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    ADCY7 adenylate cyclase 7 [ Homo sapiens (human) ]

    Gene ID: 113, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ADCY7provided by HGNC
    Official Full Name
    adenylate cyclase 7provided by HGNC
    Primary source
    HGNC:HGNC:238
    See related
    Ensembl:ENSG00000121281 MIM:600385; AllianceGenome:HGNC:238
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AC7
    Summary
    This gene encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences. Several transcript variants have been observed for this gene, but the full-length natures of only two have been determined so far. [provided by RefSeq, Oct 2013]
    Expression
    Broad expression in spleen (RPKM 22.5), appendix (RPKM 19.0) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ADCY7 in Genome Data Viewer
    Location:
    16q12.1
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (50244699..50318135)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (56042542..56115969)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (50300462..50352046)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900375 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:50186273-50187230 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7476 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7477 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10808 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10809 Neighboring gene MPRA-validated peak2589 silencer Neighboring gene terminal nucleotidyltransferase 4B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:50217888-50218450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:50218451-50219012 Neighboring gene Sharpr-MPRA regulatory region 14159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10810 Neighboring gene Sharpr-MPRA regulatory region 8986 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:50278238-50278950 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:50278951-50279662 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7478 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:50280376-50281087 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:50288095-50288594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10811 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10812 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:50299606-50300199 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:50305212-50306046 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:50306047-50306881 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10814 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:50317845-50318346 Neighboring gene microRNA 6771 Neighboring gene Sharpr-MPRA regulatory region 2137 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:50347343-50348542 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:50353005-50354204 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10815 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10816 Neighboring gene bromodomain containing 7 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7481 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7482 Neighboring gene Sharpr-MPRA regulatory region 13482 Neighboring gene long intergenic non-protein coding RNA 2178

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Localization of the gene for a novel human adenylyl cyclase (ADCY7) to chromosome 16. Hellevuo K, et al. Hum Genet, 1995 Feb. PMID 7860067
    2. Human adenylyl cyclase type 7 contains polymorphic repeats in the 3' untranslated region: investigations of association with alcoholism. Hellevuo K, et al. Am J Med Genet, 1997 Feb 21. PMID 9034014
    3. Construction of soluble adenylyl cyclase from human membrane-bound type 7 adenylyl cyclase. Yan SZ, et al. Methods Enzymol, 2002. PMID 11665607
    4. A soluble C1b protein and its regulation of soluble type 7 adenylyl cyclase. Beeler JA, et al. Biochemistry, 2004 Dec 14. PMID 15581358
    5. Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7. Luo Y, et al. Nat Genet, 2017 Feb. PMID 28067910, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hsa_circ_0008234 facilitates proliferation of cutaneous squamous cell carcinoma through targeting miR-127-5p to regulate ADCY7.
      Title: Hsa_circ_0008234 facilitates proliferation of cutaneous squamous cell carcinoma through targeting miR-127-5p to regulate ADCY7.
    2. CRISPR/Cas9 ADCY7 Knockout Stimulates the Insulin Secretion Pathway Leading to Excessive Insulin Secretion.
      Title: CRISPR/Cas9 ADCY7 Knockout Stimulates the Insulin Secretion Pathway Leading to Excessive Insulin Secretion.
    3. AC7 and miR-192 might be new biomarkers and therapeutic targets for patients with relapsed acute promyelocytic leukemia.
      Title: Adenylate cyclase 7 regulated by miR-192 promotes ATRA-induced differentiation of acute promyelocytic leukemia cells.
    4. We discovered a 0.6% frequency missense variant in ADCY7.
      Title: Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7.
    5. The stronger TNF-alpha responses in young males compared to females may be partly associated with male-specific down-regulation of ADCY7 and ADCY9.
      Title: Higher TNFα responses in young males compared to females are associated with attenuation of monocyte adenylyl cyclase expression.
    6. The ADCY7 deficiency resulted in decreased cell growth, elevated apoptosis, and lower c-Myc expression in cultured leukemia cells obtained from acute myeloid leukemia patients.
      Title: ADCY7 supports development of acute myeloid leukemia.
    7. evidence implicates ADCY7 in the modulation of mood regulatory neural mechanisms and, possibly, risk for and pathophysiology of depression.
      Title: Adenylate cyclase 7 is implicated in the biology of depression and modulation of affective neural circuitry.
    8. we found that single nucleotide polymorphisms in ADCY7 associate with alcohol dependence in women, and these markers are also associated with ADCY7 expression (messenger RNA) levels.
      Title: Sex-specific role for adenylyl cyclase type 7 in alcohol dependence.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetical genomic determinants of alcohol consumption in rats and humans.
    10. soluble adenylyl cyclase is responsive to both CO(2) and bicarbonate ion
      Title: Stimulation of mammalian G-protein-responsive adenylyl cyclases by carbon dioxide.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The addition of HIV-1 gp120 with TNF-alpha to human B-cells stimulates cAMP production in a dose-dependent manner PubMed
    Envelope transmembrane glycoprotein gp41 env Secretion of IL-10 is upregulated by HIV-1 gp41 in monocytes through activation of cAMP/adenylate cyclase and p70 (S6)-kinase; up-regulation of IL-10 is paralleled by an enhanced expression of the chemokine receptor CCR5 PubMed
    Nef nef HIV-1 induces the upregulation of complement factor C3 in astrocytes and neurons through signaling pathways that involve protein kinase C and adenylate cyclase activation, which is an effect that may contribute to the pathogenesis of AIDS in the brain PubMed
    Tat tat HIV-1 Tat inhibits adenylyl cyclase activity in microglia and astrocyte cultures from neonatal rat brain, suggesting that Tat inhibition of cAMP synthesis may contribute to neuronal degeneration and cell death associated with HIV infection PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ36387, KIAA0037

