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    PRN pirin [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825091, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PRN
    Official Full Name
    pirin
    Primary source
    TAIR:AT3G59220
    Locus tag
    AT3G59220
    See related
    Araport:AT3G59220
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATPIRIN1; pirin; PRN1
    Summary
    encodes a cupin-domain containing protein that is similar to pirins which interact with a CCAAT box binding transcription factor. The protein interacts with GPA1 (G protein alpha-subunit) in vitro. Mutants in the gene are affected in germination and early seedling development.
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    Genomic context

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    See PRN in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    6
    Sequence:
    Chromosome: 3; NC_003074.8 (21893812..21895789)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene F-box/RNI-like superfamily protein Neighboring gene F-box/RNI-like superfamily protein Neighboring gene RNI-like superfamily protein Neighboring gene RNI-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pirin1 (PRN1) is a multifunctional protein that regulates quercetin, and impacts specific light and UV responses in the seed-to-seedling transition of Arabidopsis thaliana. Orozco-Nunnelly DA, et al. PLoS One, 2014. PMID 24705271, Free PMC Article
    2. Susceptibility of intact germinating Arabidopsis thaliana to human fungal pathogens Cryptococcus neoformans and C. gattii. Warpeha KM, et al. Appl Environ Microbiol, 2013 May. PMID 23435895, Free PMC Article
    3. The Arabidopsis cupin domain protein AtPirin1 interacts with the G protein alpha-subunit GPA1 and regulates seed germination and early seedling development. Lapik YR, et al. Plant Cell, 2003 Jul. PMID 12837948, Free PMC Article
    4. The GCR1, GPA1, PRN1, NF-Y signal chain mediates both blue light and abscisic acid responses in Arabidopsis. Warpeha KM, et al. Plant Physiol, 2007 Apr. PMID 17322342, Free PMC Article
    5. Proteomic profiling of tandem affinity purified 14-3-3 protein complexes in Arabidopsis thaliana. Chang IF, et al. Proteomics, 2009 Jun. PMID 19452453, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PRN1 may play a critical role in cellular quercetin levels and influence light- or hormonal-directed early development.
      Title: Pirin1 (PRN1) is a multifunctional protein that regulates quercetin, and impacts specific light and UV responses in the seed-to-seedling transition of Arabidopsis thaliana.
    2. Arabidopsis mutants of the PRN1 gene, which is involved in abiotic and biotic signaling affecting phenylalanine-derived flavonoids, showed altered susceptibility to cryptoccocal infections, suggesting roles for this pathway in cryptococcal defense.
      Title: Susceptibility of intact germinating Arabidopsis thaliana to human fungal pathogens Cryptococcus neoformans and C. gattii.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_115784.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in blue light signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to low fluence blue light stimulus by blue low-fluence system NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    pirin
    NP_191481.1
    • pirin (PRN); CONTAINS InterPro DOMAIN/s: Pirin, C-terminal (InterPro:IPR008778), Pirin (InterPro:IPR012093), Cupin, RmlC-type (InterPro:IPR011051), Pirin, N-terminal (InterPro:IPR003829); BEST Arabidopsis thaliana protein match is: RmlC-like cupins superfamily protein (TAIR:AT2G43120.1); Has 7400 Blast hits to 7400 proteins in 1466 species: Archae - 64; Bacteria - 4668; Metazoa - 71; Fungi - 217; Plants - 125; Viruses - 0; Other Eukaryotes - 2255 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      21893812..21895789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115784.3 → NP_191481.1  pirin [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191481.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LX49
      UniProtKB/TrEMBL
      A0A178VHE5, A0A654FJ54, Q147N7
      Conserved Domains (1) summary
      COG1741
      Location:37 → 279
      YhaK; Redox-sensitive bicupin YhaK, pirin superfamily [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LX49.1

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