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    CKB4 casein kinase II beta subunit 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819076, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CKB4
    Official Full Name
    casein kinase II beta subunit 4
    Primary source
    TAIR:AT2G44680
    Locus tag
    AT2G44680
    See related
    Araport:AT2G44680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    casein kinase II beta subunit 4; casein kinase II beta subunit 4; F16B22.17
    Summary
    Encodes casein kinase II beta chain, a CK2 regulatory subunit. Nuclear-localized CKB4 protein exists in vivo as different isoforms, resulting from phosphorylation on serine residues. The phosphorylated isoforms are the preferred substrate for ubiquitination and degradation by the proteasome pathway. Involved in regulation of circadian clock.
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    Genomic context

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    See CKB4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_003071.7 (18426481..18428397, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene senescence-associated family protein (DUF581) Neighboring gene RAC-like 9 Neighboring gene Galactose oxidase/kelch repeat superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A role for CK2 β subunit 4 in the regulation of plant growth, cadmium accumulation and H(2)O(2) content under cadmium stress in Arabidopsis thaliana. Zhu J, et al. Plant Physiol Biochem, 2016 Dec. PMID 27750098
    2. Altered oscillator function affects clock resonance and is responsible for the reduced day-length sensitivity of CKB4 overexpressing plants. Portolés S, et al. Plant J, 2007 Sep. PMID 17662034
    3. The proteasome-dependent degradation of CKB4 is regulated by the Arabidopsis biological clock. Perales M, et al. Plant J, 2006 Jun. PMID 16709199
    4. The functional interplay between protein kinase CK2 and CCA1 transcriptional activity is essential for clock temperature compensation in Arabidopsis. Portolés S, et al. PLoS Genet, 2010 Nov 4. PMID 21079791, Free PMC Article
    5. Phosphorylation by CK2 enhances the rapid light-induced degradation of phytochrome interacting factor 1 in Arabidopsis. Bu Q, et al. J Biol Chem, 2011 Apr 8. PMID 21330376, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. elevated expression of CKB4 and increased protein kinase CK2 activity enhance the sensitivity of plants to Cd stress by affecting Cd and H2O2 accumulation, including the modulation of genes involved in Cd transport and H2O2 scavenging
      Title: A role for CK2 β subunit 4 in the regulation of plant growth, cadmium accumulation and H(2)O(2) content under cadmium stress in Arabidopsis thaliana.
    2. Data show that each of four beta subunits of CK2 strongly stimulated phosphorylation of phytochrome interacting factors by alpha1 or alpha2.
      Title: Phosphorylation by CK2 enhances the rapid light-induced degradation of phytochrome interacting factor 1 in Arabidopsis.
    3. This study establishes a new model demonstrating that two opposing and temperature-dependent activities (CCA1-CK2) are essential for clock temperature compensation in Arabidopsis.
      Title: The functional interplay between protein kinase CK2 and CCA1 transcriptional activity is essential for clock temperature compensation in Arabidopsis.
    4. Oscillator dysfunction is responsible for the period defect of CKB4-ox plants that leads to clock dissonance with the environment and reduced sensitivity to day length.
      Title: Altered oscillator function affects clock resonance and is responsible for the reduced day-length sensitivity of CKB4 overexpressing plants.
    5. CKB4, a CK2 regulatory subunit, is a component of the Arabidopsis circadian system. [CKB4]
      Title: The proteasome-dependent degradation of CKB4 is regulated by the Arabidopsis biological clock.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001337093.1
    NM_130032.3
    NM_180090.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within photoperiodism, flowering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    part_of protein kinase CK2 complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    casein kinase II beta subunit 4
    NP_181996.1
    • casein kinase II beta subunit 4 (CKB4); CONTAINS InterPro DOMAIN/s: Casein kinase II, regulatory subunit, alpha-helical (InterPro:IPR016149), Casein kinase II, regulatory subunit, beta-sheet (InterPro:IPR016150), Casein kinase II, regulatory subunit (InterPro:IPR000704); BEST Arabidopsis thaliana protein match is: casein kinase II beta chain 3 (TAIR:AT3G60250.1); Has 1093 Blast hits to 1091 proteins in 222 species: Archae - 0; Bacteria - 0; Metazoa - 429; Fungi - 285; Plants - 156; Viruses - 0; Other Eukaryotes - 223 (source: NCBI BLink).
    NP_850421.1
    • casein kinase II beta subunit 4 (CKB4); CONTAINS InterPro DOMAIN/s: Casein kinase II, regulatory subunit, alpha-helical (InterPro:IPR016149), Casein kinase II, regulatory subunit, beta-sheet (InterPro:IPR016150), Casein kinase II, regulatory subunit (InterPro:IPR000704); BEST Arabidopsis thaliana protein match is: casein kinase II beta chain 3 (TAIR:AT3G60250.2); Has 1093 Blast hits to 1091 proteins in 222 species: Archae - 0; Bacteria - 0; Metazoa - 429; Fungi - 285; Plants - 156; Viruses - 0; Other Eukaryotes - 223 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18426481..18428397 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130032.3 → NP_181996.1  casein kinase II beta subunit 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181996.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80507, Q941C4
      UniProtKB/TrEMBL
      A0A178VNS3, A0A5S9X707, A0A654F1Z2
      Conserved Domains (1) summary
      pfam01214
      Location:95 → 278
      CK_II_beta; Casein kinase II regulatory subunit

    2. NM_001337093.1 → NP_001323623.1  casein kinase II beta subunit 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VNS3, A0A1P8AXL7
      Conserved Domains (1) summary
      pfam01214
      Location:95 → 241
      CK_II_beta; Casein kinase II regulatory subunit

    3. NM_180090.2 → NP_850421.1  casein kinase II beta subunit 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850421.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VQG5, A0A7G2EKF0
      Conserved Domains (1) summary
      smart01085
      Location:95 → 277
      CK_II_beta; Casein kinase II regulatory subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O80507.1

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