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    GRIK5 glutamate ionotropic receptor kainate type subunit 5 [ Homo sapiens (human) ]

    Gene ID: 2901, updated on 10-Dec-2024

    Summary

    Official Symbol
    GRIK5provided by HGNC
    Official Full Name
    glutamate ionotropic receptor kainate type subunit 5provided by HGNC
    Primary source
    HGNC:HGNC:4583
    See related
    Ensembl:ENSG00000105737 MIM:600283; AllianceGenome:HGNC:4583
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KA2; EAA2; GRIK2; GluK5
    Summary
    This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
    Expression
    Broad expression in testis (RPKM 5.6), brain (RPKM 5.5) and 14 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See GRIK5 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (41998324..42070206, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (44817686..44889570, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42502476..42574358, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10679 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10680 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14695 Neighboring gene Rab acceptor 1 Neighboring gene ATPase Na+/K+ transporting subunit alpha 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10682 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:42536134-42536906 Neighboring gene Sharpr-MPRA regulatory regions 411/7488 and 4104 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:42539441-42539940 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14697 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14698 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14699 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10683 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10684 Neighboring gene zinc finger protein 574 Neighboring gene POU class 2 homeobox 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14700 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10685 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14701 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14702 Neighboring gene Sharpr-MPRA regulatory region 1615 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42653684-42654184 Neighboring gene microRNA 4323 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42654185-42654685 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42659146-42659674 Neighboring gene long non-coding regulator of POU2F2 Neighboring gene POU2F2 antisense RNA 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (19 hits/1264 screens)

    EBI GWAS Catalog

    Description
    Genome-wide association study on bipolar disorder in the Bulgarian population.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in cell projection  
    located_in endoplasmic reticulum  
    located_in hippocampal mossy fiber to CA3 synapse  
    part_of kainate selective glutamate receptor complex  
    located_in nucleoplasm  
    colocalizes_with plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynaptic density membrane  
    is_active_in presynaptic membrane  

    General protein information

    Preferred Names
    glutamate receptor ionotropic, kainate 5
    Names
    excitatory amino acid receptor 2
    glutamate receptor KA2
    putative NMDtranscript(altDon_e2)
    putative NMDtranscript(del_e13-e15)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301030.2 → NP_001287959.1  glutamate receptor ionotropic, kainate 5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001287959.1

      Status: REVIEWED

      Source sequence(s)
      AC010616, AC020946, AC022515
      Consensus CDS
      CCDS77305.1
      UniProtKB/Swiss-Prot
      Q16478
      Related
      ENSP00000301218.3, ENST00000301218.8
      Conserved Domains (4) summary
      cd06394
      Location:25 → 399
      PBP1_iGluR_Kainate_KA1_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor
      pfam00060
      Location:545 → 815
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42 → 379
      ANF_receptor; Receptor family ligand binding region
      cl21456
      Location:414 → 784
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    2. NM_002088.5 → NP_002079.3  glutamate receptor ionotropic, kainate 5 isoform 2 precursor

      See identical proteins and their annotated locations for NP_002079.3

      Status: REVIEWED

      Source sequence(s)
      AC010616, AC020946, AC022515
      Consensus CDS
      CCDS12595.1
      UniProtKB/Swiss-Prot
      Q16478, Q8WWG8
      Related
      ENSP00000470251.1, ENST00000593562.6
      Conserved Domains (4) summary
      cd06394
      Location:25 → 399
      PBP1_iGluR_Kainate_KA1_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor
      pfam00060
      Location:545 → 815
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42 → 379
      ANF_receptor; Receptor family ligand binding region
      cl21456
      Location:414 → 784
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      41998324..42070206 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526862.3 → XP_011525164.1  glutamate receptor ionotropic, kainate 5 isoform X2

      Conserved Domains (4) summary
      cd06394
      Location:25 → 399
      PBP1_iGluR_Kainate_KA1_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor
      pfam00060
      Location:546 → 816
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42 → 379
      ANF_receptor; Receptor family ligand binding region
      cl21456
      Location:414 → 785
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    2. XM_011526865.2 → XP_011525167.1  glutamate receptor ionotropic, kainate 5 isoform X1

      Conserved Domains (4) summary
      cd06394
      Location:25 → 399
      PBP1_iGluR_Kainate_KA1_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor
      pfam00060
      Location:546 → 816
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42 → 379
      ANF_receptor; Receptor family ligand binding region
      cl21456
      Location:414 → 785
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    3. XM_047438705.1 → XP_047294661.1  glutamate receptor ionotropic, kainate 5 isoform X3

    4. XM_047438706.1 → XP_047294662.1  glutamate receptor ionotropic, kainate 5 isoform X5

    5. XM_011526869.3 → XP_011525171.1  glutamate receptor ionotropic, kainate 5 isoform X4

      Conserved Domains (3) summary
      cd06394
      Location:25 → 399
      PBP1_iGluR_Kainate_KA1_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor
      pfam01094
      Location:42 → 379
      ANF_receptor; Receptor family ligand binding region
      cl21456
      Location:414 → 613
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    6. XM_011526871.3 → XP_011525173.1  glutamate receptor ionotropic, kainate 5 isoform X7

      UniProtKB/TrEMBL
      A0A8D9UIS7
      Conserved Domains (3) summary
      cd06394
      Location:25 → 399
      PBP1_iGluR_Kainate_KA1_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor
      pfam01094
      Location:42 → 379
      ANF_receptor; Receptor family ligand binding region
      cl21456
      Location:414 → 491
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    7. XM_011526870.3 → XP_011525172.1  glutamate receptor ionotropic, kainate 5 isoform X6

      Conserved Domains (3) summary
      cd06394
      Location:25 → 399
      PBP1_iGluR_Kainate_KA1_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor
      pfam01094
      Location:42 → 379
      ANF_receptor; Receptor family ligand binding region
      cl21456
      Location:414 → 491
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

    RNA

    1. XR_935810.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      44817686..44889570 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320746.1 → XP_054176721.1  glutamate receptor ionotropic, kainate 5 isoform X2

    2. XM_054320745.1 → XP_054176720.1  glutamate receptor ionotropic, kainate 5 isoform X1

    3. XM_054320747.1 → XP_054176722.1  glutamate receptor ionotropic, kainate 5 isoform X3

    4. XM_054320748.1 → XP_054176723.1  glutamate receptor ionotropic, kainate 5 isoform X4

    5. XM_054320749.1 → XP_054176724.1  glutamate receptor ionotropic, kainate 5 isoform X5

    6. XM_054320751.1 → XP_054176726.1  glutamate receptor ionotropic, kainate 5 isoform X7

      UniProtKB/TrEMBL
      A0A8D9UIS7
    7. XM_054320750.1 → XP_054176725.1  glutamate receptor ionotropic, kainate 5 isoform X6

    RNA

    1. XR_008485135.1 RNA Sequence

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