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    ATP8B4 ATPase phospholipid transporting 8B4 (putative) [ Homo sapiens (human) ]

    Gene ID: 79895, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ATP8B4provided by HGNC
    Official Full Name
    ATPase phospholipid transporting 8B4 (putative)provided by HGNC
    Primary source
    HGNC:HGNC:13536
    See related
    Ensembl:ENSG00000104043 MIM:609123; AllianceGenome:HGNC:13536
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATPIM
    Summary
    This gene encodes a member of the cation transport ATPase (P-type) family and type IV subfamily. The encoded protein is involved in phospholipid transport in the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
    Expression
    Broad expression in bone marrow (RPKM 8.4), placenta (RPKM 2.4) and 14 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ATP8B4 in Genome Data Viewer
    Location:
    15q21.2
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (49858238..50181854, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (47666646..47990075, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (50150435..50411430, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9388 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:49917323-49918522 Neighboring gene DTW domain containing 1 Neighboring gene NANOG hESC enhancer GRCh37_chr15:49990770-49991300 Neighboring gene ring finger protein, LIM domain interacting pseudogene 3 Neighboring gene uncharacterized LOC102724587 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:50201373-50201873 Neighboring gene Sharpr-MPRA regulatory region 771 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9389 Neighboring gene RNA, 5S ribosomal pseudogene 394 Neighboring gene Sharpr-MPRA regulatory region 7155 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9390 Neighboring gene NANOG hESC enhancer GRCh37_chr15:50408634-50409147 Neighboring gene ATP8B4 intron CAGE-defined high expression enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6423 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6424 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:50502954-50503533 Neighboring gene solute carrier family 27 member 2 Neighboring gene RNA, 7SL, cytoplasmic 494, pseudogene Neighboring gene histidine decarboxylase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Analysis of ATP8B4 F436L Missense Variant in a Large Systemic Sclerosis Cohort. López-Isac E, et al. Arthritis Rheumatol, 2017 Jun. PMID 28141915
    2. Identification of Rare Variants in ATP8B4 as a Risk Factor for Systemic Sclerosis by Whole-Exome Sequencing. Gao L, et al. Arthritis Rheumatol, 2016 Jan. PMID 26473621, Free PMC Article
    3. Translocation t(11;14) (q13;q32) and genomic imbalances in multi-ethnic multiple myeloma patients: a Malaysian study. Ni IB, et al. Hematol Rep, 2012 Jul 11. PMID 23087808, Free PMC Article
    4. Expression profiles and potential functions of circular RNAs in extracellular vesicles isolated from radioresistant glioma cells. Zhao M, et al. Oncol Rep, 2019 Mar. PMID 30664179
    5. FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body. Harris MJ, et al. Biochim Biophys Acta, 2003 Jul 21. PMID 12880872

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study did not find statistically significant differences in the frequency of the ATP8B4 rs55687265*C allele between the SSc patients and controls.
      Title: Analysis of ATP8B4 F436L Missense Variant in a Large Systemic Sclerosis Cohort.
    2. Study found that circATP8B4 in extracellular vesicles isolated from radioresistant U251 glioma cells acts as a U251 miR766 sponge, which may be involved in glioma radioresistance.
      Title: Expression profiles and potential functions of circular RNAs in extracellular vesicles isolated from radioresistant glioma cells.
    3. ATP8B4 gene was associated with a significant increase in the risk of systemic sclerosis. ATP8B4 is overexpressed in systemic sclerosis patients.
      Title: Identification of Rare Variants in ATP8B4 as a Risk Factor for Systemic Sclerosis by Whole-Exome Sequencing.
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    5. Genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ25418

