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    SINAT2 uncharacterized protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824973, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SINAT2
    Official Full Name
    uncharacterized protein
    Primary source
    TAIR:AT3G58040
    Locus tag
    AT3G58040
    See related
    Araport:AT3G58040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    seven in absentia of Arabidopsis 2
    Summary
    Encodes a RING finger domain containing protein that interacts with AtRAP2.2.
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    Genomic context

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    See SINAT2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    3
    Sequence:
    Chromosome: 3; NC_003074.8 (21488433..21491518)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene tRNA-Ser Neighboring gene uncharacterized protein Neighboring gene Cation efflux family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcription factor RAP2.2 and its interacting partner SINAT2: stable elements in the carotenogenesis of Arabidopsis leaves. Welsch R, et al. Plant Physiol, 2007 Nov. PMID 17873090, Free PMC Article
    2. 14-3-3 proteins contribute to autophagy by modulating SINAT-mediated degradation of ATG13. Qi H, et al. Plant Cell, 2022 Nov 29. PMID 36053201, Free PMC Article
    3. SINAT E3 ligases regulate the stability of the ESCRT component FREE1 in response to iron deficiency in plants. Xiao Z, et al. J Integr Plant Biol, 2020 Sep. PMID 32786047
    4. The tumor necrosis factor receptor-associated factor (TRAF)-like family protein SEVEN IN ABSENTIA 2 (SINA2) promotes drought tolerance in an ABA-dependent manner in Arabidopsis. Bao Y, et al. New Phytol, 2014 Apr. PMID 24350984
    5. TRAF Family Proteins Regulate Autophagy Dynamics by Modulating AUTOPHAGY PROTEIN6 Stability in Arabidopsis. Qi H, et al. Plant Cell, 2017 Apr. PMID 28351989, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The action of SINAT2 may explain the recalcitrance of AtRAP2.2 protein levels to change by altering AtRAP2.2 transcription.
      Title: Transcription factor RAP2.2 and its interacting partner SINAT2: stable elements in the carotenogenesis of Arabidopsis leaves.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_115666.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein ubiquitination IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in regulation of autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_001326739.1
    • seven in absentia of Arabidopsis 2
    NP_001326740.1
    • seven in absentia of Arabidopsis 2
    NP_191363.1
    • seven in absentia of Arabidopsis 2 (SINAT2); FUNCTIONS IN: protein binding; INVOLVED IN: multicellular organismal development, protein ubiquitination, ubiquitin-dependent protein catabolic process; LOCATED IN: nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: TRAF-like (InterPro:IPR008974), Seven-in-absentia protein, TRAF-like domain (InterPro:IPR018121), Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, SIAH-type (InterPro:IPR013010), Seven In Absentia Homolog-type (InterPro:IPR013323), Seven-in-absentia protein, sina (InterPro:IPR004162), TRAF-type (InterPro:IPR013322); BEST Arabidopsis thaliana protein match is: Protein with RING/U-box and TRAF-like domains (TAIR:AT2G41980.1); Has 1862 Blast hits to 1847 proteins in 701 species: Archae - 0; Bacteria - 0; Metazoa - 1276; Fungi - 4; Plants - 482; Viruses - 0; Other Eukaryotes - 100 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      21488433..21491518
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001339902.1 → NP_001326740.1  uncharacterized protein AT3G58040 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M2P4
      Conserved Domains (2) summary
      cd16571
      Location:58 → 96
      RING-HC_SIAHs; RING finger, HC subclass, found in Drosophila melanogaster protein Seven-in-Absentia (sina) and its homologs
      cl19105
      Location:102 → 215
      Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...

    2. NM_001339903.1 → NP_001326739.1  uncharacterized protein AT3G58040 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WNH5, Q1ECQ0, Q9M2P4
      UniProtKB/TrEMBL
      A0A178VHN9, A0A5S9XLU1
      Conserved Domains (2) summary
      cd16571
      Location:58 → 96
      RING-HC_SIAHs; RING finger, HC subclass, found in Drosophila melanogaster protein Seven-in-Absentia (sina) and its homologs
      pfam03145
      Location:102 → 301
      Sina; Seven in absentia protein family

    3. NM_115666.2 → NP_191363.1  uncharacterized protein AT3G58040 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191363.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WNH5, Q1ECQ0, Q9M2P4
      UniProtKB/TrEMBL
      A0A178VHN9, A0A5S9XLU1
      Conserved Domains (2) summary
      cd16571
      Location:58 → 96
      RING-HC_SIAHs; RING finger, HC subclass, found in Drosophila melanogaster protein Seven-in-Absentia (sina) and its homologs
      pfam03145
      Location:102 → 301
      Sina; Seven in absentia protein family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M2P4.1

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