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenylate cyclase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cAMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cAMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to ethanol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to lithium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maternal process involved in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cytokine production involved in inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of adaptive immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    adenylate cyclase type 7
    Names
    ATP pyrophosphate-lyase 7
    adenylate cyclase type VII
    adenylyl cyclase 7
    NP_001105.1
    NP_001272986.1
    XP_011521137.1
    XP_011521138.1
    XP_011521139.1
    XP_011521140.1
    XP_011521141.1
    XP_011521142.1
    XP_011521144.1
    XP_016878385.1
    XP_016878387.1
    XP_047289506.1
    XP_047289507.1
    XP_047289508.1
    XP_047289509.1
    XP_047289510.1
    XP_047289511.1
    XP_047289512.1
    XP_047289513.1
    XP_047289514.1
    XP_047289515.1
    XP_047289516.1
    XP_047289517.1
    XP_047289518.1
    XP_047289519.1
    XP_047289520.1
    XP_047289521.1
    XP_047289522.1
    XP_047289523.1
    XP_047289524.1
    XP_047289525.1
    XP_047289526.1
    XP_047289527.1
    XP_054235453.1
    XP_054235454.1
    XP_054235455.1
    XP_054235456.1
    XP_054235457.1
    XP_054235458.1
    XP_054235459.1
    XP_054235460.1
    XP_054235461.1
    XP_054235462.1
    XP_054235463.1
    XP_054235464.1
    XP_054235465.1
    XP_054235466.1
    XP_054235467.1
    XP_054235468.1
    XP_054235469.1
    XP_054235470.1
    XP_054235471.1
    XP_054235472.1
    XP_054235473.1
    XP_054235474.1
    XP_054235475.1
    XP_054235476.1
    XP_054235477.1
    XP_054235478.1
    XP_054235479.1
    XP_054235480.1
    XP_054235481.1
    XP_054235482.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114.5 → NP_001105.1  adenylate cyclase type 7 isoform 1

      See identical proteins and their annotated locations for NP_001105.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA740624, AC007597, BC039891, BC126271, D25538, HY102720
      Consensus CDS
      CCDS10741.1
      UniProtKB/Swiss-Prot
      A0AVA6, P51828
      Related
      ENSP00000501053.1, ENST00000673801.1
      Conserved Domains (4) summary
      smart00044
      Location:224 → 429
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:871 → 1067
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:485 → 592
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:73 → 249
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    2. NM_001286057.2 → NP_001272986.1  adenylate cyclase type 7 isoform 2

      See identical proteins and their annotated locations for NP_001272986.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC007597
      Consensus CDS
      CCDS73882.1
      UniProtKB/TrEMBL
      B3KSJ0, F5H4D1
      Related
      ENSP00000457409.2, ENST00000566433.6
      Conserved Domains (4) summary
      smart00044
      Location:224 → 429
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:270 → 432
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:485 → 592
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:73 → 249
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      50244699..50318135
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433551.1 → XP_047289507.1  adenylate cyclase type 7 isoform X1

    2. XM_047433560.1 → XP_047289516.1  adenylate cyclase type 7 isoform X2

      UniProtKB/Swiss-Prot
      A0AVA6, P51828

    3. XM_047433552.1 → XP_047289508.1  adenylate cyclase type 7 isoform X1

    4. XM_047433563.1 → XP_047289519.1  adenylate cyclase type 7 isoform X2

      UniProtKB/Swiss-Prot
      A0AVA6, P51828

    5. XM_011522837.4 → XP_011521139.1  adenylate cyclase type 7 isoform X1

      See identical proteins and their annotated locations for XP_011521139.1

      Conserved Domains (4) summary
      smart00044
      Location:224 → 429
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:871 → 1073
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:485 → 592
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:73 → 249
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    6. XM_047433556.1 → XP_047289512.1  adenylate cyclase type 7 isoform X2