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of phospholipid-translocating ATPase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in specific granule membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in tertiary granule membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable phospholipid-transporting ATPase IM
    Names
    ATPase, class I, type 8B, member 4
    P4-ATPase flippase complex alpha subunit ATP8B4
    potential phospholipid-transporting ATPase IM
    NP_079113.2
    XP_011520348.1
    XP_011520349.1
    XP_011520350.1
    XP_011520351.1
    XP_011520354.1
    XP_011520355.1
    XP_011520358.3
    XP_011520360.1
    XP_011520361.1
    XP_011520362.1
    XP_011520363.1
    XP_011520364.1
    XP_011520365.1
    XP_011520371.1
    XP_011520372.1
    XP_016878076.2
    XP_016878080.1
    XP_016878083.1
    XP_024305833.1
    XP_024305834.1
    XP_024305835.1
    XP_024305836.1
    XP_024305837.1
    XP_024305838.1
    XP_047289038.1
    XP_047289039.1
    XP_047289040.1
    XP_047289041.1
    XP_047289042.1
    XP_047289043.1
    XP_047289044.1
    XP_047289045.1
    XP_047289046.1
    XP_047289047.1
    XP_047289048.1
    XP_047289049.1
    XP_047289050.1
    XP_047289052.1
    XP_047289053.1
    XP_047289054.1
    XP_047289055.1
    XP_047289056.1
    XP_054234828.1
    XP_054234829.1
    XP_054234830.1
    XP_054234831.1
    XP_054234832.1
    XP_054234833.1
    XP_054234834.1
    XP_054234835.1
    XP_054234836.1
    XP_054234837.1
    XP_054234838.1
    XP_054234839.1
    XP_054234840.1
    XP_054234841.1
    XP_054234842.1
    XP_054234843.1
    XP_054234844.1
    XP_054234845.1
    XP_054234846.1
    XP_054234847.1
    XP_054234848.1
    XP_054234849.1
    XP_054234850.1
    XP_054234851.1
    XP_054234852.1
    XP_054234853.1
    XP_054234854.1
    XP_054234855.1
    XP_054234856.1
    XP_054234857.1
    XP_054234858.1
    XP_054234859.1
    XP_054234860.1
    XP_054234861.1
    XP_054234862.1
    XP_054234863.1
    XP_054234864.1
    XP_054234865.1
    XP_054234866.1
    XP_054234867.1
    XP_054234868.1
    XP_054234869.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024837.4 → NP_079113.2  probable phospholipid-transporting ATPase IM

      See identical proteins and their annotated locations for NP_079113.2

      Status: REVIEWED

      Source sequence(s)
      AC009753, BC057236, BC144297, BC144298, BE241899, BX647496
      Consensus CDS
      CCDS32238.1
      UniProtKB/Swiss-Prot
      Q8TF62, Q9H727
      Related
      ENSP00000284509.6, ENST00000284509.11
      Conserved Domains (1) summary
      cd02073
      Location:30 → 973
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    RNA

    1. NR_073596.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an additional internal exon and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC009753, AC016045, BC144298, BE241899, BX647496

    2. NR_073597.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC009753, BC144297, BC144298, BE241899, BX647496

    3. NR_073598.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate 5' exon and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB075819, AC009753, AC016045, AC025040, BX647496
      Related
      ENST00000559726.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      49858238..50181854 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522056.4 → XP_011520358.3  probable phospholipid-transporting ATPase IM isoform X3

      Conserved Domains (1) summary
      cd02073
      Location:30 → 1001
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    2. XM_047433096.1 → XP_047289052.1  probable phospholipid-transporting ATPase IM isoform X21

    3. XM_017022587.3 → XP_016878076.2  probable phospholipid-transporting ATPase IM isoform X6

      UniProtKB/Swiss-Prot
      Q8TF62, Q9H727
      Conserved Domains (1) summary
      cd02073
      Location:30 → 973
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    4. XM_047433082.1 → XP_047289038.1  probable phospholipid-transporting ATPase IM isoform X3

    5. XM_011522058.4 → XP_011520360.1  probable phospholipid-transporting ATPase IM isoform X15

      See identical proteins and their annotated locations for XP_011520360.1

      Conserved Domains (4) summary
      TIGR01652
      Location:17 → 1021
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam13246
      Location:392 → 488
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16212
      Location:760 → 1014
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:729 → 760
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    6. XM_047433094.1 → XP_047289050.1  probable phospholipid-transporting ATPase IM isoform X21

    7. XM_047433090.1 → XP_047289046.1  probable phospholipid-transporting ATPase IM isoform X13

    8. XM_047433088.1 → XP_047289044.1  probable phospholipid-transporting ATPase IM isoform X11

    9. XM_047433093.1 → XP_047289049.1  probable phospholipid-transporting ATPase IM isoform X19

    10. XM_047433089.1 → XP_047289045.1  probable phospholipid-transporting ATPase IM isoform X12

    11. XM_047433083.1 → XP_047289039.1  probable phospholipid-transporting ATPase IM isoform X6

      UniProtKB/Swiss-Prot
      Q8TF62, Q9H727
      Related
      ENSP00000453169.1, ENST00000559829.5

    12. XM_011522047.3 → XP_011520349.1  probable phospholipid-transporting ATPase IM isoform X3

      See identical proteins and their annotated locations for XP_011520349.1

      Conserved Domains (1) summary
      cd02073
      Location:30 → 1001
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    13. XM_011522052.4 → XP_011520354.1  probable phospholipid-transporting ATPase IM isoform X3

      See identical proteins and their annotated locations for XP_011520354.1

      Conserved Domains (1) summary
      cd02073
      Location:30 → 1001
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    14. XM_011522048.2 → XP_011520350.1  probable phospholipid-transporting ATPase IM isoform X3

      See identical proteins and their annotated locations for XP_011520350.1

      Conserved Domains (1) summary
      cd02073
      Location:30 → 1001
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    15. XM_011522053.2 → XP_011520355.1  probable phospholipid-transporting ATPase IM isoform X3

      See identical proteins and their annotated locations for XP_011520355.1

      Conserved Domains (1) summary
      cd02073
      Location:30 → 1001
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    16. XM_011522049.3 → XP_011520351.1  probable phospholipid-transporting ATPase IM isoform X3

      See identical proteins and their annotated locations for XP_011520351.1

      Conserved Domains (1) summary
      cd02073
      Location:30 → 1001
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    17. XM_047433087.1 → XP_047289043.1  probable phospholipid-transporting ATPase IM isoform X10

    18. XM_047433084.1 → XP_047289040.1  probable phospholipid-transporting ATPase IM isoform X7

    19. XM_047433091.1 → XP_047289047.1  probable phospholipid-transporting ATPase IM isoform X14

    20. XM_047433085.1 → XP_047289041.1  probable phospholipid-transporting ATPase IM isoform X8

    21. XM_047433086.1 → XP_047289042.1  probable phospholipid-transporting ATPase IM isoform X9

    22. XM_024450065.2 → XP_024305833.1  probable phospholipid-transporting ATPase IM isoform X2

      Conserved Domains (1) summary
      cd02073
      Location:67 → 1010
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    23. XM_024450066.2 → XP_024305834.1  probable phospholipid-transporting ATPase IM isoform X4

      Conserved Domains (1) summary
      cd02073
      Location:67 → 985
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    24. XM_024450067.2 → XP_024305835.1  probable phospholipid-transporting ATPase IM isoform X5

      Conserved Domains (1) summary
      cd02073
      Location:67 → 975
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    25. XM_011522046.3 → XP_011520348.1  probable phospholipid-transporting ATPase IM isoform X1

      Conserved Domains (5) summary
      TIGR01652
      Location:65 → 1167
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam13246
      Location:538 → 634
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:51 → 116
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:906 → 1160
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:875 → 906
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    26. XM_017022591.2 → XP_016878080.1  probable phospholipid-transporting ATPase IM isoform X3

      Conserved Domains (1) summary
      cd02073
      Location:30 → 1001
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    27. XM_047433092.1 → XP_047289048.1  probable phospholipid-transporting ATPase IM isoform X18

    28. XM_017022594.1 → XP_016878083.1  probable phospholipid-transporting ATPase IM isoform X15

      Conserved Domains (4) summary
      TIGR01652
      Location:17 → 1021
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam13246
      Location:392 → 488
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16212
      Location:760 → 1014
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:729 → 760
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    29. XM_011522059.1 → XP_011520361.1  probable phospholipid-transporting ATPase IM isoform X16

      Conserved Domains (4) summary
      TIGR01652
      Location:11 → 1015
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam13246
      Location:386 → 482
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16212
      Location:754 → 1008
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:723 → 754
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    30. XM_011522061.1 → XP_011520363.1  probable phospholipid-transporting ATPase IM isoform X17

