MID1 midline 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MID1provided by HGNC
Official Full Name: midline 1provided by HGNC
Primary source: HGNC:HGNC:7095
See related: Ensembl:ENSG00000101871 MIM:300552; AllianceGenome:HGNC:7095
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: OS; FXY; OSX; GBBB; OGS1; XPRF; BBBG1; GBBB1; MIDIN; RNF59; ZNFXY; TRIM18
Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse. Alternative promoter use, alternative splicing and alternative polyadenylation result in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]
Expression: Ubiquitous expression in prostate (RPKM 2.5), urinary bladder (RPKM 2.3) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xp22.2

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (10445310..10833683, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (10027869..10416213, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (10413350..10851802, complement)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mid1 promotes synovitis in rheumatoid arthritis via ubiquitin-dependent post-translational modification.
Title: Mid1 promotes synovitis in rheumatoid arthritis via ubiquitin-dependent post-translational modification.
Erdr1 Drives Macrophage Programming via Dynamic Interplay with YAP1 and Mid1.
Title: Erdr1 Drives Macrophage Programming via Dynamic Interplay with YAP1 and Mid1.
Absence of the RING domain in MID1 results in patterning defects in the developing human brain.
Title: Absence of the RING domain in MID1 results in patterning defects in the developing human brain.
Opitz GBBB syndrome with total anomalous pulmonary venous connection: A new MID1 gene variant.
Title: Opitz GBBB syndrome with total anomalous pulmonary venous connection: A new MID1 gene variant.
Irradiated lung cancer cell-derived exosomes modulate macrophage polarization by inhibiting MID1 via miR-4655-5p.
Title: Irradiated lung cancer cell-derived exosomes modulate macrophage polarization by inhibiting MID1 via miR-4655-5p.
B-box1 Domain of MID1 Interacts with the Ube2D1 E2 Enzyme Differently Than RING E3 Ligases.
Title: B-box1 Domain of MID1 Interacts with the Ube2D1 E2 Enzyme Differently Than RING E3 Ligases.
The role of anillin/Mid1p during medial division and cytokinesis: from fission yeast to cancer cells.
Title: The role of anillin/Mid1p during medial division and cytokinesis: from fission yeast to cancer cells.
TRIM18 is a critical regulator of viral myocarditis and organ inflammation.
Title: TRIM18 is a critical regulator of viral myocarditis and organ inflammation.
Ubiquitin E3 ligase MID1 inhibits the innate immune response by ubiquitinating IRF3.
Title: Ubiquitin E3 ligase MID1 inhibits the innate immune response by ubiquitinating IRF3.
Hydrothorax in fetal cases of Opitz G/BBB diagnosis: Extending the phenotype?
Title: Hydrothorax in fetal cases of Opitz G/BBB diagnosis: Extending the phenotype?

Submit: New GeneRIF Correction See all GeneRIFs (56)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
X-linked Opitz G/BBB syndrome MedGen: C2936904 OMIM: 300000 GeneReviews: MID1-Related Opitz G/BBB Syndrome	not available

Copy number response

Description
Copy number response Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2021-08-23) ClinGen Genome Curation PagePubMed Triplosensitivity No evidence available (Last evaluated 2021-08-23) ClinGen Genome Curation Page

EBI GWAS Catalog

Description
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-84226 (e-PCR)
- UniSTS:104714

A004G38 (e-PCR)
- UniSTS:36108

STS-AA026423 (e-PCR)
- UniSTS:15122

SHGC-83251 (e-PCR)
- UniSTS:101138

MID1__6312 (e-PCR)
- UniSTS:468522

RH18198 (e-PCR)
- UniSTS:7239

PMC15848P1 (e-PCR)
- UniSTS:271436

RH120215 (e-PCR)
- UniSTS:133208

AF003639 (e-PCR)
- UniSTS:94578

HSC1ZH102 (e-PCR)
- UniSTS:41076

RH65878 (e-PCR)
- UniSTS:76155

AF003649 (e-PCR)
- UniSTS:94588

AF003650 (e-PCR)
- UniSTS:94589

AF003652 (e-PCR)
- UniSTS:94591

RH65583 (e-PCR)
- UniSTS:75656

AF003662 (e-PCR)
- UniSTS:94601

AF003663 (e-PCR)
- UniSTS:94602

AF003670 (e-PCR)
- UniSTS:94609

AF003673 (e-PCR)
- UniSTS:94612

AF003674 (e-PCR)
- UniSTS:94613

DXS1438 (e-PCR)
- UniSTS:99221

AF003675 (e-PCR)
- UniSTS:94614

AF003676 (e-PCR)
- UniSTS:94615

AF003677 (e-PCR)
- UniSTS:94616

RH67856 (e-PCR)
- UniSTS:6809

AF003682 (e-PCR)
- UniSTS:94621

AF003683 (e-PCR)
- UniSTS:94622

DXS7916 (e-PCR)
- UniSTS:99230

AF003684 (e-PCR)
- UniSTS:94623

AF003686 (e-PCR)
- UniSTS:94625

AF003689 (e-PCR)
- UniSTS:94628

DXS7713 (e-PCR)
- UniSTS:81071

NoName (e-PCR)
- UniSTS:99542

RH99148 (e-PCR)
- UniSTS:85976

SHGC-36657 (e-PCR)
- UniSTS:44777

MID1 (e-PCR)
- UniSTS:498175

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables microtubule binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphoprotein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in microtubule cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of microtubule depolymerization	IEA Inferred from Electronic Annotation more info
involved_in pattern specification process	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of stress-activated MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to microtubule	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info
located_in centriolar satellite	IDA Inferred from Direct Assay more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with cytoplasmic microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
part_of microtubule associated complex	TAS Traceable Author Statement more info	PubMed
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase Midline-1

Names: Opitz/BBB syndrome; RING finger protein 59; RING finger protein Midline-1; RING-type E3 ubiquitin transferase Midline-1; midline 1 RING finger protein; putative transcription factor XPRF; tripartite motif protein TRIM18; tripartite motif-containing protein 18; zinc finger on X and Y, mouse, homolog of

NP_000372.1

EC 2.3.2.27

NP_001092094.1

EC 2.3.2.27

NP_001180206.1

EC 2.3.2.27

NP_001180207.1

EC 2.3.2.27

NP_001180208.1

EC 2.3.2.27

NP_001180209.1

EC 2.3.2.27

NP_001334662.1

EC 2.3.2.27

NP_150631.1

EC 2.3.2.27

NP_150632.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008197.2 RefSeqGene

Range

218106..393135

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000381.4 → NP_000372.1 E3 ubiquitin-protein ligase Midline-1 isoform 1

See identical proteins and their annotated locations for NP_000372.1

Status: REVIEWED

Description

Transcript Variant: This variant (1, also known as alpha) is the longest transcript. Variants 1-4 and variant 10 encode the same isoform (1).

Source sequence(s)

BC053626, DC309977, EF217426

Consensus CDS

CCDS14138.1

UniProtKB/Swiss-Prot

B2RCG2, O15344, O75361, Q9BZX5

UniProtKB/TrEMBL

A8K5A0

Related

ENSP00000312678.4, ENST00000317552.9

Conserved Domains (7) summary

smart00502
Location:219 → 344

BBC; B-Box C-terminal domain

cd00063
Location:381 → 481

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd12892
Location:485 → 661

SPRY_PRY_TRIM18; PRY/SPRY domain of TRIM18/MID1, also known as FXY or RNF59

cd16753
Location:8 → 61

RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins

cd19822
Location:168 → 214

Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

pfam18568
Location:323 → 374

COS; TRIM C-terminal subgroup One Signature domain
NM_001098624.2 → NP_001092094.1 E3 ubiquitin-protein ligase Midline-1 isoform 1

See identical proteins and their annotated locations for NP_001092094.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) has an alternate 5' UTR exon, as compared to variant 1. Variants 1-4 and variant 10 encode the same isoform (1).