      UniProtKB/Swiss-Prot
      A0AVA6, P51828
      Related
      ENSP00000254235.3, ENST00000254235.7

    7. XM_047433568.1 → XP_047289524.1  adenylate cyclase type 7 isoform X5

      UniProtKB/TrEMBL
      B3KSJ0, F5H4D1

    8. XM_011522842.3 → XP_011521144.1  adenylate cyclase type 7 isoform X1

      See identical proteins and their annotated locations for XP_011521144.1

      Conserved Domains (4) summary
      smart00044
      Location:224 → 429
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:871 → 1073
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:485 → 592
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:73 → 249
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    9. XM_047433557.1 → XP_047289513.1  adenylate cyclase type 7 isoform X2

      UniProtKB/Swiss-Prot
      A0AVA6, P51828

    10. XM_011522836.3 → XP_011521138.1  adenylate cyclase type 7 isoform X1

      See identical proteins and their annotated locations for XP_011521138.1

      Conserved Domains (4) summary
      smart00044
      Location:224 → 429
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:871 → 1073
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:485 → 592
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:73 → 249
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    11. XM_047433550.1 → XP_047289506.1  adenylate cyclase type 7 isoform X1

    12. XM_047433559.1 → XP_047289515.1  adenylate cyclase type 7 isoform X2

      UniProtKB/Swiss-Prot
      A0AVA6, P51828

    13. XM_011522840.4 → XP_011521142.1  adenylate cyclase type 7 isoform X1

      See identical proteins and their annotated locations for XP_011521142.1

      Conserved Domains (4) summary
      smart00044
      Location:224 → 429
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:871 → 1073
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:485 → 592
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:73 → 249
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    14. XM_047433555.1 → XP_047289511.1  adenylate cyclase type 7 isoform X2

      UniProtKB/Swiss-Prot
      A0AVA6, P51828
      Related
      ENSP00000378187.2, ENST00000394697.7

    15. XM_047433567.1 → XP_047289523.1  adenylate cyclase type 7 isoform X5

      UniProtKB/TrEMBL
      B3KSJ0, F5H4D1

    16. XM_017022898.2 → XP_016878387.1  adenylate cyclase type 7 isoform X5

      UniProtKB/TrEMBL
      B3KSJ0, F5H4D1
      Conserved Domains (4) summary
      smart00044
      Location:224 → 429
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:270 → 432
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:485 → 592
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:73 → 249
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    17. XM_047433569.1 → XP_047289525.1  adenylate cyclase type 7 isoform X5

      UniProtKB/TrEMBL
      B3KSJ0, F5H4D1

    18. XM_047433561.1 → XP_047289517.1  adenylate cyclase type 7 isoform X2

      UniProtKB/Swiss-Prot
      A0AVA6, P51828

    19. XM_011522839.3 → XP_011521141.1  adenylate cyclase type 7 isoform X1

      See identical proteins and their annotated locations for XP_011521141.1

      Conserved Domains (4) summary
      smart00044
      Location:224 → 429
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:871 → 1073
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:485 → 592
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:73 → 249
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    20. XM_047433558.1 → XP_047289514.1  adenylate cyclase type 7 isoform X2

      UniProtKB/Swiss-Prot
      A0AVA6, P51828

    21. XM_011522835.3 → XP_011521137.1  adenylate cyclase type 7 isoform X1

      See identical proteins and their annotated locations for XP_011521137.1

      Conserved Domains (4) summary
      smart00044
      Location:224 → 429
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:871 → 1073
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:485 → 592
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:73 → 249
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    22. XM_047433554.1 → XP_047289510.1  adenylate cyclase type 7 isoform X2

      UniProtKB/Swiss-Prot
      A0AVA6, P51828

    23. XM_017022896.1 → XP_016878385.1  adenylate cyclase type 7 isoform X3

    24. XM_047433564.1 → XP_047289520.1  adenylate cyclase type 7 isoform X4

    25. XM_047433570.1 → XP_047289526.1  adenylate cyclase type 7 isoform X6

      UniProtKB/TrEMBL
      B3KSJ0

    26. XM_047433566.1 → XP_047289522.1  adenylate cyclase type 7 isoform X5

      UniProtKB/TrEMBL
      B3KSJ0, F5H4D1

    27. XM_047433565.1 → XP_047289521.1  adenylate cyclase type 7 isoform X5

      UniProtKB/TrEMBL
      B3KSJ0, F5H4D1

    28. XM_047433571.1 → XP_047289527.1  adenylate cyclase type 7 isoform X7

      UniProtKB/TrEMBL
      B3KSJ0

    29. XM_047433553.1 → XP_047289509.1  adenylate cyclase type 7 isoform X1

    30. XM_011522838.3 → XP_011521140.1  adenylate cyclase type 7 isoform X1

      See identical proteins and their annotated locations for XP_011521140.1

      Conserved Domains (4) summary
      smart00044
      Location:224 → 429
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:871 → 1073
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:485 → 592
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:73 → 249
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    31. XM_047433562.1 → XP_047289518.1  adenylate cyclase type 7 isoform X2

