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    ZNF684 zinc finger protein 684 [ Homo sapiens (human) ]

    Gene ID: 127396, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZNF684provided by HGNC
    Official Full Name
    zinc finger protein 684provided by HGNC
    Primary source
    HGNC:HGNC:28418
    See related
    Ensembl:ENSG00000117010 AllianceGenome:HGNC:28418
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within innate immune response and negative regulation of single stranded viral RNA replication via double stranded DNA intermediate. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney (RPKM 1.9), liver (RPKM 1.8) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ZNF684 in Genome Data Viewer
    Location:
    1p34.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (40531637..40548167)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (40400805..40417330)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40997309..41013839)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 846 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 847 Neighboring gene exonuclease 5 Neighboring gene uncharacterized LOC124904149 Neighboring gene Sharpr-MPRA regulatory region 98 Neighboring gene eukaryotic translation initiation factor 2 subunit gamma pseudogene Neighboring gene uncharacterized LOC105378673

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC27466

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 684
    Names
    hypothetical protein MGC27466

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152373.4NP_689586.3  zinc finger protein 684

      See identical proteins and their annotated locations for NP_689586.3

      Status: VALIDATED

      Source sequence(s)
      AK094072, BC111463, BG116229
      Consensus CDS
      CCDS454.1
      UniProtKB/Swiss-Prot
      Q2NKY4, Q5T5D7
      Related
      ENSP00000361784.3, ENST00000372699.8
      Conserved Domains (6) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
      COG5048
      Location:185345
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:301321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:187209
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:847
      KRAB; KRAB box
      pfam13465
      Location:341366
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      40531637..40548167
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      40400805..40417330
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)