Source sequence(s)

BC053626, DC369426, EF217426

Consensus CDS

CCDS14138.1

UniProtKB/Swiss-Prot

B2RCG2, O15344, O75361, Q9BZX5

UniProtKB/TrEMBL

A8K5A0

Related

ENSP00000414521.2, ENST00000453318.6

Conserved Domains (7) summary

smart00502
Location:219 → 344

BBC; B-Box C-terminal domain

cd00063
Location:381 → 481

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd12892
Location:485 → 661

SPRY_PRY_TRIM18; PRY/SPRY domain of TRIM18/MID1, also known as FXY or RNF59

cd16753
Location:8 → 61

RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins

cd19822
Location:168 → 214

Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

pfam18568
Location:323 → 374

COS; TRIM C-terminal subgroup One Signature domain
NM_001193277.1 → NP_001180206.1 E3 ubiquitin-protein ligase Midline-1 isoform 1

See identical proteins and their annotated locations for NP_001180206.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an alternate 5' UTR exon, as compared to variant 1. Variants 1-4 and variant 10 encode the same isoform (1).

Source sequence(s)

AF035360, DA435613, EF217426

Consensus CDS

CCDS14138.1

UniProtKB/Swiss-Prot

B2RCG2, O15344, O75361, Q9BZX5

UniProtKB/TrEMBL

A8K5A0

Related

ENSP00000370156.1, ENST00000380779.5

Conserved Domains (7) summary

smart00502
Location:219 → 344

BBC; B-Box C-terminal domain

cd00063
Location:381 → 481

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd12892
Location:485 → 661

SPRY_PRY_TRIM18; PRY/SPRY domain of TRIM18/MID1, also known as FXY or RNF59

cd16753
Location:8 → 61

RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins

cd19822
Location:168 → 214

Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

pfam18568
Location:323 → 374

COS; TRIM C-terminal subgroup One Signature domain
NM_001193278.1 → NP_001180207.1 E3 ubiquitin-protein ligase Midline-1 isoform 3

See identical proteins and their annotated locations for NP_001180207.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) has an additional in-frame exon in the CDS and also lacks several 3' exons but has an alternate 3' segment, as compared to variant 1. The resulting isoform (3) has an additional segment in the middle region and has a shorter and different C-terminus, as compared to isoform 1.

Source sequence(s)

AF035360, AI371111, AY539994

Consensus CDS

CCDS75952.1

UniProtKB/TrEMBL

A0A087X255

Related

ENSP00000484712.1, ENST00000616003.5

Conserved Domains (3) summary

smart00336
Location:171 → 212

BBOX; B-Box-type zinc finger

cd00162
Location:9 → 63

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cl23765
Location:303 → 395

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
NM_001193279.1 → NP_001180208.1 E3 ubiquitin-protein ligase Midline-1 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks several 3' exons but has an alternate 3' segment, as compared to variant 1. The resulting isoform (4) has a shorter and different C-terminus, as compared to isoform 1.

Source sequence(s)

AF035360, AI371111, AY540022

Consensus CDS

CCDS94548.1

UniProtKB/TrEMBL

A0A8I5KPE0, C9J453

Related

ENSP00000508734.1, ENST00000687008.1

Conserved Domains (3) summary

smart00336
Location:171 → 212

BBOX; B-Box-type zinc finger

cd00162
Location:9 → 63

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cl23765
Location:219 → 344

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
NM_001193280.1 → NP_001180209.1 E3 ubiquitin-protein ligase Midline-1 isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (8) has an alternate splice site in the CDS and also lacks several 3' exons but has an alternate 3' segment, as compared to variant 1. The resulting isoform (5) lacks an internal segment in the N-terminal region and has a shorter and different C-terminus, as compared to isoform 1.