      See identical proteins and their annotated locations for XP_011520363.1

      Conserved Domains (1) summary
      cd02073
      Location:2 → 874
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    31. XM_011522060.1 → XP_011520362.1  probable phospholipid-transporting ATPase IM isoform X17

      See identical proteins and their annotated locations for XP_011520362.1

      Conserved Domains (1) summary
      cd02073
      Location:2 → 874
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    32. XM_047433098.1 → XP_047289054.1  probable phospholipid-transporting ATPase IM isoform X23

    33. XM_011522062.1 → XP_011520364.1  probable phospholipid-transporting ATPase IM isoform X17

      See identical proteins and their annotated locations for XP_011520364.1

      Conserved Domains (1) summary
      cd02073
      Location:2 → 874
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    34. XM_011522063.1 → XP_011520365.1  probable phospholipid-transporting ATPase IM isoform X17

      See identical proteins and their annotated locations for XP_011520365.1

      Conserved Domains (1) summary
      cd02073
      Location:2 → 874
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    35. XM_047433097.1 → XP_047289053.1  probable phospholipid-transporting ATPase IM isoform X23

    36. XM_024450069.1 → XP_024305837.1  probable phospholipid-transporting ATPase IM isoform X22

      Conserved Domains (1) summary
      cd02073
      Location:7 → 789
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    37. XM_011522069.2 → XP_011520371.1  probable phospholipid-transporting ATPase IM isoform X24

      See identical proteins and their annotated locations for XP_011520371.1

      Conserved Domains (5) summary
      COG0474
      Location:1 → 799
      MgtA; Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism]
      TIGR01484
      Location:396 → 577
      HAD-SF-IIB; HAD-superfamily hydrolase, subfamily IIB
      pfam13246
      Location:218 → 314
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16212
      Location:586 → 840
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:555 → 586
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    38. XM_011522070.2 → XP_011520372.1  probable phospholipid-transporting ATPase IM isoform X27

      Conserved Domains (5) summary
      COG0474
      Location:7 → 601
      MgtA; Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism]
      TIGR01484
      Location:198 → 379
      HAD-SF-IIB; HAD-superfamily hydrolase, subfamily IIB
      pfam13246
      Location:20 → 116
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16212
      Location:388 → 642
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:357 → 388
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    39. XM_024450068.2 → XP_024305836.1  probable phospholipid-transporting ATPase IM isoform X20

      Conserved Domains (1) summary
      cd02073
      Location:67 → 1038
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    40. XM_047433099.1 → XP_047289055.1  probable phospholipid-transporting ATPase IM isoform X25

    41. XM_047433100.1 → XP_047289056.1  probable phospholipid-transporting ATPase IM isoform X26

      UniProtKB/TrEMBL
      H0YMP8
      Related
      ENSP00000453690.1, ENST00000557955.5

    42. XM_024450070.2 → XP_024305838.1  probable phospholipid-transporting ATPase IM isoform X28

      UniProtKB/TrEMBL
      H0YMP8
      Conserved Domains (1) summary
      cd02073
      Location:67 → 706
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    RNA

    1. XR_002957687.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      47666646..47990075 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378873.1 → XP_054234848.1  probable phospholipid-transporting ATPase IM isoform X3

    2. XM_054378886.1 → XP_054234861.1  probable phospholipid-transporting ATPase IM isoform X21

    3. XM_054378865.1 → XP_054234840.1  probable phospholipid-transporting ATPase IM isoform X6

    4. XM_054378860.1 → XP_054234835.1  probable phospholipid-transporting ATPase IM isoform X3

    5. XM_054378857.1 → XP_054234832.1  probable phospholipid-transporting ATPase IM isoform X3

    6. XM_054378876.1 → XP_054234851.1  probable phospholipid-transporting ATPase IM isoform X15

    7. XM_054378870.1 → XP_054234845.1  probable phospholipid-transporting ATPase IM isoform X11

    8. XM_054378885.1 → XP_054234860.1  probable phospholipid-transporting ATPase IM isoform X21

    9. XM_054378872.1 → XP_054234847.1  probable phospholipid-transporting ATPase IM isoform X13

    10. XM_054378883.1 → XP_054234858.1  probable phospholipid-transporting ATPase IM isoform X19

    11. XM_054378871.1 → XP_054234846.1  probable phospholipid-transporting ATPase IM isoform X12

    12. XM_054378864.1 → XP_054234839.1  probable phospholipid-transporting ATPase IM isoform X6

    13. XM_054378859.1 → XP_054234834.1  probable phospholipid-transporting ATPase IM isoform X3

    14. XM_054378858.1 → XP_054234833.1  probable phospholipid-transporting ATPase IM isoform X3

    15. XM_054378855.1 → XP_054234830.1  probable phospholipid-transporting ATPase IM isoform X3

    16. XM_054378856.1 → XP_054234831.1  probable phospholipid-transporting ATPase IM isoform X3

    17. XM_054378869.1 → XP_054234844.1  probable phospholipid-transporting ATPase IM isoform X10

    18. XM_054378866.1 → XP_054234841.1  probable phospholipid-transporting ATPase IM isoform X7

    19. XM_054378874.1 → XP_054234849.1  probable phospholipid-transporting ATPase IM isoform X14

    20. XM_054378867.1 → XP_054234842.1  probable phospholipid-transporting ATPase IM isoform X8

    21. XM_054378868.1 → XP_054234843.1  probable phospholipid-transporting ATPase IM isoform X9

    22. XM_054378854.1 → XP_054234829.1  probable phospholipid-transporting ATPase IM isoform X2

    23. XM_054378862.1 → XP_054234837.1  probable phospholipid-transporting ATPase IM isoform X4

    24. XM_054378863.1 → XP_054234838.1  probable phospholipid-transporting ATPase IM isoform X5

    25. XM_054378853.1 → XP_054234828.1  probable phospholipid-transporting ATPase IM isoform X1

    26. XM_054378861.1 → XP_054234836.1  probable phospholipid-transporting ATPase IM isoform X3

    27. XM_054378882.1 → XP_054234857.1  probable phospholipid-transporting ATPase IM isoform X18

    28. XM_054378875.1 → XP_054234850.1  probable phospholipid-transporting ATPase IM isoform X15

    29. XM_054378877.1 → XP_054234852.1  probable phospholipid-transporting ATPase IM isoform X16

    30. XM_054378879.1 → XP_054234854.1  probable phospholipid-transporting ATPase IM isoform X17

    31. XM_054378878.1 → XP_054234853.1  probable phospholipid-transporting ATPase IM isoform X17

    32. XM_054378889.1 → XP_054234864.1  probable phospholipid-transporting ATPase IM isoform X23

    33. XM_054378880.1 → XP_054234855.1  probable phospholipid-transporting ATPase IM isoform X17

    34. XM_054378881.1 → XP_054234856.1  probable phospholipid-transporting ATPase IM isoform X17

    35. XM_054378888.1 → XP_054234863.1  probable phospholipid-transporting ATPase IM isoform X23

    36. XM_054378887.1 → XP_054234862.1  probable phospholipid-transporting ATPase IM isoform X22

    37. XM_054378890.1 → XP_054234865.1  probable phospholipid-transporting ATPase IM isoform X24

    38. XM_054378893.1 → XP_054234868.1  probable phospholipid-transporting ATPase IM isoform X27

    39. XM_054378884.1 → XP_054234859.1  probable phospholipid-transporting ATPase IM isoform X20

    40. XM_054378891.1 → XP_054234866.1  probable phospholipid-transporting ATPase IM isoform X25

    41. XM_054378892.1 → XP_054234867.1  probable phospholipid-transporting ATPase IM isoform X26

      UniProtKB/TrEMBL
      H0YMP8

    42. XM_054378894.1 → XP_054234869.1  probable phospholipid-transporting ATPase IM isoform X28

      UniProtKB/TrEMBL
      H0YMP8

    RNA

    1. XR_008489011.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TF62.3 GenPept UniProtKB/Swiss-Prot:Q8TF62

    Gene LinkOut

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