/Rac1 signal cascade by guanine nucleotide dissociation inhibitors limits the HIV-1 gp120-dependent early phase of the viral life cycle	PubMed
	env	Filamin-A-dependent activation of the RhoA-ROCK-LIMK-cofilin pathway is a major event in HIV-1 gp120-induced receptor clustering	PubMed
Nef	nef	MYH9 is downregulated by HIV-1 infection, which indicates that MYH9 downregulation is likely part of the Nef-mediated signaling cascade that includes RhoA downregulation	PubMed
Tat	tat	HIV-1 Tat increases permeability of human glomerular endothelial cells by activating Rho-A, pMLC, and c-Src pathways, which involves VEGF-A and FGF-2	PubMed
	tat	HIV-1 Tat downregulates OCLN (occludin) and LRP1 and upregulates AGER (RAGE), and in a RhoA/ROCK1 dependent manner as shown through hydroxyfasudil inhibition in hCMEC/D3 cells	PubMed
	tat	The basic domain (49RKKRRQRRR57) of HIV-1 Tat is essential for enhancing the FGF-induced activation of ERK, Rho-A, and MLC2 and upregulates the expression of MMP-9 in human podocytes	PubMed
	tat	Disruption of lipid rafts by depletion of membrane cholesterol with methyl-beta-cyclodextrin abolishes Tat-mediated RhoA activation and P-glycoprotein (P-gp) upregulation	PubMed
	tat	HIV-1 Tat-mediated downregulation of occludin expression requires activities of the RhoA and p160-Rho-associated coiled kinase (ROCK) proteins in primary human brain micro vascular endothelial cells	PubMed
	tat	Treatment of human brain endothelial cells with Tat markedly elevates GTP-RhoA levels and the potential downstream effectors, such as myosin phosphatase target subunit 1 and myosin light chain	PubMed
	tat	Knocking down oxidase Nox4 completely suppresses Tat-dependent Ras and ERK activation downstream of Rac1 and RhoA and blocks Tat-dependent proliferation	PubMed
	tat	Tat activates both Ras and Rho GTPases in endothelial cells, leading to ERK phosphorylation	PubMed
	tat	HIV-1 Tat exerts several pleiotropic effects by interacting with different cellular receptors, including integrin alpha(v)beta3, which triggers the activation of focal adhesion kinase, RhoA and pp60src	PubMed
Vpr	vpr	HIV-1 Vpr-expressing Jurkat T cell clones showed a significant upregulation of RhoA expression	PubMed
capsid	gag	Prostaglandin E2-mediated HIV-1 inhibition requires the EPAC/RAP/RhoA signaling pathway by downregulation of HIV-1 CA production	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:181197 (e-PCR)
- UniSTS:155171

A004G04 (e-PCR)
- UniSTS:31829

D3S1330E (e-PCR)
- UniSTS:147343

RH46190 (e-PCR)
- UniSTS:64932

A004T30 (e-PCR)
- UniSTS:72110

RH91501 (e-PCR)
- UniSTS:88496

WI-18922 (e-PCR)
- UniSTS:62388

G60181 (e-PCR)
- UniSTS:137440

D3S2384 (e-PCR), detects polymorphism
- UniSTS:55294

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	EXP Inferred from Experiment more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	TAS Traceable Author Statement more info	PubMed
enables membrane scission GTPase motor activity	IEA Inferred from Electronic Annotation more info
enables myosin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Rho protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in Rho protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Rho protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in Rho protein signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in Roundabout signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in Wnt signaling pathway, planar cell polarity pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
involved_in alpha-beta T cell lineage commitment	IEA Inferred from Electronic Annotation more info
involved_in androgen receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info
involved_in aortic valve formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in apical junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apolipoprotein A-I-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in beta selection	IEA Inferred from Electronic Annotation more info
involved_in bone trabecula morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to chemokine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to cytokine stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in cerebral cortex cell migration	IEA Inferred from Electronic Annotation more info
involved_in cleavage furrow formation	IDA Inferred from Direct Assay more info	PubMed
involved_in cytoplasmic microtubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endothelial cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within endothelial tube lumen extension	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of epithelial cell apical/basal polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in forebrain radial glial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in kidney development	IEA Inferred from Electronic Annotation more info
involved_in mitotic cleavage furrow formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell migration involved in sprouting angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell-substrate adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of intracellular steroid hormone receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of motor neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of oxidative phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of reactive oxygen species biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in neuron migration	IEA Inferred from Electronic Annotation more info
involved_in odontogenesis	IEA Inferred from Electronic Annotation more info
involved_in ossification involved in bone maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of alpha-beta T cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lipase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of lipase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of non-canonical NF-kappaB signal transduction	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of podosome assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of stress fiber assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of stress fiber assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular associated smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of focal adhesion assembly	TAS Traceable Author Statement more info	PubMed
involved_in regulation of microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of modification of postsynaptic actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of modification of postsynaptic actin cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of modification of postsynaptic structure	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of modification of postsynaptic structure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neural precursor cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in regulation of osteoblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of systemic arterial blood pressure by endothelin	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in semaphorin-plexin signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in skeletal muscle satellite cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in skeletal muscle tissue development	IEA Inferred from Electronic Annotation more info
involved_in stress fiber assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in stress fiber assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in substantia nigra development	HEP more info	PubMed
involved_in substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing, spreading of cells	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical junction complex	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell junction	TAS Traceable Author Statement more info
located_in cell periphery	IMP Inferred from Mutant Phenotype more info	PubMed
colocalizes_with cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in endosome	IMP Inferred from Mutant Phenotype more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in ficolin-1-rich granule membrane	TAS Traceable Author Statement more info
located_in focal adhesion	HDA more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info
located_in secretory granule membrane	TAS Traceable Author Statement more info
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transforming protein RhoA

