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    CAX2 cation exchanger 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820532, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CAX2
    Official Full Name
    cation exchanger 2
    Primary source
    TAIR:AT3G13320
    Locus tag
    AT3G13320
    See related
    Araport:AT3G13320
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    atcax2; cation exchanger 2; MDC11.19
    Summary
    low affinity calcium antiporter CAX2
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    Genomic context

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    See CAX2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    13
    Sequence:
    Chromosome: 3; NC_003074.8 (4314505..4318487)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene Chaperone DnaJ-domain superfamily protein Neighboring gene proteasome activating protein 200 Neighboring gene tRNA-Asp

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The vacuolar Ca(2+) transporter CATION EXCHANGER 2 regulates cytosolic calcium homeostasis, hypoxic signaling, and response to flooding in Arabidopsis thaliana. Bakshi A, et al. New Phytol, 2023 Dec. PMID 37743731
    2. Evidence of differential pH regulation of the Arabidopsis vacuolar Ca2+/H+ antiporters CAX1 and CAX2. Pittman JK, et al. FEBS Lett, 2005 May 9. PMID 15862304
    3. Phylogenetic relationships within cation transporter families of Arabidopsis. Mäser P, et al. Plant Physiol, 2001 Aug. PMID 11500563, Free PMC Article
    4. CAX1, an H+/Ca2+ antiporter from Arabidopsis. Hirschi KD, et al. Proc Natl Acad Sci U S A, 1996 Aug 6. PMID 8710949, Free PMC Article
    5. Differential binding of calmodulin-related proteins to their targets revealed through high-density Arabidopsis protein microarrays. Popescu SC, et al. Proc Natl Acad Sci U S A, 2007 Mar 13. PMID 17360592, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The vacuolar Ca[2+] transporter CATION EXCHANGER 2 regulates cytosolic calcium homeostasis, hypoxic signaling, and response to flooding in Arabidopsis thaliana.
      Title: The vacuolar Ca(2+) transporter CATION EXCHANGER 2 regulates cytosolic calcium homeostasis, hypoxic signaling, and response to flooding in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_112177.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium:monoatomic cation antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables calcium:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium:proton antiporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cadmium ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within calcium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within calcium ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within manganese ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within metal ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within metal ion transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plant-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cation exchanger 2
    NP_566452.1
    • cation exchanger 2 (CAX2); CONTAINS InterPro DOMAIN/s: Sodium/calcium exchanger membrane region (InterPro:IPR004837), Calcium/proton exchanger superfamily (InterPro:IPR004798), Calcium/proton exchanger (InterPro:IPR004713); BEST Arabidopsis thaliana protein match is: cation exchanger 5 (TAIR:AT1G55730.2); Has 3194 Blast hits to 3028 proteins in 968 species: Archae - 39; Bacteria - 1824; Metazoa - 15; Fungi - 731; Plants - 247; Viruses - 0; Other Eukaryotes - 338 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      4314505..4318487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112177.3 → NP_566452.1  cation exchanger 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566452.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q39254, Q944Q1, Q9LTT6
      UniProtKB/TrEMBL
      A0A178VHU2, A0A7G2EM62
      Conserved Domains (1) summary
      TIGR00846
      Location:71 → 431
      caca2; calcium/proton exchanger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q39254.2

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