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    PDH-E1 ALPHA pyruvate dehydrogenase E1 alpha [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839429, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PDH-E1 ALPHA
    Official Full Name
    pyruvate dehydrogenase E1 alpha
    Primary source
    TAIR:AT1G01090
    Locus tag
    AT1G01090
    See related
    Araport:AT1G01090
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    pyruvate dehydrogenase E1 alpha; T25K16.8; T25K16_8
    Summary
    pyruvate dehydrogenase E1 alpha subunit
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    Genomic context

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    See PDH-E1 ALPHA in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (47234..49304, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene 60S acidic ribosomal protein family Neighboring gene IQ-domain 18

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and molecular analyses of the Arabidopsis thaliana plastid pyruvate dehydrogenase subunits. Johnston ML, et al. Biochim Biophys Acta, 1997 Oct 20. PMID 9393637
    2. Cosuppression of RBCS3B in Arabidopsis leads to severe photoinhibition caused by ROS accumulation. Zhan GM, et al. Plant Cell Rep, 2014 Jul. PMID 24682522
    3. Redox Conformation-Specific Protein-Protein Interactions of the 2-Cysteine Peroxiredoxin in Arabidopsis. Liebthal M, et al. Antioxidants (Basel), 2020 Jun 11. PMID 32545358, Free PMC Article
    4. Toward an interaction map of the two-component signaling pathway of Arabidopsis thaliana. Dortay H, et al. J Proteome Res, 2008 Sep. PMID 18642946
    5. Proteomic analysis of the 26S proteasome reveals its direct interaction with transit peptides of plastid protein precursors for their degradation. Sako K, et al. J Proteome Res, 2014 Jul 3. PMID 24846764

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_099991.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables pyruvate dehydrogenase (acetyl-transferring) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate dehydrogenase (acetyl-transferring) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process from pyruvate IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid HDA PubMed 
    located_in plastid ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pyruvate dehydrogenase E1 alpha
    NP_171617.1
    • pyruvate dehydrogenase E1 alpha (PDH-E1 ALPHA); FUNCTIONS IN: pyruvate dehydrogenase (acetyl-transferring) activity; INVOLVED IN: oxidation reduction, glycolysis, metabolic process; LOCATED IN: chloroplast, plastid, chloroplast envelope; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Dehydrogenase, E1 component (InterPro:IPR001017), Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y (InterPro:IPR017597); BEST Arabidopsis thaliana protein match is: pyruvate dehydrogenase complex E1 alpha subunit (TAIR:AT1G59900.1); Has 10065 Blast hits to 10059 proteins in 1888 species: Archae - 130; Bacteria - 6136; Metazoa - 517; Fungi - 241; Plants - 224; Viruses - 0; Other Eukaryotes - 2817 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      47234..49304 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_099991.4 → NP_171617.1  pyruvate dehydrogenase E1 alpha [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_171617.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O24457, Q9MAM6
      UniProtKB/TrEMBL
      A0A178W8A7, A0A5S9RZM7
      Conserved Domains (1) summary
      PLN02374
      Location:1 → 428
      PLN02374; pyruvate dehydrogenase (acetyl-transferring)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O24457.1

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