Names: Aplysia ras-related homolog 12; epididymis secretory sperm binding protein; oncogene RHO H12; small GTP binding protein RhoA

NP_001300870.1

EC 3.6.5.2

NP_001300872.1

EC 3.6.5.2

NP_001300873.1

EC 3.6.5.2

NP_001300874.1

EC 3.6.5.2

NP_001300875.1

EC 3.6.5.2

NP_001300876.1

EC 3.6.5.2

NP_001655.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_051308.1 RefSeqGene

Range

5122..57953

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1085

mRNA and Protein(s)

NM_001313941.2 → NP_001300870.1 transforming protein RhoA isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC104452, AC121247, BF966305

Consensus CDS

CCDS2795.1

UniProtKB/Swiss-Prot

P06749, P61586, Q53HM4, Q5U024, Q9UDJ0, Q9UEJ4

UniProtKB/TrEMBL

A0A024R2W1, A0A024R324, Q5JR08

Related

ENSP00000408402.3, ENST00000445425.6

Conserved Domains (1) summary

cd01870
Location:5 → 179

RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC
NM_001313943.2 → NP_001300872.1 transforming protein RhoA isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternate 3' coding exon, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC104452, AC121247, BQ721697

Consensus CDS

CCDS82775.1

UniProtKB/TrEMBL

C9JX21

Related

ENSP00000413587.1, ENST00000422781.6

Conserved Domains (3) summary

smart00174
Location:8 → 146

RHO; Rho (Ras homology) subfamily of Ras-like small GTPases

pfam13900
Location:151 → 182

GVQW; Putative domain of unknown function

cl21455
Location:5 → 138

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001313944.2 → NP_001300873.1 transforming protein RhoA isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses two alternate in-frame splice sites in the 3' coding region, compared to variant 1. The resulting isoform (3) is shorter compared to isoform 1.

Source sequence(s)

AC104452, AC121247, AI269293, AK296654

UniProtKB/TrEMBL

B4DKN9

Conserved Domains (1) summary

cd01870
Location:5 → 159

RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC
NM_001313945.2 → NP_001300874.1 transforming protein RhoA isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 5' region and uses a downstream start codon compared to variant 1. The resulting isoform (4) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AC121247, AI269293, AK307220, EL952052

UniProtKB/TrEMBL

Q9BVT0

Conserved Domains (1) summary

cl38936
Location:1 → 98

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001313946.2 → NP_001300875.1 transforming protein RhoA isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks two alternate in-frame exons in the 3' coding region compared to variant 1.The resulting isoform (5) is shorter compared to isoform 1.

Source sequence(s)

AC104452, AC121247, AW403464

Consensus CDS

CCDS93276.1

UniProtKB/TrEMBL

A0A0B6XK12, A0A7I2YQV1

Related

ENSP00000504603.1, ENST00000676712.2

Conserved Domains (1) summary

cl38936
Location:5 → 95

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001313947.2 → NP_001300876.1 transforming protein RhoA isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks an alternate exon in the 5' coding region which results in a frameshift, compared to variant 1. The resulting isoform (6) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC104452, AC121247, BU509012

Consensus CDS

CCDS82774.1

UniProtKB/TrEMBL

C9JRM1

Related

ENSP00000394483.2, ENST00000454011.7

Conserved Domains (1) summary

cl38936
Location:5 → 52

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001664.4 → NP_001655.1 transforming protein RhoA isoform 1 precursor

See identical proteins and their annotated locations for NP_001655.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1). Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK130066, BC000946

Consensus CDS

CCDS2795.1

UniProtKB/Swiss-Prot

P06749, P61586, Q53HM4, Q5U024, Q9UDJ0, Q9UEJ4

UniProtKB/TrEMBL

A0A024R2W1, A0A024R324, Q5JR08

Related

ENSP00000400175.1, ENST00000418115.6

Conserved Domains (1) summary

cd01870
Location:5 → 179

RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC