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    CYP59 cyclophilin 59 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841810, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CYP59
    Official Full Name
    cyclophilin 59
    Primary source
    TAIR:AT1G53720
    Locus tag
    AT1G53720
    See related
    Araport:AT1G53720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCYP59; cyclophilin 59; CYCLOPHILIN 59; F22G10.24; F22G10_24
    Summary
    Encodes a cyclophilin, member of a family modular proteins consisting of a peptidyl-prolyl cis#Aei trans isomerase (PPIase) domain, followed by an RNA recognition motif (RRM), and a C-terminal domain enriched in charged amino acids. Interacts with with SCL33/SR33 and with a majority of Arabidopsis SR proteins and the largest subunit of RNA polymerase II. Localizes to the nucleus, but it does not significantly colocalize with SR proteins in nuclear speckles.
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    Genomic context

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    See CYP59 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    12
    Sequence:
    Chromosome: 1; NC_003070.9 (20056526..20059803)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Calcineurin-like metallo-phosphoesterase superfamily protein Neighboring gene ROTUNDIFOLIA like 9 Neighboring gene STRUBBELIG-receptor family 6 Neighboring gene regulatory particle triple-A 1A Neighboring gene K+-H+ exchange-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of RNA targets for the nuclear multidomain cyclophilin atCyp59 and their effect on PPIase activity. Bannikova O, et al. Nucleic Acids Res, 2013 Feb 1. PMID 23248006, Free PMC Article
    2. AtCyp59 is a multidomain cyclophilin from Arabidopsis thaliana that interacts with SR proteins and the C-terminal domain of the RNA polymerase II. Gullerova M, et al. RNA, 2006 Apr. PMID 16497658, Free PMC Article
    3. Identification of BZR1-interacting proteins as potential components of the brassinosteroid signaling pathway in Arabidopsis through tandem affinity purification. Wang C, et al. Mol Cell Proteomics, 2013 Dec. PMID 24019147, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The identification of an RNA-binding motif,(G[U/C]N[G/A]CC[A/G], for AtCyp59.
      Title: Identification of RNA targets for the nuclear multidomain cyclophilin atCyp59 and their effect on PPIase activity.
    2. AtCyp59 interacts with the C-terminal domain (CTD) of the largest subunit of RNA polymerase II. The data suggests a possible function of AtCyp59 in activities connecting transcription and pre-mRNA processing [AtCyp59]
      Title: AtCyp59 is a multidomain cyclophilin from Arabidopsis thaliana that interacts with SR proteins and the C-terminal domain of the RNA polymerase II.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001333607.1
    NM_104250.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cyclophilin 59
    NP_175776.2
    • cyclophilin 59 (CYP59); FUNCTIONS IN: peptidyl-prolyl cis-trans isomerase activity, RNA binding, nucleic acid binding; INVOLVED IN: protein folding; LOCATED IN: nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cyclophilin-like (InterPro:IPR015891), Peptidyl-prolyl cis-trans isomerase, cyclophilin-type (InterPro:IPR002130), RNA recognition motif, RNP-1 (InterPro:IPR000504), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677), Zinc finger, CCHC-type (InterPro:IPR001878); BEST Arabidopsis thaliana protein match is: peptidyl-prolyl cis-trans isomerases;hydrolases;nucleoside-triphosphatases;ATP binding;nucleotide binding;ATPases (TAIR:AT1G53780.2); Has 61647 Blast hits to 39757 proteins in 2942 species: Archae - 163; Bacteria - 9741; Metazoa - 25019; Fungi - 7217; Plants - 5688; Viruses - 226; Other Eukaryotes - 13593 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      20056526..20059803
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104250.5 → NP_175776.2  cyclophilin 59 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175776.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6Q151, Q93YQ8, Q9C8M7
      UniProtKB/TrEMBL
      A0A654EJN3
      Conserved Domains (3) summary
      COG0724
      Location:145 → 340
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd01921
      Location:4 → 169
      cyclophilin_RRM; cyclophilin_RRM: cyclophilin-type peptidylprolyl cis- trans isomerase domain occuring with a C-terminal RNA recognition motif domain (RRM). This subfamily of the cyclophilin domain family contains a number of eukaryotic cyclophilins having the RRM domain ...
      cd12235
      Location:240 → 322
      RRM_PPIL4; RNA recognition motif in peptidyl-prolyl cis-trans isomerase-like 4 (PPIase) and similar proteins

    2. NM_001333607.1 → NP_001321367.1  cyclophilin 59 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AQN8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6Q151.1

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