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    RTNLB13 Reticulan like protein B13 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816896, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RTNLB13
    Official Full Name
    Reticulan like protein B13
    Primary source
    TAIR:AT2G23640
    Locus tag
    AT2G23640
    See related
    Araport:AT2G23640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F26B6.29; Reticulan like protein B13
    Summary
    Encodes RTNLB13, a reticulon protein integral to the endoplasmic reticulum (ER) membrane that have the ability to shape the ER into tubules.
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    Genomic context

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    See RTNLB13 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_003071.7 (10057542..10059108)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene SKU5 similar 16 Neighboring gene ncRNA Neighboring gene tRNA-Met Neighboring gene LOB domain-containing protein 10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Curvature sensing amphipathic helix in the C-terminus of RTNLB13 is conserved in all endoplasmic reticulum shaping reticulons in Arabidopsis thaliana. Brooks RL, et al. Sci Rep, 2021 Mar 18. PMID 33737685, Free PMC Article
    2. Bacterial expression, purification and biophysical characterization of the smallest plant reticulon isoform, RTNLB13. Chow M, et al. Protein Expr Purif, 2018 Dec. PMID 29969670
    3. A C-terminal amphipathic helix is necessary for the in vivo tubule-shaping function of a plant reticulon. Breeze E, et al. Proc Natl Acad Sci U S A, 2016 Sep 27. PMID 27621477, Free PMC Article
    4. Transmembrane domain length is responsible for the ability of a plant reticulon to shape endoplasmic reticulum tubules in vivo. Tolley N, et al. Plant J, 2010 Nov. PMID 20969742
    5. Five Arabidopsis reticulon isoforms share endoplasmic reticulum location, topology, and membrane-shaping properties. Sparkes I, et al. Plant Cell, 2010 Apr. PMID 20424177, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Curvature sensing amphipathic helix in the C-terminus of RTNLB13 is conserved in all endoplasmic reticulum shaping reticulons in Arabidopsis thaliana.
      Title: Curvature sensing amphipathic helix in the C-terminus of RTNLB13 is conserved in all endoplasmic reticulum shaping reticulons in Arabidopsis thaliana.
    2. Bacterial expression, purification and molecular characterization of the smallest plant reticulon isoform, RTNLB13, has been reported.
      Title: Bacterial expression, purification and biophysical characterization of the smallest plant reticulon isoform, RTNLB13.
    3. the conserved amphipathic helix is a key structural feature for RTN13 function in vivo.[RTN13]
      Title: A C-terminal amphipathic helix is necessary for the in vivo tubule-shaping function of a plant reticulon.
    4. The length of the transmembrane regions is directly correlated with the ability of RTNLB13 to induce membrane tubulation.
      Title: Transmembrane domain length is responsible for the ability of a plant reticulon to shape endoplasmic reticulum tubules in vivo.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_127928.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within endoplasmic reticulum tubular network organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum tubular network organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic side of endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum tubular network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Reticulan like protein B13
    NP_565555.1
    • Reticulan like protein B13 (RTNLB13); CONTAINS InterPro DOMAIN/s: Reticulon (InterPro:IPR003388); BEST Arabidopsis thaliana protein match is: Reticulon family protein (TAIR:AT3G10915.3); Has 751 Blast hits to 751 proteins in 54 species: Archae - 0; Bacteria - 0; Metazoa - 324; Fungi - 0; Plants - 418; Viruses - 0; Other Eukaryotes - 9 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      10057542..10059108
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127928.3 → NP_565555.1  Reticulan like protein B13 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565555.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64837
      UniProtKB/TrEMBL
      A0A5S9X0W7
      Conserved Domains (1) summary
      pfam02453
      Location:16 → 170
      Reticulon; Reticulon
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O64837.1

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