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    MAP2A methionine aminopeptidase 2A [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819025, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MAP2A
    Official Full Name
    methionine aminopeptidase 2A
    Primary source
    TAIR:AT2G44180
    Locus tag
    AT2G44180
    See related
    Araport:AT2G44180
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F6E13.31; methionine aminopeptidase 2A
    Summary
    Encodes a MAP2 like methionine aminopeptidase. In MAP1A mutant background plants show an increased sensitivity to fumagillin resulting in defects in development. Phenotype is similar to RNAi lines which knock out all MAP2/MAP1 loci.
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    Genomic context

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    See MAP2A in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Sequence:
    Chromosome: 2; NC_003071.7 (18269211..18271941, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene methylenetetrahydrofolate reductase 2 Neighboring gene miscRNA Neighboring gene Acyl-CoA N-acyltransferases (NAT) superfamily protein Neighboring gene ENDOSPERM DEFECTIVE protein (DUF566) Neighboring gene pre-mRNA splicing factor domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional and developmental impact of cytosolic protein N-terminal methionine excision in Arabidopsis. Ross S, et al. Plant Physiol, 2005 Feb. PMID 15681659, Free PMC Article
    2. Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms. Giglione C, et al. EMBO J, 2000 Nov 1. PMID 11060042, Free PMC Article
    3. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_001337079.1
    NM_129981.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables initiator methionyl aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within N-terminal protein amino acid modification TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    methionine aminopeptidase 2A
    NP_566013.1
    • methionine aminopeptidase 2A (MAP2A); FUNCTIONS IN: metalloexopeptidase activity, aminopeptidase activity; INVOLVED IN: N-terminal protein amino acid modification; LOCATED IN: cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase M24, structural domain (InterPro:IPR000994), Peptidase M24A, methionine aminopeptidase, subfamily 2 (InterPro:IPR002468), Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site (InterPro:IPR018349), Peptidase M24, methionine aminopeptidase (InterPro:IPR001714); BEST Arabidopsis thaliana protein match is: methionine aminopeptidase 2B (TAIR:AT3G59990.4); Has 6503 Blast hits to 6494 proteins in 2220 species: Archae - 231; Bacteria - 4255; Metazoa - 425; Fungi - 336; Plants - 181; Viruses - 0; Other Eukaryotes - 1075 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18269211..18271941 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129981.5 → NP_566013.1  methionine aminopeptidase 2A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566013.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80587, Q9FV49
      UniProtKB/TrEMBL
      A0A5S9X7J9, A0A654F308, Q0WRL9
      Conserved Domains (2) summary
      cd01088
      Location:129 → 437
      MetAP2; Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
      PTZ00053
      Location:1 → 441
      PTZ00053; methionine aminopeptidase 2; Provisional

    2. NM_001337079.1 → NP_001323713.1  methionine aminopeptidase 2A [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VUM7, A0A178VW75, A0A1P8AY11, A0A384KR91
      Conserved Domains (1) summary
      PTZ00053
      Location:1 → 321
      PTZ00053; methionine aminopeptidase 2; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FV49.2

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