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    ZNF385B zinc finger protein 385B [ Homo sapiens (human) ]

    Gene ID: 151126, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZNF385Bprovided by HGNC
    Official Full Name
    zinc finger protein 385Bprovided by HGNC
    Primary source
    HGNC:HGNC:26332
    See related
    Ensembl:ENSG00000144331 MIM:612344; AllianceGenome:HGNC:26332
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF533
    Summary
    Enables p53 binding activity. Involved in intrinsic apoptotic signaling pathway by p53 class mediator. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung (RPKM 1.7), heart (RPKM 1.4) and 14 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZNF385B in Genome Data Viewer
    Location:
    2q31.2-q31.3
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (179441982..179861612, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (179925075..180344841, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (180306709..180726339, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56714 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56716 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56717 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56718 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56719 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56720 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56724 Neighboring gene SEC14 and spectrin domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:180060941-180061440 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16820 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:180128689-180128852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12153 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12154 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:180133295-180133798 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:180132793-180133294 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16821 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:180142211-180142711 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:180208678-180209877 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:180293959-180294459 Neighboring gene Sharpr-MPRA regulatory region 1228 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:180324663-180325862 Neighboring gene RAD52 pseudogene 1 Neighboring gene uncharacterized LOC101927073 Neighboring gene MPRA-validated peak3953 silencer Neighboring gene TXNL4A pseudogene 1 Neighboring gene microRNA 1258 Neighboring gene small nucleolar RNA SNORA43 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:180871172-180871704 Neighboring gene CWC22 spliceosome associated protein homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (14 hits/1259 screens)

    EBI GWAS Catalog

    Description
    GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
    EBI GWAS Catalog

    Interactions

    General gene information

    Clone Names

    • FLJ25270

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables nucleic acid binding  
    enables p53 binding PubMed 
    enables zinc ion binding  
    Component Evidence Code Pubs
    is_active_in nucleus  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    zinc finger protein 385B
    Names
    zinc finger protein 533

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113397.2 → NP_001106868.1  zinc finger protein 385B isoform 2

      See identical proteins and their annotated locations for NP_001106868.1

      Status: VALIDATED

      Source sequence(s)
      AC062033, AK096822, BC033042, BC092423
      Consensus CDS
      CCDS46463.1
      UniProtKB/Swiss-Prot
      Q49A04, Q569K4, Q6ZMZ7, Q8IY01, Q8N8H2, Q96DK4
      Related
      ENSP00000386379.1, ENST00000409343.5
      Conserved Domains (2) summary
      sd00020
      Location:211 → 273
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:273 → 296
      zf-met; Zinc-finger of C2H2 type
    2. NM_001113398.3 → NP_001106869.1  zinc finger protein 385B isoform 3

      See identical proteins and their annotated locations for NP_001106869.1

      Status: VALIDATED

      Source sequence(s)
      AK057999, BC033042, BC092423
      Consensus CDS
      CCDS46464.1
      UniProtKB/Swiss-Prot
      Q569K4
      Related
      ENSP00000338225.5, ENST00000336917.9
      Conserved Domains (2) summary
      sd00020
      Location:185 → 247
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:246 → 270
      zf-met; Zinc-finger of C2H2 type
    3. NM_001282725.3 → NP_001269654.1  zinc finger protein 385B isoform 3

