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    PTP1 protein tyrosine phosphatase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843516, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PTP1
    Official Full Name
    protein tyrosine phosphatase 1
    Primary source
    TAIR:AT1G71860
    Locus tag
    AT1G71860
    See related
    Araport:AT1G71860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATPTP1; F14O23.24; F14O23_24; protein tyrosine phosphatase 1; PROTEIN TYROSINE PHOSPHATASE 1
    Summary
    Encodes a protein with tyrosine phosphatase activity that is downregulated in response to cold and upregulated in response to salt stress.
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    Genomic context

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    See PTP1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    9
    Sequence:
    Chromosome: 1; NC_003070.9 (27026677..27029092)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene transducin family protein / WD-40 repeat family protein Neighboring gene Ubiquitin carboxyl-terminal hydrolase family protein Neighboring gene PyrD Neighboring gene ncRNA Neighboring gene EPIDERMAL PATTERNING FACTOR-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of a tyrosine-specific protein phosphatase encoded by a stress-responsive gene in Arabidopsis. Xu Q, et al. Plant Cell, 1998 May. PMID 9596642, Free PMC Article
    2. A low-temperature-responsive element involved in the regulation of the Arabidopsis thaliana At1g71850/At1g71860 divergent gene pair. Liu S, et al. Plant Cell Rep, 2016 Aug. PMID 27215439
    3. ATMPK4, an Arabidopsis homolog of mitogen-activated protein kinase, is activated in vitro by AtMEK1 through threonine phosphorylation. Huang Y, et al. Plant Physiol, 2000 Apr. PMID 10759527, Free PMC Article
    4. Quantitative phosphoproteomics of protein kinase SnRK1 regulated protein phosphorylation in Arabidopsis under submergence. Cho HY, et al. J Exp Bot, 2016 Apr. PMID 27029354, Free PMC Article
    5. MAP kinase phosphatase1 and protein tyrosine phosphatase1 are repressors of salicylic acid synthesis and SNC1-mediated responses in Arabidopsis. Bartels S, et al. Plant Cell, 2009 Sep. PMID 19789277, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the regulation of the Arabidopsis thaliana gene pair At1g71850/At1g71860 was investigated.
      Title: A low-temperature-responsive element involved in the regulation of the Arabidopsis thaliana At1g71850/At1g71860 divergent gene pair.
    2. MKP1 and PTP1 act redundantly to suppress salicylic acid and camalexin biosynthesis, and regulate growth homeostasis and PR gene expression in an MPK3- and MPK6-dependent manner.
      Title: MAP kinase phosphatase1 and protein tyrosine phosphatase1 are repressors of salicylic acid synthesis and SNC1-mediated responses in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036189.1
    NM_105844.4
    NM_202398.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables MAP kinase tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of defense response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in intracellular anatomical structure TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    protein tyrosine phosphatase 1
    NP_001031266.1
    • protein tyrosine phosphatase 1 (PTP1); FUNCTIONS IN: protein tyrosine phosphatase activity; INVOLVED IN: intracellular protein kinase cascade; LOCATED IN: nucleus, plasma membrane, cytoplasm; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein-tyrosine phosphatase, active site (InterPro:IPR016130), Dual-specific/protein-tyrosine phosphatase, conserved region (InterPro:IPR000387), Protein-tyrosine phosphatase, receptor/non-receptor type (InterPro:IPR000242); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_177331.1
    • protein tyrosine phosphatase 1 (PTP1); FUNCTIONS IN: protein tyrosine phosphatase activity; INVOLVED IN: intracellular protein kinase cascade; LOCATED IN: nucleus, plasma membrane, cytoplasm; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein-tyrosine phosphatase, active site (InterPro:IPR016130), Dual-specific/protein-tyrosine phosphatase, conserved region (InterPro:IPR000387), Protein-tyrosine phosphatase, receptor/non-receptor type (InterPro:IPR000242); Has 6497 Blast hits to 5202 proteins in 282 species: Archae - 2; Bacteria - 98; Metazoa - 5552; Fungi - 319; Plants - 71; Viruses - 173; Other Eukaryotes - 282 (source: NCBI BLink).
    NP_974127.1
    • protein tyrosine phosphatase 1 (PTP1); FUNCTIONS IN: protein tyrosine phosphatase activity; INVOLVED IN: intracellular protein kinase cascade; LOCATED IN: nucleus, plasma membrane, cytoplasm; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein-tyrosine phosphatase, receptor/non-receptor type (InterPro:IPR000242); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      27026677..27029092
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105844.4 → NP_177331.1  protein tyrosine phosphatase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177331.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65190, O82656
      UniProtKB/TrEMBL
      A0A178WDU2, A0A5S9WRJ2
      Conserved Domains (1) summary
      cd17658
      Location:117 → 321
      PTPc_plant_PTP1; protein tyrosine phosphatase 1 from Arabidopsis thaliana and similar plant PTPs

    2. NM_001036189.1 → NP_001031266.1  protein tyrosine phosphatase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031266.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65190, O82656
      UniProtKB/TrEMBL
      A0A178WDU2, A0A5S9WRJ2
      Conserved Domains (1) summary
      cd17658
      Location:117 → 321
      PTPc_plant_PTP1; protein tyrosine phosphatase 1 from Arabidopsis thaliana and similar plant PTPs

    3. NM_202398.1 → NP_974127.1  protein tyrosine phosphatase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974127.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4IA41
      Conserved Domains (2) summary
      cd00047
      Location:89 → 265
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00102
      Location:87 → 267
      Y_phosphatase; Protein-tyrosine phosphatase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O82656.1

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