Source sequence(s)

AF035360, AI371111, AY540023

UniProtKB/TrEMBL

B7Z5K6

Conserved Domains (3) summary

smart00336
Location:114 → 152

BBOX; B-Box-type zinc finger

cd00162
Location:9 → 63

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cl23765
Location:182 → 306

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
NM_001347733.2 → NP_001334662.1 E3 ubiquitin-protein ligase Midline-1 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (10) has an alternate 5' UTR exon, as compared to variant 1. Variants 1-4 and variant 10 encode the same isoform (1). This variant represents use of an alternate long terminal repeat (LTR) promoter and exon sequence, and results in placenta expression. (PMID: 12411602)

Source sequence(s)

AC008008, AC117406

Consensus CDS

CCDS14138.1

UniProtKB/Swiss-Prot

B2RCG2, O15344, O75361, Q9BZX5

UniProtKB/TrEMBL

A8K5A0

Related

ENSP00000370157.1, ENST00000380780.5

Conserved Domains (7) summary

smart00502
Location:219 → 344

BBC; B-Box C-terminal domain

cd00063
Location:381 → 481

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd12892
Location:485 → 661

SPRY_PRY_TRIM18; PRY/SPRY domain of TRIM18/MID1, also known as FXY or RNF59

cd16753
Location:8 → 61

RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins

cd19822
Location:168 → 214

Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

pfam18568
Location:323 → 374

COS; TRIM C-terminal subgroup One Signature domain
NM_033289.2 → NP_150631.1 E3 ubiquitin-protein ligase Midline-1 isoform 2

See identical proteins and their annotated locations for NP_150631.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) has an alternate splice site in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal segment in the N-terminal region, as compared to the isoform 1.

Source sequence(s)

AK226104, DC309977, EF217426

Consensus CDS

CCDS94549.1

UniProtKB/TrEMBL

A0A8I5KR14, B4DLX8

Related

ENSP00000509730.1, ENST00000690004.1

Conserved Domains (6) summary

smart00502
Location:182 → 306

BBC; B-Box C-terminal domain

cd00063
Location:343 → 443

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd12892
Location:447 → 623

SPRY_PRY_TRIM18; PRY/SPRY domain of TRIM18/MID1, also known as FXY or RNF59

cd16753
Location:8 → 61

RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

pfam18568
Location:285 → 336

COS; TRIM C-terminal subgroup One Signature domain
NM_033290.4 → NP_150632.1 E3 ubiquitin-protein ligase Midline-1 isoform 1

See identical proteins and their annotated locations for NP_150632.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) has an alternate 5' UTR exon, as compared to variant 1. Variants 1-4 and variant 10 encode the same isoform (1). Expression was found to be adipose specific.

Source sequence(s)

AF041210, DA856308, EF217426

Consensus CDS

CCDS14138.1

UniProtKB/Swiss-Prot

B2RCG2, O15344, O75361, Q9BZX5

UniProtKB/TrEMBL

A8K5A0

Related

ENSP00000370164.1, ENST00000380787.5

Conserved Domains (7) summary

smart00502
Location:219 → 344

BBC; B-Box C-terminal domain

cd00063
Location:381 → 481

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd12892
Location:485 → 661

SPRY_PRY_TRIM18; PRY/SPRY domain of TRIM18/MID1, also known as FXY or RNF59

cd16753
Location:8 → 61

RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins

cd19822
Location:168 → 214

Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

pfam18568
Location:323 → 374

COS; TRIM C-terminal subgroup One Signature domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000023.11 Reference GRCh38.p14 Primary Assembly

Range

10445310..10833683 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060947.1 Alternate T2T-CHM13v2.0

Range

10027869..10416213 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001193281.1: Suppressed sequence

Description

NM_001193281.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
NM_033291.1: Suppressed sequence

Description

NM_033291.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.