      UniProtKB/Swiss-Prot
      A0AVA6, P51828

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      56042542..56115969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379493.1 → XP_054235468.1  adenylate cyclase type 7 isoform X2

      UniProtKB/Swiss-Prot
      A0AVA6, P51828

    2. XM_054379486.1 → XP_054235461.1  adenylate cyclase type 7 isoform X1

    3. XM_054379496.1 → XP_054235471.1  adenylate cyclase type 7 isoform X2

      UniProtKB/Swiss-Prot
      A0AVA6, P51828

    4. XM_054379484.1 → XP_054235459.1  adenylate cyclase type 7 isoform X1

    5. XM_054379505.1 → XP_054235480.1  adenylate cyclase type 7 isoform X5

      UniProtKB/TrEMBL
      B3KSJ0, F5H4D1

    6. XM_054379487.1 → XP_054235462.1  adenylate cyclase type 7 isoform X1

    7. XM_054379497.1 → XP_054235472.1  adenylate cyclase type 7 isoform X2

      UniProtKB/Swiss-Prot
      A0AVA6, P51828

    8. XM_054379481.1 → XP_054235456.1  adenylate cyclase type 7 isoform X1

    9. XM_054379490.1 → XP_054235465.1  adenylate cyclase type 7 isoform X2

      UniProtKB/Swiss-Prot
      A0AVA6, P51828

    10. XM_054379478.1 → XP_054235453.1  adenylate cyclase type 7 isoform X1

    11. XM_054379483.1 → XP_054235458.1  adenylate cyclase type 7 isoform X1

    12. XM_054379492.1 → XP_054235467.1  adenylate cyclase type 7 isoform X2

      UniProtKB/Swiss-Prot
      A0AVA6, P51828

    13. XM_054379479.1 → XP_054235454.1  adenylate cyclase type 7 isoform X1

    14. XM_054379489.1 → XP_054235464.1  adenylate cyclase type 7 isoform X2

      UniProtKB/Swiss-Prot
      A0AVA6, P51828

    15. XM_054379503.1 → XP_054235478.1  adenylate cyclase type 7 isoform X5

      UniProtKB/TrEMBL
      B3KSJ0, F5H4D1

    16. XM_054379501.1 → XP_054235476.1  adenylate cyclase type 7 isoform X5

      UniProtKB/TrEMBL
      B3KSJ0, F5H4D1

    17. XM_054379504.1 → XP_054235479.1  adenylate cyclase type 7 isoform X5

      UniProtKB/TrEMBL
      B3KSJ0, F5H4D1

    18. XM_054379494.1 → XP_054235469.1  adenylate cyclase type 7 isoform X2

      UniProtKB/Swiss-Prot
      A0AVA6, P51828

    19. XM_054379500.1 → XP_054235475.1  adenylate cyclase type 7 isoform X5

      UniProtKB/TrEMBL
      B3KSJ0, F5H4D1

    20. XM_054379506.1 → XP_054235481.1  adenylate cyclase type 7 isoform X6

      UniProtKB/TrEMBL
      B3KSJ0

    21. XM_054379507.1 → XP_054235482.1  adenylate cyclase type 7 isoform X7

      UniProtKB/TrEMBL
      B3KSJ0

    22. XM_054379480.1 → XP_054235455.1  adenylate cyclase type 7 isoform X1

    23. XM_054379488.1 → XP_054235463.1  adenylate cyclase type 7 isoform X2

      UniProtKB/Swiss-Prot
      A0AVA6, P51828

    24. XM_054379499.1 → XP_054235474.1  adenylate cyclase type 7 isoform X4

    25. XM_054379482.1 → XP_054235457.1  adenylate cyclase type 7 isoform X1

    26. XM_054379491.1 → XP_054235466.1  adenylate cyclase type 7 isoform X2

      UniProtKB/Swiss-Prot
      A0AVA6, P51828

    27. XM_054379502.1 → XP_054235477.1  adenylate cyclase type 7 isoform X5

      UniProtKB/TrEMBL
      B3KSJ0, F5H4D1

    28. XM_054379498.1 → XP_054235473.1  adenylate cyclase type 7 isoform X3

    29. XM_054379485.1 → XP_054235460.1  adenylate cyclase type 7 isoform X1

    30. XM_054379495.1 → XP_054235470.1  adenylate cyclase type 7 isoform X2

      UniProtKB/Swiss-Prot
      A0AVA6, P51828
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51828.1 GenPept UniProtKB/Swiss-Prot:P51828

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