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    ZNF569 zinc finger protein 569 [ Homo sapiens (human) ]

    Gene ID: 148266, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF569provided by HGNC
    Official Full Name
    zinc finger protein 569provided by HGNC
    Primary source
    HGNC:HGNC:24737
    See related
    Ensembl:ENSG00000196437 MIM:613904; AllianceGenome:HGNC:24737
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF; ZAP1; Zfp74
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 4.0), thyroid (RPKM 2.7) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF569 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (37411157..37469265, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (40212656..40270764, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37902059..37958346, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14541 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:37809147-37810044 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:37811117-37811765 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:37811766-37812414 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37824558-37825500 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37825501-37826442 Neighboring gene zinc finger protein 875 Neighboring gene MPRA-validated peak3463 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14546 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10555 Neighboring gene zinc finger protein 527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14548 Neighboring gene zinc finger protein 570 Neighboring gene ZNF793 antisense RNA 1 (head to head) Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37996759-37997550 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37997551-37998342 Neighboring gene zinc finger protein 793 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:38020876-38021698 Neighboring gene uncharacterized LOC124904708 Neighboring gene ZNF571 antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ZNF569, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway. Huang X, et al. Biochem Biophys Res Commun, 2006 Aug 4. PMID 16793018
    2. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. Lichter P, et al. Genomics, 1992 Aug. PMID 1505991
    3. Characterization and mapping of human genes encoding zinc finger proteins. Bray P, et al. Proc Natl Acad Sci U S A, 1991 Nov 1. PMID 1946370, Free PMC Article
    4. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nozawa RS, et al. Nat Cell Biol, 2010 Jul. PMID 20562864
    5. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. Dart AE, et al. J Cell Biol, 2015 Nov 23. PMID 26598620, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF569 protein may act as a transcriptional repressor that suppresses MAPK signaling pathway to mediate cellular functions
      Title: ZNF569, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ32053

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 569
    Names
    DNA-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330482.2 → NP_001317411.1  zinc finger protein 569 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008806
      Consensus CDS
      CCDS82341.1
      UniProtKB/Swiss-Prot
      Q5MCW4
      Conserved Domains (2) summary
      COG5048
      Location:109 → 521
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:85 → 105
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_152484.3 → NP_689697.2  zinc finger protein 569 isoform 1

      See identical proteins and their annotated locations for NP_689697.2

      Status: VALIDATED

      Source sequence(s)
      AC008806, AK122846, AL833408, BC038737, CB151734
      Consensus CDS
      CCDS12503.1
      UniProtKB/Swiss-Prot
      A8K1S2, Q15925, Q17RR6, Q5MCW4, Q96MQ2
      Related
      ENSP00000325018.5, ENST00000316950.11
      Conserved Domains (3) summary
      smart00349
      Location:8 → 62
      KRAB; krueppel associated box
      COG5048
      Location:268 → 680
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:244 → 264
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      37411157..37469265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006723048.5 → XP_006723111.1  zinc finger protein 569 isoform X1

      See identical proteins and their annotated locations for XP_006723111.1

      UniProtKB/TrEMBL
      K7ELU1
      Conserved Domains (3) summary
      smart00349
      Location:32 → 86
      KRAB; krueppel associated box
      COG5048
      Location:292 → 704
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:268 → 288
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_011526538.4 → XP_011524840.1  zinc finger protein 569 isoform X1

      See identical proteins and their annotated locations for XP_011524840.1

      UniProtKB/TrEMBL
      K7ELU1
      Conserved Domains (3) summary
      smart00349
      Location:32 → 86
      KRAB; krueppel associated box
      COG5048
      Location:292 → 704
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:268 → 288
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_047438278.1 → XP_047294234.1  zinc finger protein 569 isoform X1

      UniProtKB/TrEMBL
      K7ELU1

    4. XM_017026379.2 → XP_016881868.1  zinc finger protein 569 isoform X3

      UniProtKB/Swiss-Prot
      Q5MCW4
      Related
      ENSP00000375993.2, ENST00000392150.2
      Conserved Domains (2) summary
      COG5048
      Location:109 → 521
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:85 → 105
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_006723047.5 → XP_006723110.1  zinc finger protein 569 isoform X1

      See identical proteins and their annotated locations for XP_006723110.1

      UniProtKB/TrEMBL
      K7ELU1
      Conserved Domains (3) summary
      smart00349
      Location:32 → 86
      KRAB; krueppel associated box
      COG5048
      Location:292 → 704
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:268 → 288
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. XM_006723046.3 → XP_006723109.1  zinc finger protein 569 isoform X1

      See identical proteins and their annotated locations for XP_006723109.1

      UniProtKB/TrEMBL
      K7ELU1
      Related
      ENSP00000466221.2, ENST00000448051.7
      Conserved Domains (3) summary
      smart00349
      Location:32 → 86
      KRAB; krueppel associated box
      COG5048
      Location:292 → 704
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:268 → 288
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. XM_047438277.1 → XP_047294233.1  zinc finger protein 569 isoform X1

      UniProtKB/TrEMBL
      K7ELU1

    8. XM_011526539.4 → XP_011524841.1  zinc finger protein 569 isoform X2

      See identical proteins and their annotated locations for XP_011524841.1

      UniProtKB/Swiss-Prot
      A8K1S2, Q15925, Q17RR6, Q5MCW4, Q96MQ2
      Related
      ENSP00000375992.2, ENST00000392149.6
      Conserved Domains (3) summary
      smart00349
      Location:8 → 62
      KRAB; krueppel associated box
      COG5048
      Location:268 → 680
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:244 → 264
      ZF_C2H2; C2H2 Zn finger [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      40212656..40270764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320011.1 → XP_054175986.1  zinc finger protein 569 isoform X1

      UniProtKB/TrEMBL
      K7ELU1

    2. XM_054320013.1 → XP_054175988.1  zinc finger protein 569 isoform X3

    3. XM_054320008.1 → XP_054175983.1  zinc finger protein 569 isoform X1

      UniProtKB/TrEMBL
      K7ELU1

    4. XM_054320009.1 → XP_054175984.1  zinc finger protein 569 isoform X1

      UniProtKB/TrEMBL
      K7ELU1

    5. XM_054320010.1 → XP_054175985.1  zinc finger protein 569 isoform X1

      UniProtKB/TrEMBL
      K7ELU1

    6. XM_054320012.1 → XP_054175987.1  zinc finger protein 569 isoform X2

      UniProtKB/Swiss-Prot
      A8K1S2, Q15925, Q17RR6, Q5MCW4, Q96MQ2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5MCW4.1 GenPept UniProtKB/Swiss-Prot:Q5MCW4

    Gene LinkOut

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