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    AHP2 histidine-containing phosphotransmitter 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 822593, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AHP2
    Official Full Name
    histidine-containing phosphotransmitter 2
    Primary source
    TAIR:AT3G29350
    Locus tag
    AT3G29350
    See related
    Araport:AT3G29350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    histidine-containing phosphotransmitter 2
    Summary
    Encodes AHP2, one of the six Arabidopsis thaliana histidine phosphotransfer proteins (AHPs). AHPs function in His-to-Asp phosphorelay signal transduction and as redundant positive regulators of cytokinin signaling. Members of the AHP gene family include: AT3G21510 (AHP1), AT3G29350 (AHP2), AT5G39340 (AHP3), AT3G16360 (AHP4), AT1G03430 (AHP5) and AT1G80100 (AHP6).
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    Genomic context

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    See AHP2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    6
    Sequence:
    Chromosome: 3; NC_003074.8 (11264126..11265562, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Glycosyl transferase, family 35 Neighboring gene zinc finger RNA-binding-like protein Neighboring gene zinc finger (C2H2 type) family protein Neighboring gene UDP-glucose 6-dehydrogenase family protein Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ahp2 (Hop2) function in Arabidopsis thaliana (Ler) is required for stabilization of close alignment and synaptonemal complex formation except for the two short arms that contain nucleolus organizer regions. Stronghill P, et al. Chromosoma, 2010 Aug. PMID 20358378
    2. Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of AHP2, a signal transmitter protein from Arabidopsis thaliana. Degtjarik O, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2013 Feb 1. PMID 23385758, Free PMC Article
    3. An Arabidopsis histidine-containing phosphotransfer (HPt) factor implicated in phosphorelay signal transduction: overexpression of AHP2 in plants results in hypersensitiveness to cytokinin. Suzuki T, et al. Plant Cell Physiol, 2002 Jan. PMID 11828030
    4. The Arabidopsis thaliana MND1 homologue plays a key role in meiotic homologous pairing, synapsis and recombination. Kerzendorfer C, et al. J Cell Sci, 2006 Jun 15. PMID 16763194
    5. The response regulator ARR2: a pollen-specific transcription factor involved in the expression of nuclear genes for components of mitochondrial complex I in Arabidopsis. Lohrmann J, et al. Mol Genet Genomics, 2001 Mar. PMID 11370868

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AHP2 is present in the nucleus and the cytoplasm, and is involved in light-induced stomata opening.The AHP2 gene is expressed in guard cells.
      Title: Involvement of two-component signalling systems in the regulation of stomatal aperture by light in Arabidopsis thaliana.
    2. The three-dimensional structure of AHP2 was determined.
      Title: Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of AHP2, a signal transmitter protein from Arabidopsis thaliana.
    3. ARR1 mediates cold signal via AHP2 (Arabidopsis histidine kinase 2), AHP3, or AHP5.
      Title: Arabidopsis response Regulator1 and Arabidopsis histidine phosphotransfer Protein2 (AHP2), AHP3, and AHP5 function in cold signaling.
    4. Arabidopsis AHP2, AHP3, and AHP5 histidine phosphotransfer proteins function as redundant negative regulators of drought stress response.
      Title: Arabidopsis AHP2, AHP3, and AHP5 histidine phosphotransfer proteins function as redundant negative regulators of drought stress response.
    5. findings suggest that the presence of Ahp2 protein is necessary for alignment stabilization and synapsis of most chromosome regions but is not required for initial close juxtapositions of homologous chromosomes
      Title: Ahp2 (Hop2) function in Arabidopsis thaliana (Ler) is required for stabilization of close alignment and synaptonemal complex formation except for the two short arms that contain nucleolus organizer regions.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_113860.4
    NM_180318.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables histidine phosphotransfer kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histidine phosphotransfer kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein histidine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within antipodal cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cytokinin-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cytokinin-activated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo sac egg cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorelay signal transduction system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cytokinin-activated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histidine-containing phosphotransmitter 2
    NP_189581.1
    • histidine-containing phosphotransmitter 2 (AHP2); CONTAINS InterPro DOMAIN/s: Signal transduction histidine kinase, phosphotransfer (Hpt) domain (InterPro:IPR008207); BEST Arabidopsis thaliana protein match is: histidine-containing phosphotransmitter 3 (TAIR:AT5G39340.1); Has 369 Blast hits to 368 proteins in 74 species: Archae - 2; Bacteria - 69; Metazoa - 0; Fungi - 28; Plants - 267; Viruses - 0; Other Eukaryotes - 3 (source: NCBI BLink).
    NP_850649.1
    • histidine-containing phosphotransmitter 2 (AHP2); CONTAINS InterPro DOMAIN/s: Signal transduction histidine kinase, phosphotransfer (Hpt) domain (InterPro:IPR008207); BEST Arabidopsis thaliana protein match is: histidine-containing phosphotransmitter 3 (TAIR:AT5G39340.1); Has 298 Blast hits to 297 proteins in 39 species: Archae - 2; Bacteria - 10; Metazoa - 0; Fungi - 21; Plants - 263; Viruses - 0; Other Eukaryotes - 2 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      11264126..11265562 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113860.4 → NP_189581.1  histidine-containing phosphotransmitter 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_189581.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3EAX3, Q9ZNV8
      UniProtKB/TrEMBL
      A0A178VEN2, A0A5S9XGR9, A0A654FDQ7
      Conserved Domains (1) summary
      pfam01627
      Location:46 → 130
      Hpt; Hpt domain

    2. NM_180318.2 → NP_850649.1  histidine-containing phosphotransmitter 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850649.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9ZNV8
      Conserved Domains (1) summary
      cd00088
      Location:44 → 111
      HPT; Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZNV8.1

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