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    I-2 phosphoprotein phosphatase inhibitor [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835296, updated on 18-Sep-2024

    Summary

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    Official Symbol
    I-2
    Official Full Name
    phosphoprotein phosphatase inhibitor
    Primary source
    TAIR:AT5G52200
    Locus tag
    AT5G52200
    See related
    Araport:AT5G52200
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtI-2; F17P19.10; F17P19_10; inhibitor-2
    Summary
    Encodes an inhibitor of protein phosphatase one (PP1).
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    Genomic context

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    See I-2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (21202549..21204816, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene homeodomain GLABROUS 7 Neighboring gene transmembrane protein 161AB protein Neighboring gene Sugar isomerase (SIS) family protein Neighboring gene GTP-binding protein 1 Neighboring gene ncRNA Neighboring gene chromosome transmission fidelity-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Type One Protein Phosphatase 1 and Its Regulatory Protein Inhibitor 2 Negatively Regulate ABA Signaling. Hou YJ, et al. PLoS Genet, 2016 Mar. PMID 26943172, Free PMC Article
    2. Identification and characterization of AtI-2, an Arabidopsis homologue of an ancient protein phosphatase 1 (PP1) regulatory subunit. Templeton GW, et al. Biochem J, 2011 Apr 1. PMID 21222654
    3. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
    4. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TOPP1 and AtI-2 are negative regulators of ABA signaling.
      Title: Type One Protein Phosphatase 1 and Its Regulatory Protein Inhibitor 2 Negatively Regulate ABA Signaling.
    2. AtI-2 inhibits the phosphatase activity of all PP1 isoforms of Arabidopsis. [AtI-2]
      Title: Identification and characterization of AtI-2, an Arabidopsis homologue of an ancient protein phosphatase 1 (PP1) regulatory subunit.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001344988.1
    NM_124599.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein phosphatase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    phosphoprotein phosphatase inhibitor
    NP_001318787.1
    • phosphoprotein phosphatase inhibitors; FUNCTIONS IN: phosphoprotein phosphatase inhibitor activity; INVOLVED IN: regulation of signal transduction, regulation of phosphoprotein phosphatase activity; LOCATED IN: endomembrane system; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein phosphatase inhibitor 2 (IPP-2) (InterPro:IPR007062).
    NP_568768.1
    • phosphoprotein phosphatase inhibitors; FUNCTIONS IN: phosphoprotein phosphatase inhibitor activity; INVOLVED IN: regulation of signal transduction, regulation of phosphoprotein phosphatase activity; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein phosphatase inhibitor 2 (IPP-2) (InterPro:IPR007062); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      21202549..21204816 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001344989.1 → NP_001332547.1  phosphoprotein phosphatase inhibitor [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4KEU1

    2. NM_001344988.1 → NP_001318787.1  phosphoprotein phosphatase inhibitor [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4KEU1

    3. NM_124599.5 → NP_568768.1  phosphoprotein phosphatase inhibitor [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568768.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LTK0
      UniProtKB/TrEMBL
      A0A178UH99, A0A5S9YD95
      Conserved Domains (1) summary
      pfam04979
      Location:9 → 141
      IPP-2; Protein phosphatase inhibitor 2 (IPP-2)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LTK0.1

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