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    HBT CDC27 family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816519, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HBT
    Official Full Name
    CDC27 family protein
    Primary source
    TAIR:AT2G20000
    Locus tag
    AT2G20000
    See related
    Araport:AT2G20000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CDC27b; HOBBIT; T2G17.20; T2G17_20
    Summary
    Required for cell division and cell differentiation in meristems. Encodes a homolog of the CDC27 subunit of the anaphase-promoting complex (APC). Unlike other CDC27 homologs in Arabidopsis, its transcription is cell cycle regulated. Strong hbt mutants give rise to seedlings that lack an anatomically recognizable quiescent center and differentiated columella root cap cells, the cell types derived from the wild-type hypophysis. Furthermore, they have no mitotically active root meristem and lack a differentiated lateral root cap.
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    Genomic context

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    See HBT in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    16
    Sequence:
    Chromosome: 2; NC_003071.7 (8631959..8637300, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene CAP (Cysteine-rich secretory proteins, Antigen 5, and Pathogenesis-related 1 protein) superfamily protein Neighboring gene pathogenesis-related protein-1-like protein Neighboring gene Gls protein (DUF810) Neighboring gene RNA-binding CRS1 / YhbY (CRM) domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Non-cell-autonomous rescue of anaphase-promoting complex function revealed by mosaic analysis of HOBBIT, an Arabidopsis CDC27 homolog. Serralbo O, et al. Proc Natl Acad Sci U S A, 2006 Aug 29. PMID 16938844, Free PMC Article
    2. The Arabidopsis HOBBIT gene encodes a CDC27 homolog that links the plant cell cycle to progression of cell differentiation. Blilou I, et al. Genes Dev, 2002 Oct 1. PMID 12368267, Free PMC Article
    3. The HOBBIT gene is required for formation of the root meristem in the Arabidopsis embryo. Willemsen V, et al. Development, 1998 Feb. PMID 9425146
    4. Centromeric cohesion is protected twice at meiosis, by SHUGOSHINs at anaphase I and by PATRONUS at interkinesis. Cromer L, et al. Curr Biol, 2013 Nov 4. PMID 24206843
    5. Specialization of CDC27 function in the Arabidopsis thaliana anaphase-promoting complex (APC/C). Pérez-Pérez JM, et al. Plant J, 2008 Jan. PMID 17944809

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001335657.1
    NM_179663.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gamete generation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell division IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of unidimensional cell growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to auxin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root cap development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root meristem specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of anaphase-promoting complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of anaphase-promoting complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cell plate IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CDC27 family protein
    NP_849994.1
    • HOBBIT (HBT); FUNCTIONS IN: binding; INVOLVED IN: in 10 processes; LOCATED IN: anaphase-promoting complex, nucleus, cell plate, spindle; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide TPR-1 (InterPro:IPR001440), Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734); BEST Arabidopsis thaliana protein match is: Tetratricopeptide repeat (TPR)-like superfamily protein (TAIR:AT3G16320.1); Has 19127 Blast hits to 10740 proteins in 1344 species: Archae - 1126; Bacteria - 9300; Metazoa - 1888; Fungi - 782; Plants - 572; Viruses - 0; Other Eukaryotes - 5459 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      8631959..8637300 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179663.3 → NP_849994.1  CDC27 family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849994.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LGU6, Q8W4M8, Q9SL81
      UniProtKB/TrEMBL
      A0A178VWS3, A0A5S9WZG2, A0A654EUC3
      Conserved Domains (4) summary
      COG0457
      Location:452 → 715
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:518 → 546
      TPR; TPR repeat [structural motif]
      pfam08580
      Location:226 → 387
      KAR9; Yeast cortical protein KAR9
      pfam12895
      Location:15 → 88
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3

    2. NM_001335657.1 → NP_001323708.1  CDC27 family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VWS3, A0A1P8AXY8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LGU6.1

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