      See identical proteins and their annotated locations for NP_001269654.1

      Status: VALIDATED

      Source sequence(s)
      BC033042, BC038422, BC048123, BC092423
      Consensus CDS
      CCDS46464.1
      UniProtKB/Swiss-Prot
      Q569K4
      Related
      ENSP00000386507.1, ENST00000409692.5
      Conserved Domains (2) summary
      sd00020
      Location:185 → 247
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:246 → 270
      zf-met; Zinc-finger of C2H2 type
    4. NM_001352808.2 → NP_001339737.1  zinc finger protein 385B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC068042, AC092642, AC093604, BC092423
      Consensus CDS
      CCDS33339.2
      UniProtKB/Swiss-Prot
      Q49A04, Q569K4, Q6ZMZ7, Q8IY01, Q8N8H2, Q96DK4
      UniProtKB/TrEMBL
      A0A2U3TZT0
      Conserved Domains (3) summary
      smart00451
      Location:50 → 80
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:302 → 364
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:363 → 387
      zf-met; Zinc-finger of C2H2 type
    5. NM_001352809.2 → NP_001339738.1  zinc finger protein 385B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC062033, AC068042, AC092642, AC093604, BC092423
      UniProtKB/Swiss-Prot
      Q49A04, Q569K4, Q6ZMZ7, Q8IY01, Q8N8H2, Q96DK4
      Conserved Domains (3) summary
      smart00451
      Location:50 → 80
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:348 → 410
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:409 → 433
      zf-met; Zinc-finger of C2H2 type
    6. NM_001352810.2 → NP_001339739.1  zinc finger protein 385B isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC068042, AC092642, AC093604, BC092423
      UniProtKB/Swiss-Prot
      Q49A04, Q569K4, Q6ZMZ7, Q8IY01, Q8N8H2, Q96DK4
      Conserved Domains (3) summary
      smart00451
      Location:50 → 80
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:329 → 391
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:390 → 414
      zf-met; Zinc-finger of C2H2 type
    7. NM_001352811.2 → NP_001339740.1  zinc finger protein 385B isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC068042, AC092642, AC093604, BC092423
      UniProtKB/Swiss-Prot
      Q49A04, Q569K4, Q6ZMZ7, Q8IY01, Q8N8H2, Q96DK4
      Conserved Domains (3) summary
      smart00451
      Location:50 → 80
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:315 → 377
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:376 → 400
      zf-met; Zinc-finger of C2H2 type
    8. NM_001352812.2 → NP_001339741.1  zinc finger protein 385B isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC062033, AC068042, AC093604, BC092423
      UniProtKB/Swiss-Prot
      Q49A04, Q569K4, Q6ZMZ7, Q8IY01, Q8N8H2, Q96DK4
      Conserved Domains (2) summary
      sd00020
      Location:219 → 281
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:280 → 304
      zf-met; Zinc-finger of C2H2 type
    9. NM_001352813.2 → NP_001339742.1  zinc finger protein 385B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC062033, AC068042, AC093604, BC092423
      Consensus CDS
      CCDS46464.1
      Conserved Domains (2) summary
      sd00020
      Location:185 → 247
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:246 → 270
      zf-met; Zinc-finger of C2H2 type
    10. NM_001352814.2 → NP_001339743.1  zinc finger protein 385B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC062033, AC068042, AC093604, BC092423
      Consensus CDS
      CCDS46464.1
      Conserved Domains (2) summary
      sd00020
      Location:185 → 247
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:246 → 270
      zf-met; Zinc-finger of C2H2 type
    11. NM_001352815.1 → NP_001339744.1  zinc finger protein 385B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC062033, AC068042, AC093604, BC092423
      Consensus CDS
      CCDS46464.1
      Conserved Domains (2) summary
      sd00020
      Location:185 → 247
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:246 → 270
      zf-met; Zinc-finger of C2H2 type
    12. NM_001352816.2 → NP_001339745.1  zinc finger protein 385B isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC068042, AC092642, BC092423
      Conserved Domains (2) summary
      sd00020
      Location:173 → 235
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:234 → 258
      zf-met; Zinc-finger of C2H2 type
    13. NM_001352817.1 → NP_001339746.1  zinc finger protein 385B isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC062033, AC068042, BC092423
      UniProtKB/TrEMBL
      Q53S82
      Conserved Domains (2) summary
      sd00020
      Location:155 → 217
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:216 → 240
      zf-met; Zinc-finger of C2H2 type
    14. NM_152520.6 → NP_689733.4  zinc finger protein 385B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC068042, AC092642, AC093604, BC092423
      Consensus CDS
      CCDS33339.2
      UniProtKB/Swiss-Prot
      Q49A04, Q569K4, Q6ZMZ7, Q8IY01, Q8N8H2, Q96DK4
      UniProtKB/TrEMBL
      A0A2U3TZT0
      Related
      ENSP00000386845.2, ENST00000410066.7
      Conserved Domains (3) summary
      smart00451
      Location:50 → 80
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:302 → 364
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:363 → 387
      zf-met; Zinc-finger of C2H2 type

    RNA

    1. NR_104234.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BC048123
      Related
      ENST00000466398.5
    2. NR_148054.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC068042, AC092642, AC093604, BC092423
    3. NR_148055.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC062033, AC068042, AC093604, BC092423
    4. NR_148056.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC068042, AC092642, AC093604, BC092423
    5. NR_148057.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC068042, AC092642, BC092423
    6. NR_148058.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC068042, AC092642, AC093604, BC092423
    7. NR_148059.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC062033, AC068042, BC092423

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      179441982..179861612 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      179925075..180344841 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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