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    KPHMT1 ketopantoate hydroxymethyltransferase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819219, updated on 18-Sep-2024

    Summary

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    Official Symbol
    KPHMT1
    Official Full Name
    ketopantoate hydroxymethyltransferase 1
    Primary source
    TAIR:AT2G46110
    Locus tag
    AT2G46110
    See related
    Araport:AT2G46110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ketopantoate hydroxymethyltransferase 1; PANB1; T3F17.24
    Summary
    Encodes a ketopentoate hydroxymethyltransferase that appears to localize to the mitochondria. This protein is expected to play a role in pantothenate (vitamin B5) biosynthesis.
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    Genomic context

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    See KPHMT1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_003071.7 (18954570..18956582, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene BPS1-like protein Neighboring gene Diacylglycerol kinase family protein Neighboring gene Nuclear transport factor 2 (NTF2) family protein Neighboring gene tRNA-Glu Neighboring gene WRKY DNA-binding protein 43

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Organisation of the pantothenate (vitamin B5) biosynthesis pathway in higher plants. Ottenhof HH, et al. Plant J, 2004 Jan. PMID 14675432
    2. Identification and molecular properties of SUMO-binding proteins in Arabidopsis. Park HC, et al. Mol Cells, 2011 Aug. PMID 21607647, Free PMC Article
    3. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article
    4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_130174.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 3-methyl-2-oxobutanoate hydroxymethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3-methyl-2-oxobutanoate hydroxymethyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in pantothenate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pantothenate biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ketopantoate hydroxymethyltransferase 1
    NP_182135.1
    • ketopantoate hydroxymethyltransferase 1 (KPHMT1); CONTAINS InterPro DOMAIN/s: Pyruvate/Phosphoenolpyruvate kinase, catalytic core (InterPro:IPR015813), Ketopantoate hydroxymethyltransferase (InterPro:IPR003700); BEST Arabidopsis thaliana protein match is: Phosphoenolpyruvate carboxylase family protein (TAIR:AT3G61530.2); Has 7565 Blast hits to 7565 proteins in 2036 species: Archae - 128; Bacteria - 4147; Metazoa - 4; Fungi - 140; Plants - 59; Viruses - 0; Other Eukaryotes - 3087 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18954570..18956582 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130174.5 → NP_182135.1  ketopantoate hydroxymethyltransferase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_182135.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82357
      UniProtKB/TrEMBL
      A0A5S9X7D9, A0A7G2EHT3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O82357.1

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