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    USP UDP-sugar pyrophosphorylase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835333, updated on 14-Nov-2024

    Summary

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    Official Symbol
    USP
    Official Full Name
    UDP-sugar pyrophosphorylase
    Primary source
    TAIR:AT5G52560
    Locus tag
    AT5G52560
    See related
    Araport:AT5G52560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATUSP; F6N7.4; F6N7_4; UDP-sugar pyrophosphorylase
    Summary
    Encodes a protein with UTP:sugar 1-phosphate uridylyltransferase activity, which has been shown to use a wide range of substrates including glucose-1-P, galactose-1-P, xylose-1-P, arabinose-1-P and glucuronate-1-P. The enzyme was shown to require Mg2+ or Mn2+ for activity. Mutations in USP can lead to a complete loss of male fertility.
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    Genomic context

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    See USP in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    18
    Sequence:
    Chromosome: 5; NC_003076.8 (21330608..21334811)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene stress response NST1-like protein Neighboring gene beta-carotene hydroxylase 2 Neighboring gene RabGAP/TBC domain-containing protein Neighboring gene myb domain protein 82

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of the Arabidopsis universal stress protein AtUSP with an antifungal activity. Park SC, et al. Biochem Biophys Res Commun, 2017 May 13. PMID 28347820
    2. UDP-sugar pyrophosphorylase controls the activity of proceeding sugar-1-kinases enzymes. Geserick C, et al. Plant Signal Behav, 2013 Sep. PMID 23857351, Free PMC Article
    3. UDP-sugar pyrophosphorylase is essential for arabinose and xylose recycling, and is required during vegetative and reproductive growth in Arabidopsis. Geserick C, et al. Plant J, 2013 Apr. PMID 23373795, Free PMC Article
    4. Arabidopsis UDP-sugar pyrophosphorylase: evidence for two isoforms. Gronwald JW, et al. Plant Physiol Biochem, 2008 Dec. PMID 18768324
    5. Properties and physiological functions of UDP-sugar pyrophosphorylase in Arabidopsis. Kotake T, et al. Biosci Biotechnol Biochem, 2007 Mar. PMID 17341835

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that Arabidopsis AtUSP plays a critical role in the plant tolerance to diverse pathogenic infections. The potent antifungal action, which is a new function of AtUSP, was attributed to fungal reactive oxygen species (ROS) generation and mitochondrial potential alteration.
      Title: Functional characterization of the Arabidopsis universal stress protein AtUSP with an antifungal activity.
    2. Gene silencing of USP by miRNA cause a concomitant reduction of USP and of glucuronokinase activity.
      Title: UDP-sugar pyrophosphorylase controls the activity of proceeding sugar-1-kinases enzymes.
    3. AtUSP functions as a UDP-sugar pyrophosphorylase in the salvage pathway, and that the generation of UDP-sugars from monosaccharide 1-phosphates catalyzed by AtUSP is essential for pollen development in Arabidopsis.[AtUSP]
      Title: Properties and physiological functions of UDP-sugar pyrophosphorylase in Arabidopsis.
    4. The substrate specificity and kinetic properties of UDP-sugar pyrophosphorylase in Arabidopsis are reported.
      Title: Characterization and expression of Arabidopsis UDP-sugar pyrophosphorylase.
    5. AtUSP (At5g52560) has a critical role in pollen development.
      Title: UDP-sugar pyrophosphorylase is essential for pollen development in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_124635.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables UTP-monosaccharide-1-phosphate uridylyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables UTP:arabinose-1-phosphate uridylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UTP:galactose-1-phosphate uridylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UTP:glucose-1-phosphate uridylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UTP:xylose-1-phosphate uridylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glucuronate-1-phosphate uridylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within UDP-D-galactose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within UDP-L-arabinose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within UDP-alpha-D-glucose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within UDP-glucuronate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within nucleotide-sugar biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pollen tube IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UDP-sugar pyrophosphorylase
    NP_568775.1
    • UDP-sugar pyrophosphorylase (USP); FUNCTIONS IN: in 6 functions; INVOLVED IN: in 6 processes; LOCATED IN: endomembrane system; EXPRESSED IN: 30 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: UTP--glucose-1-phosphate uridylyltransferase (InterPro:IPR002618); BEST Arabidopsis thaliana protein match is: N-acetylglucosamine-1-phosphate uridylyltransferase 1 (TAIR:AT1G31070.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      21330608..21334811
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124635.4 → NP_568775.1  UDP-sugar pyrophosphorylase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568775.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C5I1, Q9LTG1
      UniProtKB/TrEMBL
      A0A178UND3
      Conserved Domains (1) summary
      PLN02830
      Location:1 → 613
      PLN02830; UDP-sugar pyrophosphorylase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C5I1.1

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